Program Members
Co-Leaders
Lajos Pusztai
Co-Director, Cancer Genetics Research Program
Professor of Medicine, Director of Breast Medical Oncology Section
Clinical Interests:breast cancer; cancer genetics.
- Appt:(203) 200-2328
Members
Allen Bale
Professor of Genetics
Director, DNA Diagnostic Lab
Research Interests:Molecular Mechanisms of Cancer; Predisposition and Developmental Defects; DNA Diagnostics; Birth Defects; Cancer; Fanconi; Genetics; Hedgehog; Multiple Endocrine Neoplasia; Patched; Skin Cancer; Tumor Suppressor
Susan Baserga
Professor of Molecular Biophysics and Biochemistry, of Genetics and of Therapeutic Radiology
Research Interests:Ribosome biogenesis; rRNA processing; U3 RNP structure and function; RNA helicases; Polymerase I transcription and processing
Jean Bolognia
Professor of Dermatology
Director, Pigment Lesion Clinic
Vice Chair, Clinical Affairs
Research Interests:Clinicopathologic correlations regarding various types of melanocytic nevi (moles) and melanoma; cutaneous side effects of chemotherapy
- Office:(203) 785-4092
- Appt:(203) 789-1249
Marcus Bosenberg
Associate Professor of Dermatology and of Pathology
Research Interests:Melanocytic neoplasms; soft tissue tumors; cutaneous lymphoma; genodermatoses
- Office:(203) 737-3484
- Appt:(203) 785-4094
Demetrios Braddock
Associate Professor of Pathology
Research Interests:Structural biology; Hematopathology; Genitourinary Pathology
- Office:(203) 737-1278
- Lab:(203) 737-4277
- Appt:(203) 785-6828
Tobias Carling
Assistant Professor of Surgery (Endocrine Surgery)
Section Chief
Director, Yale Endocrine Neoplasia Laboratory
Research Interests:improved outcomes in minimally invasive endocrine surgery; molecular genetics of endocrine tumors of the thyroid, parathyroid, adrenal (hyperaldosteronism, hypercortisolism, adrenal cancer, pheochromocytoma) and endocrine pancreas; familial endocrine tumor susceptibility syndromes; regulation of calcium homeostasis
- Appt:(203) 737-2036
Jose Costa
Professor of Pathology and of Medicine (Medical Oncology)
Director, Translational Diagnostics
Director, Musculoskeletal Tumor Program
Research Interests:Oncology; Carcinogenesis; Tumor development and progression; Advanced diagnostics; Molecular diagnostics; Diagnosed genetic alterations in tumors; Cancer risk detection by mutational load distribution analysis
- Office:(203) 785-5803
- Appt:(203) 785-5803
Bernard Forget
Professor Emeritus of Medicine (Hematology) and Professor of Genetics and of Medicine (Hematology)
Research Interests:Molecular Genetics of Erythroid Cell Differentiation; Hematopoietic Stem Cell Biology
- Office:(203) 785-7002
- Lab:(203) 785-4154
- Appt:(203) 785-4744
Alan Garen
Professor of Molecular Biophysics and Biochemistry
Research Interests:Development; Genetics; Medical Sciences; Molecular Biology
Antonio Giraldez
Associate Professor of Genetics
Member of the Yale Cancer Center
Member of the Stem Cell Center
Director of Graduate Studies
Research Interests:Non-coding RNAs, Post-transcriptional regulation; microRNAs; Developmental Biology; Gene regulatory networks; Systems Biology; Zebrafish
- Office:(203) 785-5423
Murat Gunel
Nixdorff-German Professor of Neurosurgery and Professor of Genetics and of Neurobiology
Co-Director, Yale Program on Neurogenetics
Director, Neurovascular Surgery
Research Interests:Molecular genetics and biology of brain aneurysms and cavernous malformations; molecular genetics of brain development
- Office:(203) 737-2096
- Appt:(203) 737-2096
Ruth Halaban
