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Program Members

Co-Leaders

Petrylak, Daniel P.

Clinical Interests: genitourinary cancer; prostate cancer; clinical trials for men with prostate and bladder cancer.

  • Office: (203) 737-8076
  • Appt: (203) 200-4822

Stern, David F.

  • Office: (203) 785-4832
     

Members

Bennett, Anton M.

Research Interests: Signal transduction; Protein tyrosine phosphatases; Cancer; Diabetes; Obesity; Muscle stem cells; Muscular dystrophy

  • Office: (203) 737-2441
  • Lab: (203) 785-4395

Boggon, Titus

Research Interests: Structural biology of signal transduction

  • Office: (203) 785-2943
  • Lab: (203) 785-7274

Calderwood, David A.

Research Interests: Integrin; Cell adhesion; Cell migration; Cytoskeleton; Structural biology

  • Office: (203) 737-2311
  • Lab: (203) 785-2871

Cantley, Lloyd Garnet

Research Interests: Nephrology; Acute Kidney Injury; Physiology and integrative medical biology; Epithelial cell migration and morphogenesis; Epithelial cell adhesion; Migration; Branching tubulogenesis

  • Office: (203) 785-4186
  • Lab: (203) 785-7111

Chai, Toby C.

Research Interests: Urinary incontinence; Bladder urothelial biology; Neurourology; Voiding disorders

  • Appt: (203) 785-2815

De Camilli, Pietro

Research Interests: Synapses; MembranteTraffic; Endocytosis; Clathrin; Dynamin; Phosphoinositides; Lipid Metabolism; Lowe Syndrome; Bar Proteins; Neurodegeneration; Membrane Contact Sites

  • Office: (203) 737-4461
  • Lab: (203) 737-4457

DiGiovanna, Michael P

Research Interests: Breast cancer; HER-2/neu/ErbB-2; IGF1 receptor; EGF receptor; Growth factor receptor tyrosine protein kinases in malignancy; Estrogen receptor, Signal transduction, breast cancer clinical trials

  • Office: (203) 785-2360
  • Lab: (203) 785-5365
  • Appt: (203) 200-2328

Geibel, John P

Research Interests: Gastric Acid Secretion; Colonic Fluid Transport; Renal Physiology; Intracellular Ion Activity Measurements; Calcium Sensing Receptor; Diarrheal disease, electrophysiology; CFTR; AMPKinase volume regulation

  • Office: (203) 737-4152
  • Lab: (203) 737-1485

Ghosh, Sourav

  • Office: (203) 737-3416

Greco, Valentina

Research Interests: Organ regeneration in vertebrate systems; Stem cells; Stem cell niche organization; Cancer

    Grutzendler, Jaime

    Research Interests: Neuro-glio-vascular interactions, cerebral blood flow and metabolism blood-brain barrier, two-photon microscopy, myelin imaging, synaptic plasticity, development and pathology of the brain microvasculature, Neuroinflammationin, neurodegenerative diseases and stroke

    • Lab: (203) 737-3514
    • Appt: (203) 737-8859

    Hochstrasser, Mark W

    Research Interests: Adenosinetriphosphatase; Cell Growth Regulation; Chemical Cleavage; Chemical Conjugate; Chimeric Protein; Enzyme Activity; Enzyme Complex; Enzyme Mechanism; Enzyme Structure; Fungal Genetics; Gene Deletion Mutation; Immunoelectron Microscopy; Isozyme; Mass Spectrometry; Mutant; Proteasome; Protein Degradation; Protein Purification; Proteinase; Protooncogene; Saccharomyces Cerevisiae; Transcription Factor; Ubiquitin

      Insogna, Karl L.

      Research Interests: Role of dietary protein in skeletal metabolism; Factors that lead to skeletal disease in adult patients with X-linked hypophosphatemic rickets; Cellular mechanisms of PTH-induced bone resorption and bone anabolism; Effects of CSF1 in mature osteoclasts

      • Office: (203) 737-2871
      • Lab: (203) 737-2871
      • Appt: (203) 737-1058

      Kibbey, Richard Glenn

      Research Interests: Mechanisms of insulin secretion by beta-cells; Pathogenesis of beta-cell exhaustion in Type 2 Diabetes Mellitus; Mitochondria

      • Office: (203) 737-4055
      • Appt: (203) 432-0038

      Kim, Joseph W

      • Appt: (203) 200-4822

      Koleske, Anthony J

      Research Interests: Neuronal morphogenesis and degeneration; Stress; Schizophrenia; Cell migration; Cancer; Metastasis; Adhesion receptors

