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Office of Protocol Review and Monitoring

The Office of Protocol Review and Monitoring (OPRM) is an administrative arm of Yale Cancer Center dedicated to the management and coordination of the Center’s Protocol Review and Monitoring (PRMS) and Data and Safety Monitoring (DSM) functions in order to support, facilitate, and assure the highest quality clinical research at Yale. 

Three major components provide for clinical research review and oversight: the Protocol Review Committee (PRC), the Protocol Lifecycle Subcommitte (PLCS) of the PRC, and the Data and Safety Monitoring Committee (DSMC), and OPRM manages and tracks all committee and related activities.  These committees are responsible for reviewing and monitoring all Cancer clinical protocol science, designs and analyses, use of Center resources, continued progress, and data and safety compliance.

OPRM also provides an ongoing training and education program for clinical research staff to assist them in managing clinical trials and complying with regulatory requirements.

Protocol Review Committee (PRC)

Chair: Joesph Paul Eder, MD 
Contact: LaToya Howard
Phone – (203) 737-3661 or latoya.howard@yale.edu

Protocol Life Cycle Subcommittee (PLCS) of the PRC

Chair: Howard Hochster, MD 
Contact: LaToya Howard
Phone – (203) 737-3661 or latoya.howard@yale.edu

Data and Safety Monitoring Committee (DSMC)

Chair: Michal Rose, MD
Contact: LaToya Howard
Phone – (203) 737-3661 or latoya.howard@yale.edu

The OPRM operates under guidelines determined by the National Cancer Institute’s requirements for funding within the Cancer Center Support Grant (CCSG).