Brian Richard Smith, MD

Professor of Laboratory Medicine, of Biomedical Engineering, of Medicine (Hematology) and of Pediatrics; Chair, Department of Laboratory Medicine

Research Interests

Biomedical Engineering; Blood; Blood Cells; Bone Marrow Cells; Curriculum; Education, Professional; Ethics; Hematology; Hematopoietic System; Hemic and Lymphatic Diseases; Immune System; Laboratories; Lymphoid Tissue; Physician's Practice Patterns; Religion and Medicine; Religion and Science; Stem Cells; Students; Students, Medical; Teaching; Medical Laboratory Science; Point-of-Care Systems; Disease Management; Diagnostic Techniques and Procedures

Research Organizations

Cancer Center, Yale: Cancer Immunology

Center for X-Linked Hypophosphatemia, Yale

Immunology and Immunotherapy

Internal Medicine

Laboratory Medicine: Clinical Hematology | Clinical Immunology | Hematology Laboratory | Immune Monitoring Core Facility

Research Summary

Dr. Smith's research laboratory primarily investigates the inflammation-coagulation interface, especially at the cellular level, i.e., the interaction of leukocytes and platelets, but also at the level of soluble mediators such as the complement system. A major interest is in relating basic biological events to human disease, for example, studying the mechanisms and consequences of platelet, leukocyte and complement activation during cardiac surgery, as a consequence of transfusion, in the pathophysiology of tumor metastasis, and in primary hematologic disorders. Because of the importance of inflammation-coagulation in the success or failure of clinically utilized biomechanical devices, the laboratory is also engaged in aspects of biomedical engineering.

In addition to these areas, Dr. Smith is involved in clinically oriented research designed to improve hematologic and immunologic diagnostics and ''personalized'' cell therapy, has published in the area of bioethics, and is engaged in educational methodology research to improve medical student education in Laboratory Medicine.

Specialized Terms: Inflammation-Coagulation Interface; Hematology; Bioethics; Biomedical Engineering; Laboratory Medicine Education; Therapeutic Pathology

Selected Publications

  • Laboratory Medicine Education at U.S. Medical Schools: A 2014 Status Report. Smith BR, Kamoun M, Hickner J. Acad Med. 2015 Jul 21. [Epub ahead of print]
  • Biosimilar biologics: never identical but close enough. Abi-Raad R, Smith BR. Transfusion. 2015 Feb;55(2):229-31. doi: 10.1111/trf.12961. No abstract available.
  • Pathology resident and fellow education in a time of disruptive technologies. Ziai JM, Smith BR. Clin Lab Med. 2012 Dec;32(4):623-38. doi: 10.1016/j.cll.2012.07.004. Review.
  • Educating medical students in laboratory medicine: a proposed curriculum. Smith BR, Aguero-Rosenfeld M, Anastasi J, Baron B, Berg A, Bock JL, Campbell S, Crookston KP, Fitzgerald R, Fung M, Haspel R, Howe JG, Jhang J, Kamoun M, Koethe S, Krasowski MD, Landry ML, Marques MB, Rinder HM, Roberts W, Schreiber WE, Spitalnik SL, Tormey CA, Wolf P, Wu YY; Academy of Clinical Laboratory Physicians and Scientists. Am J Clin Pathol. 2010 Apr;133(4):533-42. doi: 10.1309/AJCPQCT94SFERLNI.

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Contact Info

Brian Richard Smith, MD
Patient Care Location
Yale Laboratory Medicine55 Park Street, Ste Suite 218
New Haven, CT 06519
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Office Locations
Main Office, Department of Laboratory MedicineClinic Building
789 Howard Avenue, Ste Rm 407

New Haven, CT 06519
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Chair's Office, Department of Laboratory Medicine55 Park Street, Ste Rm 218
New Haven, CT 06519
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Mailing Address
PO Box 208035
New Haven, CT 06520-8035

Curriculum Vitae