| Grand Rounds Resume September 7th
I hope you will join me as we begin another year of grand rounds on Tuesday, September 7th at noon in the auditorium at 55 Park Street. We will continue our weekly schedule and plan to have two speakers present during each rounds. The schedule begins on Tuesday with presentations by Marcus Bosenberg and Peter Peduzzi. We will hear from Howard Hochster and Ellen Matloff the following week on September 14th. A full schedule can be found on the Yale Cancer Center calendar.
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Chief of Medical Oncology
I am pleased to announce that we have an active search committee in place for the Chief of Medical Oncology position at Yale Cancer Center. As you know, Ed Chu left Yale Cancer Center on September 1st to assume an exciting new position at the University of Pittsburgh. I wish him the best as he continues his career as Deputy Director and Chief of Medical Oncology at the University of Pittsburgh Cancer Center. During the transition, I will serve as Interim Chief of Medical Oncology. Please contact me with any questions or concerns that you may have during this transition time.
Cancer Student Interest Group
Yale School of Medicine students recently formed an interest group to learn more about careers in cancer research and care. To support their efforts, Yale Cancer Center faculty members will be asked to meet with the students during their regular meetings. Please support their efforts and share your expertise and experiences with them.
Lung Cancer Patients Receiving Palliative Care had Improved Quality of Life, Extended Survival
The recent study in the August 19 issue of the
New England Journal of Medicine highlights the benefits and need for palliative care programs for cancer patients. At Yale Cancer Center and Smilow Cancer Hospital at Yale-New Haven, we are planning a dramatic enhancement of our palliative care service under the direction of Dr. Lawrence Solomon. Based on research done at Massachusetts General Hospital Cancer Center, the NEJM article notes that integrating palliative care early in the treatment of patients with advanced lung cancer not only improved their mood and quality of life, it also extended their lives.
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To refer a patient to the Smilow Cancer Hospital Palliative Care Service, please call (203) 737-4353.
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Making Team Science Work: Advice From a Team
The Yale SPORE in Skin Cancer
A long-term commitment and an ego-free workplace allows the Yale Melanoma Research Group to excel.
A feature article from the Clinical and Translational Science Network from the journal
Science .
Read the Full Article >>
Cellular Toolkit for DNA Repair Found by Yale Researchers
Yale researchers have identified key mechanisms used to repair breaks in DNA strands, a fundamental question in biology with implications for cancer research. Chromosomes are constantly under assault from environmental threats such as radiation and, as a consequence, suffer breaks in strands of DNA. If left unrepaired, these DNA breaks can lead to the development of cancer. The process of break repair is so complex it has baffled scientists for decades.
In a paper published in the September 2 issue of the journal Nature, the Yale team led by Patrick Sung, Chair of the Department of Molecular Biophysics and Biochemistry and member of the Yale Cancer Center Radiobiology and Radiotherapy Research Program, and collaborators at the Baylor School of Medicine identified 10 proteins crucial to the process and outlined how those proteins interact to initiate the repair of the breaks.
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The Hartwell Foundation 2010 Individual Biomedical Research Award
For early-stage, innovative, and cutting-edge biomedical research that has not yet qualified for significant funding from outside sources and that should benefit children, particularly in the U.S. - Investigators whose prior research may not have focused on benefiting children, but who now propose a relevant project benefiting children, are also encouraged to apply.
- For individuals with a full-time appointment who hold U.S. citizenship or permanent resident status.
- Faculty at any level may apply.
- $100,000 per year for 3 years. ($300,000)
Application Deadline: September 20, 2010
Pancreatic Cancer Action Network Innovative Grant The grant supports creative and cutting edge ideas and approaches, including those successful in other areas of cancer that have justifiable promise for pancreatic cancer. The grants program is designed to help incubate innovative research projects, grow the number of researchers directly working on pancreatic cancer, nurture collaborations across disciplines and institutions, and expedite scientific progress for patient benefit. In addition to receiving financial support for their research, grantees participate in a mentorship program that connects them with leading scientists in the field.
Application Deadline: October 4, 2010
Women's Health Research at Yale (WHRY) is now accepting Letters of Intent
for Pilot Project Research Funding
Projects strongly encouraged are those: - focusing on translational research and practical health benefits
- representing a new direction in women's health research or in understanding sex/gender differences in health or disease
- using an interdisciplinary perspective
WHRY supports: - clinical and behavioral, translational laboratory, health services, or prevention research
- projects oriented toward translation of empirical findings into practice
Application Deadline: October 13, 2010
Hope Funds for Cancer Research The Hope Funds for Cancer Research is pleased to announce a request for research proposals for postdoctoral fellows working in oncology. These 2-3 year fellowships will be awarded to postdoctoral scientists commencing in 2011.
Fellowships will be awarded to scientists who propose to work on
highly innovative research projects that challenge the traditional paradigms of understanding the causes, mechanisms, progression, disease markers or risk factors of the most difficult-to-treat cancers, including pancreatic, lung, liver, sarcomas, esophageal, brain, gastric and ovarian cancers.
Application Deadline: September 17, 2010 at 5:00 PM
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Recent Publications
IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response.
Rao P, Hayden MS, Long M, Scott ML, West AP, Zhang D, Oeckinghaus A, Lynch C, Hoffmann A, Baltimore D, Ghosh S.
Nature. 2010 Aug 26;466(7310):1115-9.
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Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy.
