Mark Simon Kidd PhD

Research Scientist in Surgery (Gastrointestinal)

Research Interests

Gastrointestinal neuroendocrine cell function

Research Summary

Regulation of gastrointestinal neuroendocrine cell function (chemomechanosensing) and transformation.

Extensive Research Description

The overall specific research areas are in brief as follows:
In the stomach, the elucidation of the growth factor-mediated transformation process of the enterochromaffin-like cell (ECL) in the Mastomys model of gastric neoplasia, as well as identification of potential therapeutic targets for Type I and III gastric neuroendocrine tumors.
In the small intestine and rectum, the delineation of tissue molecular signatures that define neuroendocrine tumor behavior (proliferation, secretion and metastasis) and can be used in predictive and prognostic models. Establishment of neuroendocrine tumor cell lines, development of novel 2- and 3-cell type models and the identification of targets in the microenvironment that can be used to modify neuroendocrine tumor behavior (fibrosis and metastasis). Development of nomograms that can be used prognostically to predict patient survival or response to therapy.
Established methodologies currently utilized include neuroendocrine cell isolation and enrichment, cell culture and in vitro analysis, microarray profiling and sequencing of rodent and human samples, real-time PCR, tissue microarray construction and analysis, and biostatistical data evaluation.

Selected Publications

  • Kidd M, Gustafsson BI, Drozdov I, Modlin IM. Serotonin secretion from Crohn’s disease EC cells is increased and mediated by IL1beta and LPS through TOLL receptor 4 (TLR4) activation of NFkB. Neurogastroenterology & Motility 2009; 21: 439-50.
  • Kidd M, Hauso Ø, Drozdov I, Gustafsson BI, Modlin IM. Delineation of the chemomechanosensory regulation of gastrin secretion using pure rodent G cells. Gastroenterology 2009; 137:231-41.
  • Drozdov I, Kidd M, Gustafsson BI, Svejda B, Joseph R, Pfragner R, Modlin IM. Auto-regulatory Effects of Serotonin on the Proliferation and Associated Signaling Pathway of Lung and Small Intestine Neuroendocrine Cell Lines Cancer 2009;115:4934-45.
  • Svejda B, Kidd M, Giovinazzo F, Eltawil K, Gustafsson BI, Pfragner R, Modlin IM. The 5-HT2B receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment. Cancer 2010; 116:2902-12.

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