David G. Schatz PhD
Professor of Immunobiology and of Molecular Biophysics and Biochemistry; Professor of Molecular Biophysics and Biochemistry
Departments & Organizations
Yale Combined Program in the Biological and Biomedical Sciences (BBS): Immunology | Molecular Cell Biology, Genetics and Development | Biochemistry, Biophysics and Structural Biology
Immunobiology: Lymphocyte Development
Molecular Biophysics and Biochemistry
Immunology and Immunotherapy
Biochemical mechanism and developmental regulation of V(D)J recombination and somatic hypermutation; Lymphocyte development; Mechanisms of DNA repair; Function of the RAG1 and RAG2 proteins; Mechanisms of lymphomagenesis more...
- Ph.D., Massachusetts Institute of Technology, 1990
- Ji, Y., Resch, W., Corbett, E., Yamane, A., Casellas, R., and Schatz, D.G. (2010). The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci. Cell 141, 419-431.
- Liu, M., Duke, J. L., Richter, D. J., Vinuesa, C. G., Goodnow, C. C., Kleinstein, S. H. and Schatz, D. G. Two levels of protection for the B cell genome during somatic hypermutation. Nature 451, 841-845 (2008)
- Yin, F.F., Bailey, S., Innis, C.A., Ciubotaru, M., Kamtekar, S., Steitz, T.A., and Schatz, D.G. (2009). Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nat Struct Mol Biol 16, 499-508.