| Announcements
Transplant Team Achieves Top Results The new national statistics on bone marrow transplants were recently released on the National Marrow Donor Program website and the team from Smilow Cancer Hospital/Yale Cancer Center has once again achieved remarkable results. Of the 157 transplant centers included in the center-specific statistics; Yale was one of 11 centers that had 1-yr survival statistics that were better than 2 standard deviations above predicted.
The predicted one-year survival for our patients was 63% and the actual survival was 73%.
Congratulations to Dennis Cooper and the entire Transplant team!
Bonnie Gould Rothberg, MD, PhD, MPH Joins Medical Oncology Bonnie Gould Rothberg, MD, PhD, MPH will join the Yale Cancer Center faculty on July 15 as an Assistant Professor of Medical Oncology. She will focus her efforts on our translational research goals, specifically in cancer epidemiology and tumor banking, under the mentorship of Dr. Roy Herbst, Chief of Medical Oncology.
Dr. Gould Rothberg is currently an associate research scientist in the laboratory of Dr. David Rimm in the department of pathology and will continue to work with Dr. Rimm on our DNA sequencing efforts.
She is the principal investigator on an NIH funded grant to study prognostic markers in metastatic melanoma.
Prior to coming to Yale, Dr. Gould Rothberg served as the Director of Clinical Development for the Rothberg Institute for Childhood Diseases and Group Leader for Medical Affairs at CuraGen Corporation .
Dr. Gould Rothberg received her doctorate degree in Epidemiology from the Yale Graduate School of Arts and Sciences and both her medical degree and master's degree in public health from Yale School of Medicine. |
Research in the News False Negative Tests in Breast Cancer May Lead to Wrong Drug Choice A team of Yale Cancer Center researchers has confirmed that between 10-20% of breast cancers classified as Estrogen Receptor (ER) negative are really positive. Understanding when and why breast cancers may be misclassified has important implications for treatment and outcomes for women diagnosed with breast cancer. Its findings are published online in the June 28 Journal of Clinical Oncology. A woman diagnosed with breast cancer can be tested by immunohistochemistry (IHC), a process that detects the presence of specific proteins in cancer tissue. Those who test positive for ER are prescribed an endocrine therapy, like Tamoxifen, Letrazol or a similar drug. The 10-20% of cancer patients who are incorrectly classified as ER negative may be treated with less effective therapies. Learn More >>
Yale Researchers Design a Better Way to Discover Drug Candidates
Yale researchers have devised a novel way to trick cells into getting rid of problematic proteins, a method that could help pharmaceutical companies quickly identify promising targets for new drugs.
"Our new approach offers great potential in overcoming a key stumbling block in drug development today: the validation of drug target proteins in living organisms," said Craig Crews, the Lewis B. Cullman Professor of Molecular, Cellular and Developmental Biology, professor of chemistry and pharmacology, member of Yale Cancer Center, and senior author of the study.
Learn More >>
|
Notables
Julie Boyer has accepted a new position at Yale Cancer Center as Associate Director for Translational Research Administration working with Dr. Roy Herbst. Prior to joining the cancer center, Julie was an assistant director of development for science and engineering at Yale.
In her new role, she will facilitate the transition of promising basic research discoveries into clinical studies at Yale Cancer Center.
Dr. Michelle Sowden recently completed the breast surgery fellowship at Yale and has received an ASCO Breast Merit Award for her work submitted to the ASCO Breast Symposium on September 8-10. Sowden M, Sanft TB, Chagpar AB. "Who provides ongoing care to breast cancer survivors and does it make a difference?"Ruth McCorkle was awarded funding to advance research on cancers in women through the NCI Women's Health Activities Committee to support her project, Testing the Feasibility of a Nurse Patient Navigation Intervention in Lung Cancer.
Dr. Lieping Chen presented the closing plenary lecture at the XXXVI Congress of the Spanish Society of Immunology in Pamplona, Spain on June 11th. His presentation reviewed his research showing that experimental treatments aimed at manipulating the molecules that promote the immune response against cancer can eliminate multiple mouse tumor models.
