Biophysics; DNA Damage; Lung Neoplasms; Physics; Prostatic Neoplasms; Cell Hypoxia; Radiation Oncology; Heavy Ion Radiotherapy
Therapeutic Radiology: Radiological Physics
The overall goal of my research is to develop more accurate radiobiological dose-response models that will advance biologically-guided radiation therapy (BGRT) for cancer patients. I hope to make scientific contributions to improve our basic understanding of the underlying physical and biological mechanisms that govern radiation response. Specifically, in my recent research, I have quantified the effects of the spatial pattern of energy deposition by different types of radiation on the relative biological effectiveness of x-rays, protons, and carbon ions in achieving local tumor control. I have also examined the combined effects of cellular oxygen concentration and spatial energy deposition on DNA damage formation and processing and cell death. I have a broad background in radiation physics and radiation biology. As a doctoral candidate at Purdue University, I conducted research on the mechanisms of intrinsic radiation sensitivity and examined the effects of DNA damage repair, oxygen, and radiation quality (particle LET) on biological endpoints such as double-strand break formation and cell killing. As a physics resident at Stanford University, I obtained a comprehensive understanding of the clinical application of radiation for the treatment of malignant and benign disease. I continued my research in radiobiological modeling to develop more realistic models of tumor hypoxia based on radial oxygen diffusion from tumor vasculature and the impact on radiation response. I am currently focused on (1) developing non-invasive functional imaging tools to quantify the spatial and temporal distributions of tumor hypoxia in early-stage non-small cell lung cancer and (2) implementing methods of biological optimization in heavy ion radiotherapy.
Specialized Terms: Biological optimization of radiation therapy; Tumor hypoxia and reoxygenation effects; Proton and heavy ion radiotherapy; Functional imaging; DNA damage and repair; Motion management; 4D imaging and treatment strategies; Prostate cancer; Lung cancer
Extensive Research Description
Current and Past Research Supported by:
Agency: National Institute of Health (NIH)
ID #: 3UM1CA186689 (PI: LoRusso, P.)
Project: ViKTriY Early Clinical Trials Consortium
Agency: American Cancer Society (ACS)
ID #: 128352-RSG-15-197-01-TBG (PI: Bindra, R.)
Project: Pre-clinical development of Mibefradil as a novel glioma radiosensitizer
Agency: NIH/NIAID, The Dartmouth Physically-Based Biodosimetry Center for Medical Countermeasures Against Radiation (Dart-Dose CMCR) Pilot Program
ID #: Pilot grant from U19AI1091173 (Swartz, H.)
Grant Name: Comparing In Vivo biodosimetry with EPR to independent physical dosimetry methods
Agency: Biomedical Advanced Research and Development Authority (BARDA) within the U.S. Department of Health and Human Services
ID #: Subcontract #HHSO100201100024C from Dartmouth College
Project Name: In Vivo biodosimetry using electron paramagnetic resonance (EPR) spectroscopy
Agency: Yale Comprehensive Cancer Center (YCC)
Grant Name: Non-invasive imaging of tumor hypoxia in non-small cell lung cancer patients undergoing stereotactic body radiotherapy
Agency: American Cancer Society (ACS)
ID #: IRG-58-012-52
Grant Name: Modeling relative biological effectiveness and oxygen effects in x-ray, proton, and carbon ion radiotherapy
- Mairani A, Dokic I, Magro G, Tessonnier T, Kamp F, Carlson DJ, Ciocca M, Cerutti F, Sala PR, Ferrari A, Bohlen TT, Jakel O, Parodi K, Debus J, Abdollahi A, Haberer T. Biologically optimized helium ion plans: calculation approach and its in vitro validation. Phys. Med. Biol. 61: 4283-4299 (2016).
- Song S, Hong B, Bok S, Lee C, Kim Y, Jeon S, Wu H, Lee Y, Cheon GJ, Paeng JC, Carlson DJ, Kim HJ, Ahn G. The real-time tumor oxygenation changes following a single high dose radiotherapy in orthotopic and subcutaneous lung cancers in mice: clinical implication for stereotactic ablative radiotherapy schedule optimization. Int. J. Radiat. Oncol. Biol. Phys. 95: 1022-1031 (2016).
- Kamp F, Cabal G, Mairani A, Parodi K, Wilkens JJ, Carlson DJ. Fast biological modeling for voxel-based heavy ion therapy treatment planning using the mechanistic repair-misrepair-fixation (RMF) model and nuclear fragment spectra. Int. J. Radiat. Oncol. Biol. Phys. 93: 557-568 (2015).
- Shuryak I, Carlson DJ, Brown JM, Brenner DJ. High-dose and fractionation effects in stereotactic radiation therapy: analysis of tumor control data from 2,965 patients. Radiother. Oncol. 115: 327-334 (2015).
- Polster L, Schuemann J, Rinaldi I, Burigo L, McNamara AL, Stewart RD, Attili A, Carlson DJ, Sato T, Méndez JR, Faddegon B, Perl J, Paganetti H. Extension of TOPAS for the simulation of proton radiation effects considering molecular and cellular endpoints. Phys. Med. Biol. 60: 5053-5070 (2015).