Berger C, Hoffmann K, Vasquez JG, Mane S, Lewis J, Filler R, Lin A, Zhao H, Durazzo T, Baird A, Lin W, Foss F, Christensen I, Girardi M, Tigelaar R, Edelson R.
Blood. 2010 Aug 18.
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The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity.
Lam W, Bussom S, Guan F, Jiang Z, Zhang W, Gullen EA, Liu SH, Cheng YC.
Sci Transl Med. 2010 Aug 18;2(45):45ra59.
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A Nomogram to Assess Small-Intestinal Neuroendocrine Tumor ('Carcinoid') Survival.
Modlin IM, Gustafsson BI, Pavel M, Svejda B, Lawrence B, Kidd M.
Neuroendocrinology. 2010 Aug 23.
Read More >>
Paclitaxel accelerates spontaneous calcium oscillations in cardiomyocytes by interacting with NCS-1 and the InsP(3)R.
Zhang K, Heidrich FM, Degray B, Boehmerle W, Ehrlich BE.
J Mol Cell Cardiol. 2010 Aug 26.
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Effect of mitomycin C on concentrations of vascular endothelial growth factor and its receptors in bladder cancer cells and in bladders of rats intravesically instilled with mitomycin C.
Verma A, Degrado J, Hittelman AB, Wheeler MA, Kaimakliotis HZ, Weiss RM.
BJU Int. 2010 Aug 24.
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As we bring demethylating drugs to the clinic, we better know the DICE being cast.
Lizardi PM.
Oncogene. 2010 Aug 23.
Read More >>
Salvage external beam radiotherapy for prostate cancer after radical prostatectomy: current status and controversy.
Raldow A, Hamstra DA, Kim S, Yu JB.
Oncology (Williston Park). 2010 Jul;24(8):692-700, 702.
Read More >>
A Remote Arene-Binding Site on Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules.
Zhang AX, Murelli RP, Barinka C, Michel J, Cocleaza A, Jorgensen WL, Lubkowski J, Spiegel DA.
J Am Chem Soc. 2010 Aug 20.
Read More >>
hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor for immunotherapy of uterine serous papillary carcinoma.
Cocco E, Hu Z, Richter CE, Bellone S, Casagrande F, Bellone M, Todeschini P, Krikun G, Silasi DA, Azodi M, Schwartz PE, Rutherford TJ, Buza N, Pecorelli S, Lockwood CJ, Santin AD.
Br J Cancer. 2010 Aug 10.
Read More >>
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| Inside Yale Cancer Center
Subscribe to Yale Cancer Center Answers on iTunes
Yale Cancer Center's weekly radio program on CT Public Radio is ranked number 2 in the world for cancer programs on iTunes. Subscribe to the show.
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Cancer Bytes
Hosted by Ellen Matloff, listen to the latest interview with Laura.
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Yale Cancer Center Grand Rounds
Video presentations from Yale Cancer Center members are now available online.
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DirectConnect Archives
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Events
September 3; 1:00 PM
Neuro-Oncology Tumor Board
WWW 201
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September 3; 1:00 PM
Hematology/Leukemia Tumor Board
WWW 201
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September 5; 6:00 PM
Yale Cancer Center Answers
WNPR 90.5
Oncology Social Work
Mary Crooks, LCSW
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September 7; 8:30 AM
Lymphoma/Stem Cell Meeting
WWW 201
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September 7; 12:00 PM
Grand Rounds
55 Park Street Auditorium
Modeling Tumor Heterogeneity in Malignant Melanoma
Marcus Bosenberg, MD, PhD
Yale Center for Analytical Sciences: Bringing Biostatistics Under One Umbrella
Peter Peduzzi, PhD
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September 7; 4:00 PM
Gastrointestinal Tumor Board
WWW 201
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September 7; 4:00 PM
Gynecologic Oncology Conference
621 EP 2nd Floor
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September 8; 12:00 PM
Research and Design Clinics: Yale Center for Analytical Sciences
LEPH 108
September 8; 4:00 PM
Epigenetics Interest Group Meeting
BML 137
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September 8; 4:30 PM
Family Caregiver Support Group
Smilow Cancer Hospital
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September 8; 4:30 PM
Breast Tumor Board
WWW 201
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September 9; 4:00 PM
Pediatric Tumor Board
646 EP 2nd Floor
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September 10; 1:00 PM
Molecular Virology Research Program Conference
SHM I-116
Transmembrane Protein Inhibitors of CCR5 HIV Coreceptor Activity
Elizabeth Harker, PhD
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September 10; 1:00 PM
Neuro-Oncology Tumor Board
WWW 201
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September 12; 6:00 PM
Yale Cancer Center Answers
WNPR 90.5
Nutrition and Cancer
Maura Harrigan, RD
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September 14; 12:00 PM
Yale Cancer Center Grand Rounds
55 Park Street
Oxaliplatin Neurotoxicity and Biologics: Maximizing Clinical Benefit
Howard Hochster, MD
Errors in Delivery of Cancer Genetics Services: Implications for Practice
Ellen Matloff, MS
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September 16; 12:00 PM
Schwartz Center Rounds
55 Park Street
A Disconnect between Family and Medical Team
Learn More >>
October 15 - 17, 2010
Oncology Congress
San Francisco, CA
Yale Cancer Center Member Rate - $100
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Submissions
Please submit your recent publication and grant announcements to:
Renee Gaudette
Director, Public Affairs and Marketing
renee.gaudette@yale.edu
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