Inflammation; Lung Neoplasms; Neoplasm Metastasis; Neoplasm Micrometastasis
Public Health Interests
Cancer genetics; Genomics
Stem Cell Center, Yale: Stem Cell Niche and Homing | Transcriptional Regulation of Stem and Progenitor Cells
Cancer metastasis remains an unresolved clinical and biological problem. This is particularly relevant in the case of thoracic malignancies, which can spread aggressively to multiple distant organs with limited opportunity for effective therapeutic intervention. Metastatic lung cancer cells are believed to acquire complex biological properties by deregulating pleiotoropic genetic programs and interacting with their microenvironment. My laboratory is interested in uncovering the molecular, cellular, and physiological determinants of metastasis by different lung cancers. In this endeavor, we utilize a variety of approaches such as animal modeling, cell biology, bioinformatics, and clinical validation.
- Cheung, W.K.C., Zhao, M., Liu, Z., Stevens, L.E., Cao, P.D., Fang, J.E., Westbrook, T.F., and Nguyen, D.X. (2013). Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis. Cancer Cell, 23 (6): 725-738. Featured article.
- Nguyen DX. (2011). Tracing the origins of metastasis. J Pathol. 223(2): 196-205.
- Nguyen, D.X., Chiang, A.C., Zhang, H.F.X., Kim, J.Y., Kris, M.G., Ladanyi, M., Gerald, W.L., and Massague, J. WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell, 138(1): 51-62 (2009).
- Kim, M-Y., Oskarsson, T., Acharyya, S., Nguyen, D.X., Zhang, X-F., Norton, L., and Massague, J. Tumor self-seeding by circulating cancer cells. Cell, 139 (7): 1315-1326 (2009).
- Bos, P.D., Zhang, H.F.X., Nadal, C., Shu. W., Gomis. R.R., Nguyen, D.X., Minn, A.J., Van de Vijver, M., Gerald, W.L., Foekens, J.A., and Massague, J. Genes that mediate metastasis through the blood-brain barrier. Nature, 459: 1005-9 (2009).
- 4. Gupta, G.P.*, Nguyen, D.X.*, Chiang, A.C., Bos, P.D., Kim, J.Y., Nadal, C., Shu, W., Gomis, R.R., Todorova-Manova, K., and Massagué, J. (2007). Mediators of vascular remodeling co-opted for sequential steps in lung metastasis. Nature, 446: 765–770. *A