Robert J Homer, MD, PhD

Professor of Pathology and of Medicine (Pulmonary); Director, Medical Student Course Module; Director of Medical Studies

Research Organizations

Cancer Center, Yale

Pathology: Thoracic and Genitourinary Translational Team

Skin Diseases Research Center, Yale

Research Summary

(1) Pathology of asthma and other inflammatory lung diseases. I am the pathology co-principle investigator on several NIH grants relating to inflammatory lung disease including emphysema. As such I select, perform, and analyze appropriate morphologic assays, primarily for light microscopy, but also for electron microscopy. Models under analysis include mice transgenic for various cytokines (IL-6 family, IL-13, IL-10), mice deficient in various cytokines or their receptors (IL-4, Stat-6, CCR2) or other mediators (MMP-9, NF-kappa B) and various adoptive transfer models. These mice are also subject to other stresses, especially hyperoxia. Some human work on isocyanate induced asthma is also ongoing.

(2) Miscellaneous interests include autopsy pathology, case reports, and quality assurance issues in pathology.

Extensive Research Description

(1) Pathology of asthma and other inflammatory lung diseases. I am the pathology co-principle investigator on several NIH grants relating to inflammatory lung disease including emphysema. As such I select, perform, and analyze appropriate morphologic assays, primarily for light microscopy, but also for electron microscopy. Models under analysis include mice transgenic for various cytokines (IL-6 family, IL-13, IL-10), mice deficient in various cytokines or their receptors (IL-4, Stat-6, CCR2) or other mediators (MMP-9, NF-kappa B) and various adoptive transfer models. These mice are also subject to other stresses, especially hyperoxia. Some human work on isocyanate induced asthma is also ongoing. 2) Miscellaneous interests include autopsy pathology, case reports, and quality assurance issues in pathology.

interstitial lung disease, asthma, emphysema, pulmonary fibrosis, animal models of lung disease

Selected Publications

Edit this profile