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Program Members

Co-Leaders

Petrylak, Daniel

Clinical Interests:genitourinary cancer; prostate cancer; clinical trials for men with prostate and bladder cancer.

  • Office:(203) 737-8076
  • Appt:(203) 200-4822

Stern, David F.

  • Office:(203) 785-4832
  • Lab:(203) 785-6496

Members

Bennett, Anton M.

Research Interests:Signal transduction; Protein tyrosine phosphatases; Cancer; Diabetes; Obesity; Muscle stem cells; Muscular dystrophy

  • Office:(203) 737-2441
  • Lab:(203) 785-4395

Boggon, Titus

Research Interests:Structural biology of signal transduction

  • Office:(203) 785-2943
  • Lab:(203) 785-7274

Calderwood, David A.

Research Interests:Integrin; Cell adhesion; Cell migration; Cytoskeleton; Structural biology

  • Office:(203) 737-2311
  • Lab:(203) 785-2871

Cantley, Lloyd Garnet

Research Interests:Nephrology; Acute Kidney Injury; Physiology and integrative medical biology; Epithelial cell migration and morphogenesis; Epithelial cell adhesion; Migration; Branching tubulogenesis

  • Office:(203) 785-4186
  • Lab:(203) 785-7111

De Camilli, Pietro

Research Interests:Synapses; Exocytosis; Endocytosis; Membranes; Clathrin; Dynamin; Phosphoinositides; Lowe syndrome; BAR proteins; Neurodegeneration

  • Office:(203) 737-4461
  • Lab:(203) 737-4457

DiGiovanna, Michael P

Research Interests:Breast cancer; HER-2/neu/ErbB-2; IGF1 receptor; EGF receptor; Growth factor receptor tyrosine protein kinases in malignancy; Estrogen receptor, Signal transduction, breast cancer clinical trials

  • Office:(203) 785-2360
  • Lab:(203) 785-5365
  • Appt:(203) 200-2328

Geibel, John P

Research Interests:Gastric Acid Secretion; Colonic Fluid Transport; Renal Physiology; Intracellular Ion Activity Measurements; Calcium Sensing Receptor; Diarrheal disease, electrophysiology; CFTR; AMPKinase volume regulation

  • Office:(203) 737-4152
  • Lab:(203) 737-1485

Greco, Valentina

Research Interests:Organ regeneration in vertebrate systems; Stem cells; Stem cell niche organization; Cancer

    Grutzendler, Jaime

    Research Interests:Neuro-glio-vascular interactions, cerebral blood flow and metabolism blood-brain barrier, two-photon microscopy, myelin imaging, synaptic plasticity, development and pathology of the brain microvasculature, Neuroinflammationin, neurodegenerative diseases and stroke

    • Lab:(203) 737-3514
    • Appt:(203) 737-8859

    Hochstrasser, Mark W

    Research Interests:Adenosinetriphosphatase; Cell Growth Regulation; Chemical Cleavage; Chemical Conjugate; Chimeric Protein; Enzyme Activity; Enzyme Complex; Enzyme Mechanism; Enzyme Structure; Fungal Genetics; Gene Deletion Mutation; Immunoelectron Microscopy; Isozyme; Mass Spectrometry; Mutant; Proteasome; Protein Degradation; Protein Purification; Proteinase; Protooncogene; Saccharomyces Cerevisiae; Transcription Factor; Ubiquitin

      Insogna, Karl L.

      Research Interests:Role of dietary protein in skeletal metabolism; Factors that lead to skeletal disease in adult patients with X-linked hypophosphatemic rickets; Cellular mechanisms of PTH-induced bone resorption and bone anabolism; Effects of CSF1 in mature osteoclasts

      • Office:(203) 737-2871
      • Lab:(203) 737-2871
      • Appt:(203) 737-1058

      Jo, Hakryul

      Research Interests:Natural and synthetic chemicals; Cancer; Age-related macular degeneration; neuroinflammation and neurodegeneration; mitochondrial diseases

        Kibbey, Richard Glenn

        Research Interests:Mechanisms of insulin secretion by beta-cells; Pathogenesis of beta-cell exhaustion in Type 2 Diabetes Mellitus; Mitochondria

        • Office:(203) 737-4055
        • Appt:(203) 432-0038

        Kim, Joseph W

        • Appt:(203) 200-4822

        Koleske, Anthony J

        Research Interests:Neuronal morphogenesis and degeneration; Stress; Schizophrenia; Cell migration; Cancer; Metastasis; Adhesion receptors