|
Funding and Award Opportunities
Lymphoma Research Foundation Two-Year Postdoctoral Fellowships The LRF Fellowship provides salary support in the amount of $45,000 for the first year and $50,000 for the second year. Additionally, $5,000 per year is allotted for the research project. This makes for a total of $105,000 over two years. This Grant does not provide for institutional overhead. Application Deadline: August 26, 2011 Learn More >> The Komen Investigator-Initiated Research (IIR) Grant Investigator-Initiated Research (IIR) Grants seek to stimulate exploration of new ideas and novel approaches in breast cancer research and clinical practice that have significant potential to lead to reductions in breast cancer incidence and/or mortality within the next decade. Application Deadline: August 10, 2011 Learn More >> (PDF) The Komen Career Catalyst Grant Career Catalyst Research (CCR) Grants are intended to foster increased research independence of promising breast cancer researchers who are in the early stages of their faculty careers. These Grants provide support for research projects that have significant potential to advance our understanding of breast cancer and lead to reductions in breast cancer incidence and/or mortality within the next decade. Application Deadline: August 30, 2011 Learn More >> (PDF) Department of Defense Visionary Postdoctoral Fellowship Award *Research must be in one or more of the FY11 PRCRP Topic Areas
*Supports postdoctoral fellows training in the laboratory of early career investigators (mentor) with expertise in one or more of the FY11 PRCRP Topic Areas
*Supports postdoctoral training to include a budget option for research supplies
*Applications must not address breast, prostate, lung (excluding Mesothelioma), and ovarian cancer research
*Preliminary data not required
*Clinical trials will not be supported Application Deadline: August 10, 2011
Learn More >> Prostate Cancer Foundation Young Investigator Awards The Prostate Cancer Foundation champions human capital investment to fast-forward solutions to prostate cancer. We are pleased to announce a new round of funding for Prostate Cancer Researchers. Consistent with our goal to end death and suffering from prostate cancer, we would like to focus efforts on developing another gifted cohort of human capital in prostate cancer research. Highly innovative basic science programs will be carefully considered, but priority will be given to "bench to bedside" translational research proposals with the potential to deliver near term benefit to patients. Application Deadline: August 1, 2011
Learn More >> Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research OBJECTIVES: The sponsor provides an award to recognize outstanding achievements in clinical cancer research.
ELIGIBILITY: Candidacy is open to all cancer researchers who are affiliated with any institution involved in cancer research, cancer medicine or cancer-related biomedical science anywhere in the world. Such institutions include those in academia, industry or government. The award will be presented to an individual investigator. Institutions or organizations are not eligible for the award.
FUNDING: The winner of the 17th Annual AACR Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research will give a 50-minute lecture during the AACR 103rd Annual Meeting 2012, receive an honorarium of $10,000, and be given support for the winner and a guest to attend the Annual Meeting. Application Deadline: October 11, 2011 Learn More >> Uniting Against Lung Cancer Legacy Program Grants UALC aims to jumpstart new projects leading to improved treatments and a cure for lung cancer, including non-small cell and small cell lung cancer
.
Proposals do not require large amounts of preliminary data, but must have a clear hypothesis and research plan to be completed within the two-year grant term.
This funding is intended primarily as seed money for promising and potentially transformative new projects, rather than funding well-developed clinical projects that already receive considerable support.
However, high risk/high reward add-on studies leveraging larger ongoing projects, or pre-existing data-sets, clinical samples, etc. are of interest.
Application Deadline: August 17, 2011 Learn More >> (PDF) |
Recent Publications Evaluation of the pharmacokinetics, preclinical and clinical efficacy of pralatrexate for the treatment of T-cell lymphoma. Foss FM. Expert Opin Drug Metab Toxicol . 2011 Jul 5.
Learn More >>
Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGF(c) chimeric protein targeting tissue factor. Cocco E, Varughese J, Buza N, Bellone S, Lin KY, Bellone M, Todeschini P, Silasi DA, Azodi M, Schwartz PE, Rutherford TJ, Carrara L, Tassi R, Pecorelli S, Lockwood CJ, Santin AD. Clin Exp Metastasis . 2011 Jul 2.
Learn More >>
Standardization of Epidermal Growth Factor Receptor (EGFR) Measurement by Quantitative Immunofluorescence and Impact on Antibody-Based Mutation Detection in Non-Small Cell Lung Cancer. Dimou A, Agarwal S, Anagnostou V, Viray H, Christensen S, Gould Rothberg B, Zolota V, Syrigos K, Rimm DL. Am J Pathol . 2011 Jun 12.
Learn More >> Medullary thyroid microcarcinoma: A population-level analysis of 310 patients. Kazaure HS, Roman SA, Sosa JA. Cancer . 2011 Jun 29.
Learn More >>
Standardization of Estrogen Receptor Measurement in Breast Cancer Suggests False-Negative Results Are a Function of Threshold Intensity Rather Than Percentage of Positive Cells. Welsh AW, Moeder CB, Kumar S, Gershkovich P, Alarid ET, Harigopal M, Haffty BG, Rimm DL. J Clin Oncol . 2011 Jun 27.
Learn More >>
Quantitation of paclitaxel and its two major metabolites using a liquid chromatography-electrospray ionization tandem mass spectrometry. Zhang W, Dutschman GE, Li X, Cheng YC. J Chromatogr B Analyt Technol Biomed Life Sci . 2011 Jul 15;879(22):2018-22.