Senior Research Scientist in Dermatology
Research Interests:Genes controlling differentiation, proliferation and malignant transformation of melanocytes; growth factors and receptor kinases; signal transduction; epigenetic modification and gene expression; markers for melanoma
- Office:(203) 785-4352
Stephanie Halene
Assistant Professor of Medicine (Hematology)
Research Interests:Hematopoiesis; Myeloid differentiation; Leukemia; Myelodysplasia
- Appt:(203) 200-4363
Josephine Hoh
Associate Professor of Epidemiology (Environmental Health) and of Ophthalmology and Visual Science
Research Interests:Interactions among genes; Environmental exposures
- Office:(203) 785-2738
- Lab:(203) 737-6007
Natalia Ivanova
Assistant Professor of Genetics
Research Interests:Embryonic and somatic stem cells; Vertebrate development; Functional genomics; Systems biology
Kenneth Kidd
Professor of Genetics, of Ecology and Evolutionary Biology and of Psychiatry
Research Interests:Complex Human Disorders; Neuropsychiatric Disorders; Human Population ; Genetics; Human Evolution
- Office:(203) 785-2654
- Lab:(203) 785-2653
Tae Hoon Kim
Assistant Professor of Genetics
Member, Yale Cancer Center
Member, Yale Stem Cell Center
Research Interests:Transcriptional Regulatory Elements and Chromatin Structure; Expression of the Cancer Genome; Epigenomics
Yuval Kluger
Associate Professor of Pathology
Research Interests:Signal processing and dimensional reduction of genome-wide data; Local and non-local genomic pattern recognition; Identification of cancer subclones with proliferation and invasion potential in heterogeneous cancer biopsies
William Konigsberg
Professor of Molecular Biophysics and Biochemistry
Research Interests:Blood Coagulation; DNA Replication; Genetics; Proteins and Macromolecules
Diane Krause
Professor of Laboratory Medicine, of Cell Biology and of Pathology
Assoc. Director, Yale Stem Cell Center
Assoc. Director, Transfusion Medicine Service
Director, Frisbee Laboratory for Hematopoietic Graft Engineering
Research Interests:Bone Marrow Transplantation; Stem Cells; Cell and Molecular Hematology; Leukemia
- Office:(203) 737-1678
Gary Kupfer
Professor of Pediatrics (Hematology / Oncology) and of Pathology
Clinical Program Leader, Pediatric Hematology & Oncology Program, Smilow Cancer Hospital
Section Chief, Pediatric Hematology/Oncology
Clinical Research Program Leader, Pediatric Hematology & Oncology Program, Yale Cancer Center
Research Interests:Genomic instability; Development of cancer; Genetic syndrome Fanconi anemia (FA); Viral protein enhancement of cancer therapeutics
- Office:(203) 785-4640
- Appt:(203) 785-4640
Rossitza Lazova
Associate Professor of Dermatology and of Pathology
Director, Yale Dermatopathology Fellowship
Research Interests:Spitz nevi; Spitzoid melanocytic neoplasms; Malignant melanoma; Melanocytic nevi on special anatomic sites
- Office:(203) 785-4094
- Appt:(203) 785-4094
David Leffell
David P. Smith Professor of Dermatology and Professor of Surgery (Otolaryngology and Plastic)
Deputy Dean for Clinical Affairs, Yale School of Medicine
Section Chief, Dermatologic Surgery and Cutaneous Oncology
Research Interests:Molecular biology of basal cell carcinoma and squamous cell carcinoma; wound healing; skin cancer epidemiology
- Office:(203) 785-7999
- Appt:(203) 785-3466
Peter Lengyel
Professor Emeritus of Molecular Biophysics and Biochemistry
Research Interests:p200 family proteins; mammalian differentiation; cell proliferation; interferons
Peining Li