        • Office:(203) 785-5624
        • Lab:(203) 785-5631

        Krauthammer, Michael Oliver

        Research Interests:Molecular interaction networks, computational analysis, pathway discovery, knowledge representation; Statistical modeling and analysis; Text mining in biology, term identification, information extraction

          Madri, Joseph Anthony

          Research Interests:Connective tissue disorders; Cell-Matrix and Cell-Cell Interactions; Integrin-Mediated Signaling; Cardio-vascular and neuro-vascular development; Angiogenesis and Vascular Biology; inflammation; T-cell–Endothelial cell interactions

          • Office:(203) 785-2763
          • Appt:(203) 785-2783

          Min, Wang

          Research Interests:Inflammation; Angiogenesis/lymphangiogenesis; Atherosclerosis; Transplant rejection; Tumor microenvironment and metastasis

            Morrow, Jon Stanley

            Research Interests:Hemolytic Disease; Degenerative Brain Disease; spectrin; Autopsy Pathology; Renal Pathology; Medical Informatics; Computer Aided Instruction (CAI); Telepathology

            • Office:(203) 785-3624
            • Lab:(203) 785-2771
            • Appt:(203) 785-3624

            Nguyen, Don

            Research Interests:Metastasis; Lung cancer; Cancer genomics; Tumor microenvironment

            • Office:(203) 737-4514

            Petrylak, Daniel

            Research Interests:Clinical trials for prostate and bladder cancers

            • Office:(203) 737-8076
            • Appt:(203) 200-4822

            Politi, Katerina

            Research Interests:Cancer biology; Mouse models of lung cancer; Epidermal Growth Factor Receptor; ERBB Receptor family; Targeted therapy

              Rimm, David L

              Research Interests:Quantitative Pathology; Cancer Tissue Biomarkers; Melanoma; Breast Cancer; Cell-cell adhesion in cancer; Translation of molecular techniques to diagnostic cytopathology; General Cytopathology; Immunohistochemistry; thyroid pathology

              • Office:(203) 737-4204
              • Appt:(203) 737-4204

              Schlessinger, Joseph

              Research Interests:Growth factor receptors; Intracellular signaling pathways; Protein kinases; Phosphorylation; SH2, SH3 and other protein modules involved in signal transduction; Drug discovery

              • Office:(203) 785-7395
              • Lab:(203) 785-7382

              Solomon, Mark J

              Research Interests:Cell cycle; Ubiquitin-mediated proteolysis; Anaphase-promoting Complex

              • Office:(203) 436-9053

              Stern, David F.

              Research Interests:Cancer Biology; Signal transduction by HER2/ErbB2 and other EGF family receptor tyrosine kinases; EGF family receptors in breast cancer and mammary development; DNA damage checkpoint signaling; Functional and genetic analysis of cancer; Melanoma

              • Office:(203) 785-4832
              • Lab:(203) 785-6496

              Toomre, Derek K.

              Research Interests:Cell Biology; Exocytosis; Endocytosis; Membrane Traffic; Tethering; Microscopy; Live Cell Imaging; TIRFM; Single molecule

              • Office:(203) 785-4319
              • Lab:(203) 785-5057

              Turk, Benjamin E

              Research Interests:Cell signaling; Protein kinases; Chemical biology; Proteomics; Metalloproteases; Protein engineering

              • Office:(203) 737-2494
              • Lab:(203) 785-3259

              Wajapeyee, Narendra

              Research Interests:Cancer; Genomics; RNAi; Senescence; DNA methylation; RNAi delivery to cancer cells

                Weiss, Robert Martin

                Research Interests:Smooth muscle pharmacology; Signal transduction; Bladder cancer

                • Appt:(203) 785-2815

                Williams, Kenneth R

                Research Interests:protein profiling; phosphoproteomics; protein posttranslational modification

                  Wu, Dianqing (Dan)

                  Research Interests:Wnt; signal transduction; G protein, Chemotaxis;Cell migration; Cancer biology and therapeutics; Stem cell biology; Chemoattractant signaling; Inflammation

                  • Office:(203) 785-3149
                  • Lab:(203) 785-6262

                  Wysolmerski, John Joseph

                  Research Interests:Parathyroid hormone-related protein; Calcium sensing receptor; Breast development; Lactation; Osteoporosis; Bone metastases

                  • Appt:(203) 737-1932

                  Yang, Xiaoyong

                  Research Interests:Nutrient Sensing; Cell Signaling; Circadian Rhythms; Post-translational Modifications; Metabolic Physiology; Diabetes; Cancer; Aging; Systems Biology