Elizabeth Brooks Claus, PhD, MD

Professor of Public Health (Biostatistics); Director of Medical Research, School of Public Health; Director of Stereotactic Radiosurgery, Department of Neurosurgery, Brigham and Women's Hospital

Research Interests

Breast Neoplasms; Epidemiology; Meningioma; Neurosurgery; Statistics as Topic; Central Nervous System Neoplasms

Public Health Interests

Biostatistics; BRAC1; BRAC2; Breast cancer; Cancer Epidemiology; Genetic epidemiology; Glioma; Meningioma; Neuroepidemiology; Risk assessment; Statistical genetics

Research Organizations

Cancer Center, Yale: Cancer Prevention and Control

Cancer Genetics

School of Public Health

Research Summary

Dr. Claus works in cancer epidemiology and statistical genetics with emphasis on the development of risk models for breast and ovarian cancer and tumors of the central nervous system (CNS). She is principal investigator of a study of 2000 female Connecticut residents examining the clinical (including mammographic density), genetic, and epidemiologic characteristics of breast carcinoma in-situ (BCIS), and following these women over time to better define their long-term outcomes, including those with mutations in two breast cancer susceptibility genes, BRCA1 and BRCA2. Dr. Claus is a neurosurgeon working in neuro-oncologic surgery, including the intra-operative use of magnetic resonance therapy and computer guided imagery for brain tumor removal, including glioma and metastatic lesions to the CNS, particularly metastatic breast cancer. She has recently received funding from NIH to commence the first national study of meningioma. This multi-state project will enroll over 3000 subjects to define genetic and environmental risk factors for meingioma as well as identify pedigrees with multiple family members affected with meningioma. Dr. Claus is also co-investigator in the GLIOGENE project, an international effort to identify genes associated with glioma. More recently, Dr Claus has begun to partner with a number of national patient organizations (The Acoustic Neuroma Association and The American Brain Tumor Association) to develop patient-centered, web-based registries designed to enhance research and patient education efforts in the study of tumors of the central nervous system. In addition to her research activities,

Extensive Research Description

  • The Yale Breast Study
  • The DCIS and BRCA1/2 Cohort Study
  • The Meningioma Consortium Project
  • The Meningioma Family Study
  • The Meningioma Genome-Wide Association Study
  • GLIOGENE (Genes for Glioma)
  • The International Glioma Case/Control Study (GICC)
  • The Yale Acoustic Neuroma Study
  • The International Low Grade Glioma Project

Selected Publications

Edit this profile

Contact Info

Elizabeth Brooks Claus, PhD, MD
Office Location
Laboratory of Epidemiology and Public Health
60 College Street, Ste 205

New Haven, CT 06510
Mailing Address
PO Box 208034
60 College Street

New Haven, CT 06520-8034

Yale Acoustic Neuroma Study

Research Image 1

This first issue of the magazine focused on brain tumor epidemiology at the Yale School of Public Health