Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms' Tumor


Stage III Wilms Tumor With Loss of Heterozygosity (LOH) for 1p and 16q | Stage IV Wilms Tumor

What is the purpose of this trial?

This phase III trial is studying how well combination chemotherapy with or without radiation therapy works in treating young patients with newly diagnosed stage III or stage IV Favorable Histology Wilms' tumor. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving more than one drug (combination chemotherapy) with or without radiation therapy may kill more tumor cells.

Participation Guidelines

Up to 29 Years

Click here for detailed information about who can participate in this trial.

Children's Oncology Group
National Cancer Institute (NCI)
February 2007 - January 2012
Last Updated:
August 7, 2014
Study HIC#:

Clinicaltrials.gov ID: NCT00379340