Learn More >>
The Prognostic Importance of Midline Involvement in Oral Tongue Cancer. Lloyd S, Yu JB, Wilson LD, Judson BL, Decker RH. Am J Clin Oncol . 2011 Jun 22.
Learn More >>
Eradication of chemotherapy-resistant CD44+ human ovarian cancer stem cells in mice by intraperitoneal administration of clostridium perfringens enterotoxin. Casagrande F, Cocco E, Bellone S, Richter CE, Bellone M, Todeschini P, Siegel E, Varughese J, Arin-Silasi D, Azodi M, Rutherford TJ, Pecorelli S, Schwartz PE, Santin AD. Cancer . 2011 Jun 20.
Learn More >> Systemic therapy in hepatocellular carcinoma. Wrzesinski SH, Taddei TH, Strazzabosco M. Clin Liver Dis . 2011 May;15(2):423-41.
Learn More >>
Diabetes as a cause of clinically significant functional cobalamin deficiency. Solomon, LR Diabetes Care 2011 May;34(5):1077-80. Epub 2011 Mar 18 Learn More >> Iron-chelating therapy for transfusional iron overload. Solomon, LR N Engl J Med 2011 Apr 14;364(15): 1475-6; author reply 1477 Learn More >>
|
| |
|
Countdown to the CCSG Submission 445 days
until our CCSG
grant is due on
September 25, 2012.
|
Join Yale Cancer Center on Facebook
|
Inside Yale Cancer Center
A Purposeful Career Path to Make a Difference in Cancer Care An article by Ruth McCorkle in Cancer Nursing. In the News Read recent articles featuring experts from Yale Cancer Center. Learn More >>
Subscribe to Yale Cancer Center Answers on iTunes
Yale Cancer Center's weekly radio program on CT Public Radio is ranked number 2 in the world for cancer programs on iTunes. Subscribe to the show.
Learn More >>
Cancer Bytes
Hosted by Ellen Matloff, listen to the latest interview with Nathan: Advanced Colon Cancer at age 21 - Not your Average College Experience. Learn More >>
Yale Cancer Center Grand Rounds
Video presentations from Yale Cancer Center members are now available online.
Learn More >>
DirectConnect Archives
Learn More >>
|
Events
July 10; 6:00 PM Yale Cancer Center Answers WNPR Nutrition and Cancer Barry Boyd, MD Learn More >> July 13; 4:00 PM Epigenetics Interest Group Meeting BML 137 Learn More >> July 14; 9:00 AM Therapeutic Radiology Grand Rounds SCH LL Psychiatry and Oncology Gerard Sanacora, MD, PhD Learn More >>
July 17; 6:00 PM Yale Cancer Center Answers WNPR Cancer Care in the Older Patient Cary Gross, MD Learn More >> July 19; 2:00 PM From the Seaside to the Slopes: Implementing Sun Safety Interventions through Partnerships An NCI Research to Reality Cyber-seminar Learn More >> July 21; 12:00 PM YCC Special Seminar WWW 208 Cyclin-Dependent Kinases as Targets for Cancer Treatment Geoffrey Shapiro, MD, PhD Learn More >> (PDF) July 22; 10:00 AM Free Head and Neck Cancer Screening New Haven City Hall Learn More >> |
New Faculty Recruits (May 2009 - Present)
Anees Chagpar Surgical Oncology Sandy Chang Lab Medicine Anne Chiang Medical Oncology Lieping Chen Immunobiology Deborah Chirnomas Pediatric Oncology Suzanne Evans Therapeutic Radiology
Leonard Farber Medical Oncology Mark Faries Surgical Oncology
Bonnie Gould Rothberg Medical Oncology
Valentina Greco Genetics Stephanie Halene Hematology
Roy Herbst Medical Oncology Howard Hochster Medical Oncology Erin Hofstatter Medical Oncology Nina Horowitz Surgical Oncology Michael Hurwitz Medical Oncology Iris Isufi Hematology Benjamin Judson Otolaryngology Alfred Lee Hematology Arthur Levy Medical Oncology Miguel Materin Ophthalmology Daniel Morgensztern Medical Oncology Don Nguyen Pathology Abhijit Patel Therapeutic Radiology Nikolai Podoltsev Hematology Katie Politi Pathology Tara Sanft Medical Oncology Stacey Stein Medical Oncology Matthew Strout Hematology Narendra Wajapeyee Pathology Qin Yan Pathology |
Submissions
Please submit your recent publication and grant announcements to:
Renee Gaudette
Director, Public Affairs and Marketing
renee.gaudette@yale.edu
|
|
|