Associate Professor of Genetics
Research Interests:Cytogenetic and genomic analysis; Dissection of genetic mechanisms for growth regulation, mental development, and cancer progression
- Office:(203) 785-6317
- Appt:(203) 785-6317
Richard Lifton
Sterling Professor of Genetics and Professor of Medicine (Nephrology)
Chair, Department of Genetics
Investigator, Howard Hughes Medical Institute
Research Interests:Molecular genetics of common human diseases
Haifan Lin
Professor of Cell Biology and of Genetics
Director, Yale Stem Cell Center
Research Interests:RNA-mediated epigenetic programming and post-transcriptional regulation of stem cells
- Office:(203) 785-6239
- Lab:(203) 785-6215
Paul Lizardi
Professor of Pathology
Research Interests:Cancer Genetics/Epigenetics; Cancer biology; Dynamics of abnormal chromatin states in neoplasia and metastasis; DNA amplification technology (MDA, RCA); DNA microarray technology for epigenetic analysis, array-CGH; Proteomics analysis of cancer tissues
Jun Lu
Assistant Professor of Genetics
Research Interests:Non-coding RNAs in blood stem cell differentiation and malignancies; MicroRNA-mediated control of embryonic stem cell fates; MicroRNA mechanisms
- Office:(203) 737-3426
Shrikant Mane
Senior Research Scientist in Genetics
Co-Director, MBB Keck Biotech Services
Director, Yale Center for Genome Analysis
- Office:(203) 737-3104
- Lab:(203) 737-3058
Miguel Materin
Associate Professor of Ophthalmology and Visual Science
Director of Ophthalmic Oncology
Research Interests:Role of cytogenetics in ocular oncology for diagnosis and prognosis; improving diagnostic and treatment methods for eye tumors
- Appt:(203) 785-2020
Ellen Matloff
Research Scientist in Genetics
Director, Cancer Genetic Counseling
Research Interests:BRCA1; BRCA2; HNPCC; hereditary cancer; genetic patents; genetic counseling; genetic testing; sexuality and cancer; providers of genetic counseling
- Office:(203) 764-8405
- Appt:(203) 764-8400
James McGrath
Research Scientist in Comparative Medicine, in Genetics and in Pediatrics
Research Interests:Developmental Genetics; Genetic Imprinting; Embryogenesis; Spermatogenesis
- Office:(203) 785-2686
- Appt:(203) 785-2660
James Noonan
Assistant Professor of Genetics
Member, Kavli Institute for Neuroscience
Member, Yale Cancer Center
Research Interests:Human Evolution; Evolutionary Dynamics of Gene Regulation; Synthetic Biology; Applications of Ultra-High Throughput Sequencing Technologies; Comparative and Functional Genomics in Vertebrates
Manju Prasad
Associate Professor of Pathology and of Surgery (Otolaryngology)
Director, Endocrine, Head & Neck Pathology
Director, Immunohistochemistry Laboratory
Director, Endocrine, Head and Neck Pathology Fellowship
Research Interests:Endocrine, Head & Neck Pathology; Genotype-phenotype correlation in tumors; Protein expression and biomarkers in tumor tissues, and their diagnostic & prognostic relevance
Lajos Pusztai
Co-Director, Cancer Genetics Research Program
Professor of Medicine, Director of Breast Medical Oncology Section
Research Interests:breast cancer; translational cancer research; developing pharmacogenomic markers of response to breast cancer therapy and identifying methods to select the optimal treatment for each patient
- Appt:(203) 200-2328
Peter Schwartz
John Slade Ely Professor of Obstetrics, Gynecology, and Reproductive Sciences
Vice Chair, Gynecology
Research Interests:Ovarian Cancer, uterine, vaginal, cervical and vulvar cancer. Screening for ovarian cancer.
