Karl L. Insogna MD

Professor of Medicine (Endocrinology); Director, Yale Bone Center

Departments & Organizations

Cancer Center, Yale: Signal Transduction

Internal Medicine: Endocrinology: Bone Center | Diabetes Research Center | Yale Core Center for Musculoskeletal Disorders | National Gaucher Disease Treatment Center

Center for X-Linked Hypophosphatemia, Yale

Immunology and Immunotherapy

Research Interests

Role of dietary protein in skeletal metabolism; Factors that lead to skeletal disease in adult patients with X-linked hypophosphatemic rickets; Cellular mechanisms of PTH-induced bone resorption and bone anabolism; Effects of CSF1 in mature osteoclasts more...


  • M.D., University of Connecticut, 1976

Selected Publications

  • Surdykowski A, Kenny A, Insogna K, Kerstetter J. Optimizing bone health in older adults: the importance of dietary protein. Aging Health 6 (3): 345-357, 2010. PMID 20657805
  • Insogna KL. The effect of proton pump-inhibiting drugs on mineral metabolism Am J Gastroenterol. 104 Suppl 2:S2-4. 2009. PMID: 19262542
  • Gaffney-Stomberg, Insogna K, Rodriguez N, Kerstetter J. Increasing dietary protein requirements in elderly people for optimal muscle and bone health. J. Amer. Geriatric Society. 57:1073–1079, 2009. PMID: 19460090



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