Barbara E Ehrlich, PhD

Professor of Pharmacology and of Cellular and Molecular Physiology

Research Organizations

Cancer Center, Yale: Developmental Therapeutics

Cellular & Molecular Physiology: Neurobiology and Physiology of Synapses

Center for Polycystic Kidney Disease Research

Interdepartmental Neuroscience Program

Research Summary

The Laboratory of Molecular Hermeneutics is interested in how cells

regulate their intracellular calcium concentration. Cells use changes

in calcium as a trigger for many cellular events, including cell

growth, secretion, contraction, and neurotransmission. We have focused

on one aspect of this process, the release of calcium from

intracellular stores. We use calcium imaging combined with

electrophysiological, biochemical, and molecular techniques to study

the classes of calcium release channels known to exist inside virtually

all cells: the InsP3-gated channel, the ryanodine receptor, and

polycystin-2. Our first goal is to understand the basic question: how

is the function of these channels regulated. Our second goal is to use

the answers to the first question to understand the loss of calcium

regulation observed in disease states as seen in cells from patients

with polycystic kidney disease or leading to drug-induced neuropathy.

We hypothesize that these abnormalities in function are consequences,

at least in part, of altered intracellular calcium homeostasis and that our studies

will lead to suitable treatment regimens.

Selected Publications

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