- Office:(203) 785-4014
- Appt:(203) 785-4014
Gerald Shadel
Professor of Pathology and of Genetics
Director, Pathology Research
Research Interests:Mitochondria; Mitochondrial Genetics and Biogenesis; Mitochondrial Dysfunction in Human Disease and Aging; Mechanisms of mtDNA Transcription and Mitochondrial Translation; Signaling Pathways that Sense and Control Mitochondrial Function; Cancer; Immune System Signaling
Jeffrey Sklar
Professor of Pathology and of Laboratory Medicine
Director, Molecular Diagnostics Program
Director, Molecular Genetics Pathology Fellowship
Director, Molecular Tumor Profiling Laboratory
Director of Molecular and Genomic Pathology
Research Interests:Molecular biology of human disease, especially cancer; Molecular biologic methods of disease diagnosis; Cancer-related genes and their functions in neoplasia and normal cellular physiology; Chromosomal structure and chromosomal abnormalities in genetic and neoplastic disorders; Immunogenetics
- Office:(203) 785-6828
- Appt:(203) 737-6012
Matthew Strout
Assistant Professor of Medicine (Hematology)
Research Interests:Cancer genetics; Lymphomagenesis; Leukemogenesis; Immune diversification; Epigenetics; Tissue banking; Targeted therapy
- Office:(203) 785-7002
- Lab:(203) 737-6425
- Appt:(203) 200-4363
Hugh Taylor
Anita O'Keeffe Young Professor of Obstetrics, Gynecology, and Reproductive Sciences and Professor of Molecular, Cellular, and Developmental Biology
Chief of Obstetrics and Gynecology, Yale-New Haven Hospital
Anita O'Keeffe Young Professor of Women's Health, Yale University
Research Interests:Homeobox genes; Embryo implantation; Endometriosis; Stem cells; Menopause; uterine Development; Endocrine disruption; Developmental programming
- Office:(203) 785-4001
- Appt:(203) 785-4708
Robert Udelsman
William H. Carmalt Professor of Surgery
Chair, Department of Surgery
Surgeon-in-Chief, Yale-New Haven Hospital
Clinical Program Leader, Endocrine Cancers Program, Smilow Cancer Hospital
Research Interests:Minimally invasive surgery, including techniques for minimizing the trauma of surgery; endocrine surgery, particularly endocrine oncology
- Office:(203) 785-2697
- Appt:(203) 785-2697
Sherman Weissman
Sterling Professor of Genetics
Research Interests:Globin and Histocompatibility Gene Structure and Function; Genome wide mapping of gene activity and chromosome structure in man; Transcription Factors; Lymphocyte and myeloid Transcription Networks; Stem Cells; Cell Senescence; Methods for Molecular Genetics
- Office:(203) 737-2281
Andrew Xiao
Assistant Professor of Genetics
Research Interests:Chromatin biology: histone variants, modifications and chromatin remodeling complexes; Cellular reprogramming (iPS) and stem cell biology; Mammalian neural crest cell; Mammalian DNA damage response
- Office:(203) 737-3650
- Lab:(203) 785-5111
Mina Xu
Assistant Professor of Pathology and of Laboratory Medicine
Research Interests:Peripheral T-cell lymphoma, NOS; Classical hodgkin lymphoma; Hemophagocytic lymphohistiocytosis, EBV-related lymphoproliferative disorders
- Appt:(203) 785-3624
Tian Xu
Professor of Genetics
Vice Chairman of Genetics
Investigator, Howard Hughes Medical Institute
Research Interests:Genetic methodology; Cancer biology; Food and metabolism; Developmental mechanisms
Qin Yan
Assistant Professor of Pathology
Research Interests:Epigenetics; Transcription regulation; Cancer biology; Stem cell biology
- Office:(203) 785-6672
- Lab:(203) 785-6496
Hongyu Zhao
Ira V. Hiscock Professor of Public Health (Biostatistics) and Professor of Genetics and of Statistics
Research Interests:statistical genomics; computational biology; genetic epidemiology; genome wide association studies; complex diseases; risk prediction; high dimensional data; dimension reduction; network models; graphical models; bioinformatics; next generation sequencing analysis; cancer genomics; epigenetics; herbal medicine; microbiome; proteomics