      • Office: (203) 785-5624
      • Lab: (203) 785-5631

      Krauthammer, Michael Oliver

      Research Interests: Molecular interaction networks, computational analysis, pathway discovery, knowledge representation; Statistical modeling and analysis; Text mining in biology, term identification, information extraction

      • Office: (203) 737-1233

      Lam, TuKiet T

      Research Interests: Proteomics; Protein post-translational modifications (PTM); small molecule identification and quantification; high resolution mass spectrometry; LC MS/MS; FT-ICR

      • Office: (203) 785-5086

      Madri, Joseph Anthony

      Research Interests: Connective tissue disorders; Cell-Matrix and Cell-Cell Interactions; Integrin-Mediated Signaling; Cardio-vascular and neuro-vascular development; Angiogenesis and Vascular Biology; inflammation; T-cell–Endothelial cell interactions

      • Office: (203) 785-2763

      Min, Wang

      Research Interests: Inflammation; Angiogenesis/lymphangiogenesis; Atherosclerosis; Transplant rejection; Tumor microenvironment and metastasis

      • Office: (203) 785-6047

      Morrow, Jon Stanley

      Research Interests: Hemolytic Disease; Degenerative Brain Disease; spectrin; Autopsy Pathology; Renal Pathology; Medical Informatics; Computer Aided Instruction (CAI); Telepathology

      • Office: (203) 785-3624
      • Lab: (203) 785-2771
      • Appt: (203) 785-3624

      Nguyen, Don

      Research Interests: Metastasis; Lung cancer; Cancer genomics; Tumor microenvironment

      • Office: (203) 737-4514

      Petrylak, Daniel P.

      Research Interests: Clinical trials for prostate and bladder cancers

      • Office: (203) 737-8076
      • Appt: (203) 200-4822

      Politi, Katerina

      Research Interests: Cancer biology; Mouse models of lung cancer; Epidermal Growth Factor Receptor; ERBB Receptor family; Targeted therapy

        Rimm, David L

        Research Interests: Quantitative Pathology; Cancer Tissue Biomarkers; Melanoma; Breast Cancer; Cell-cell adhesion in cancer; Translation of molecular techniques to diagnostic cytopathology; General Cytopathology; Immunohistochemistry; thyroid pathology

        • Office: (203) 737-4204

        Schlessinger, Joseph

        Research Interests: Growth factor receptors; Intracellular signaling pathways; Protein kinases; Phosphorylation; SH2, SH3 and other protein modules involved in signal transduction; Drug discovery

        • Office: (203) 785-7395
        • Lab: (203) 785-7382

        Solomon, Mark J

        Research Interests: Cell cycle; Ubiquitin-mediated proteolysis; Anaphase-promoting Complex

        • Office: (203) 436-9053

        Stern, David F.

        Research Interests: Cancer Biology; Signal transduction by HER2/ErbB2 and other EGF family receptor tyrosine kinases; EGF family receptors in breast cancer and mammary development; DNA damage checkpoint signaling; Functional and genetic analysis of cancer; Melanoma

        • Office: (203) 785-4832

        Toomre, Derek K.

        Research Interests: Cell Biology; Exocytosis; Endocytosis; Membrane Traffic; Tethering; Microscopy; Live Cell Imaging; TIRFM; Single molecule

        • Office: (203) 785-4319
        • Lab: (203) 785-5057

        Turk, Benjamin E

        Research Interests: Cell signaling; Protein kinases; Chemical biology; Proteomics; Metalloproteases; Protein engineering

        • Office: (203) 737-2494
        • Lab: (203) 785-3259

        Wajapeyee, Narendra

        Research Interests: Cancer; Genomics; RNAi; Senescence; DNA methylation; RNAi delivery to cancer cells

        • Office: (203) 737-5070

        Weiss, Robert M.

        Research Interests: Smooth muscle pharmacology; Signal transduction; Bladder cancer

        • Appt: (203) 785-2815

        Williams, Kenneth R

        Research Interests: protein profiling; phosphoproteomics; protein posttranslational modification

          Wu, Dianqing (Dan)

          Research Interests: Wnt; signal transduction; G protein, Chemotaxis;Cell migration; Cancer biology and therapeutics; Stem cell biology; Chemoattractant signaling; Inflammation

          • Office: (203) 785-3149
          • Lab: (203) 785-6262

          Wysolmerski, John Joseph

          Research Interests: Parathyroid hormone-related protein; Calcium sensing receptor; Breast development; Lactation; Osteoporosis; Bone metastases

          • Appt: (203) 737-1932

          Yang, Xiaoyong

          Research Interests: Nutrient Sensing; Cell Signaling; Circadian Rhythm; Post-translational Modifications; Metabolic Physiology; Diabetes; Cancer; Aging; Systems Biology