- Zheng M, Collier L, Bois F, Kelada OJ, Hammond K, Ropchan J, Akula MR , Carlson DJ, Kabalka GW, Huang Y. Synthesis of [18F]-FMISO in a flow-through microfluidic reactor: Development and clinical application. Nucl. Med. Biol. 42: 578-584 (2015).
- Brenner DJ, Carlson DJ. Radiobiological Principles Underlying Stereotactic Radiation Therapy. In Principles and Practice of Stereotactic Radiosurgery, 2nd edition, eds. Chin LS and Regine WF, Springer, p. 57-71 (2015).
- Zhang Y, Feng Y, Zhang Y, Ming X, Yu J, Carlson DJ, Kim J, Deng J. Is it the time for personalized imaging protocols in cancer radiation therapy? [editorial]. Int. J. Radiat. Oncol. Biol. Phys. 91: 659-660 (2015).
- Kelada OJ, Carlson DJ. Molecular imaging of tumor hypoxia with positron emission tomography. Radiat. Res. 181: 335-349 (2014).
- Brown JM, Carlson DJ, Brenner DJ. The tumor radiobiology of SRS and SBRT: are more than the 5 R’s involved? Int. J. Radiat. Oncol. Biol. Phys. 88: 254–262 (2014).
- Abolfath RM, Carlson DJ, Chen ZC, Nath R. A molecular dynamics simulation of DNA damage induction by ionizing radiation. Phys. Med. Biol. 58: 7143–7157 (2013).
- Brown JM, Brenner DJ, Carlson DJ. Dose escalation, not “new biology”, can account for the efficacy of stereotactic body radiotherapy (SBRT) with non-small cell lung cancer (NSCLC) [editorial]. Int. J. Radiat. Oncol. Biol. Phys. 85: 1159-1160 (2013).
- Carlson DJ, Chen ZJ, Ouhib Z, Hoskin P, Zaider M. Radiobiology for Brachytherapy. In Comprehensive Brachytherapy: Physical and Clinical Aspects, eds. Venselaar J, Soleimani-Meigooni A, Baltas D, Hoskin P, CRC Press, Taylor and Francis Group, p. 253-270 (2013).
- Frese MC, Yu VK, Stewart RD, Carlson DJ. A mechanism-based approach to predict the relative biological effectiveness (RBE) of protons and carbon ions in radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 83: 442-450 (2012).
- Carlson DJ, Keall PJ, Loo BW, Chen ZJ, Brown JM. Hypofractionation results in reduced tumor cell kill compared to conventional fractionation for tumors with regions of hypoxia. Int. J. Radiat. Oncol. Biol. Phys. 79: 1188-1195 (2011).
- Carlson DJ, Yenice KM, Orton CG. Point/Counterpoint: Tumor hypoxia is an important mechanism of radioresistance in hypofractionated radiotherapy and must be considered in the treatment planning process. Med. Phys. 38: 6347-6350 (2011).
- Stewart RD, Yu VK, Georgakilas AG, Koumenis C, Park JH, Carlson DJ. Effects of Radiation Quality and Oxygen on Clustered DNA Lesions and Cell Death. Radiat. Res. 176: 587-602 (2011).
- Stewart RD, Park J, Carlson DJ. Isoeffect Calculations in Adaptive Radiation Therapy and Treatment Individualization. In Adaptive Radiation Therapy, a volume in a series of books on Imaging in Medical Diagnosis and Therapy, ed. X. Allen Li, CRC Press, Taylor and Francis Group, p. 105-123 (2011).
- Gupta S, Wu X, Carlson DJ, Kolesnick R, Mohiuddin M, Pollack A, Ahmed MA. Radiobiological concepts of high-dose hypofractionated radiation therapy. In Hypofractionation: Scientific Concepts and Clinical Experiences, eds. Pollack A and Ahmed MA, LumiText Publishing, p. 19-38 (2011).
- Zimmerman J, Korreman S, Persson G, Cattell H, Svatos M, Sawant A, Venkat R, Carlson D, Keall P. DMLC motion tracking of moving targets for intensity modulated arc therapy treatment: a feasibility study. Acta Oncol. 48: 245-250 (2009).
- Carlson DJ, Stewart RD, Semenenko VA. Effects of oxygen on intrinsic radiation sensitivity: A test of the relationship between aerobic and hypoxic linear-quadratic (LQ) model parameters. Med. Phys. 33: 3105–3115 (2006).
- Sawant A, Venkat R, Srivastava V, Carlson D, Povzner S, Cattell H, Keall P. Management of three-dimensional intrafraction motion through real-time DMLC tracking. Med. Phys. 35: 2050-2061 (2008).
- Carlson DJ, Stewart RD, Semenenko VA Sandison GA. Combined use of Monte Carlo DNA damage simulations and deterministic repair models to examine putative mechanisms of cell killing. Radiat. Res. 169: 447-459 (2008).
- Carlson DJ, Stewart RD, Li XA, Jennings K, Wang JZ, Guerrero M. Comparison of in vitro and in vivo a/ß ratios for prostate cancer. Phys. Med. Biol. 49: 4477–4491 (2004).