Alanna Schepartz, PhD

Sterling Professor of Chemistry; Professor of Molecular, Cellular, & Developmental Biology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development: Cell Biology; Chemical Biology; Human Disease; Imaging (super-resolution); RNA Biology; Signal Transduction

Yale Cancer Center: Developmental Therapeutics

Chemical Biology Institute

Office of Cooperative Research

Faculty Research


Alanna Schepartz was born in New York City on January 9, 1962 and was graduated from Forest Hills High School in 1978. From 1978-1982 she attended the State University of New York@ Albany where she majored in Chemistry and carried out undergraduate research on organic electrochemistry with Shelton Bank. In 1982 Alanna moved back to NYC to attend graduate school at Columbia University and receivedher doctorate in 1987 for research on the mechanism of catalysis by the enzymecarboxypeptidase A. Alanna then traveled to the CaliforniaInstitute of Technology, where she developed chemical methods to explore the topology ofeukaryotic ribosomes and the interactions of ribosomal RNAs with antibiotics. In 1988 shejoined the Chemistry Department at Yale University where she is now the Milton Harris ’29 Ph.D. Professor of Chemistry and Professor of Molecular, Cellular, and Developmental Biology. Research in the Schepartz laboratory is focused on the design and synthesis of new classes of molecules that manipulate, monitor, or mimic protein–protein and protein–DNA interactions inside the cell. Current topics include the use of miniature proteins to identify thefunctional role of discrete protein-protein interactions and rewire cellular circuits, the use of cell permeable fluorescent dyes to image misfolded proteins or protein interactions in live cells, and the design of protein-like assemblies of ß-peptides that are entirely devoid of alpha aminoacids. The ß-peptide assemblies reported by the Schepartz laboratory represent thevery first example of a synthetic molecule with protein-like structure and stability.

Education & Training

PhD Columbia University, Organic Chemistry (1987)
BS State University of New York-Albany, Chemistry (1982)
NIH Postdoctoral Fellow Caltech

Honors & Recognition

  • Ronald Breslow Award for Achievement in Biomimetic Chemistry American Chemical Society (2012)

  • ACS Chemical Biology Prize & Prize Lecture American Chemical Society (2010)

  • Frank H. Westheimer Prize MedalHarvard University (2008)

  • Elected FellowAmerican Academy of Arts

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