Joseph Schlessinger PhD, MSc

William H. Prusoff Professor of Pharmacology; Chair, Pharmacology; Director, Cancer Biology Institute

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Biochemistry, Biophysics and Structural Biology

Office of Student ResearchSignal TransductionStructural BiologyPharmacology: Schlessinger LabDiabetes Research CenterCenter for X-Linked Hypophosphatemia, Yale

Research Interests

Growth factor receptors; Intracellular signaling pathways; Protein kinases; Phosphorylation; SH2, SH3 and other protein modules involved in signal transduction; Drug discovery more...


  • B.S., Hebrew University of Jerusalem, 1968
  • M.Sc., Hebrew University of Jerusalem, 1969
  • Ph.D., Weizmann Institute of Science, Isarel, 1974

Selected Publications

  • M.A. Lemmon and J. Schlessinger. Cell signaling by receptor tyrosine kinases. Cell 141, 1117-1134 (2010).
  • J.H. Bae, T.J. Boggon, F. Tomé, V. Mandiyan, I. Lax, and J. Schlessinger. An asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells. Proc. Natl. Acad. Sci. USA 107, 2866-2871 (2010).
  • J.H. Bae, E.D. Lew, S. Yuzawa, F. Tome, I. Lax, and J. Schlessinger. The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site. Cell 138, 514-524 (2009).



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