Nancy Hartman Ruddle, PhD

Professor Emeritus of and Senior Research Scientist in Epidemiology (Microbial Diseases)

Departments & Organizations

Cancer Immunology

Diabetes Research Center


Immunology and Immunotherapy

Lymphocyte Development

NIH T32 Program

School of Public Health: Parasitology Program | Vaccine Group

Tissue Specific Stem Cells

Vascular Biology and Therapeutics Program

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Immunology: Consequences of an Immune Response; Lymphocyte Development; Regulating the Immune Response | Microbiology: Immunology & Host Response


Nancy Ruddle is known for her discovery and analysis of lymphotoxin, a protein produced by T cells that plays a role in the protective immune system and destroys tumor cells. She and researchers in her laboratory have engaged in research on the lymphotoxin/tumor necrosis factor family, their regulation and roles in lymphoid organ development and pathogenesis of viral and autoimmune disease. The more than 170 scientific articles Ruddle has authored or co-authored have explored the immunology of such diseases as leukemia, experimental allergic encephalomyelitis and Leishmania amazonensis infection, among others. She continues to generate insight into the regulation and function of lymphoid organs through her analysis of the vessels crucial for their function.

Education & Training

PhD Yale University (1968)

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Contact Info

Nancy Hartman Ruddle, PhD
Office Location
Amistad Street Building
10 Amistad Street, Ste 131h

New Haven, CT 06519
Mailing Address
Yale School of Public HealthPO Box 208034
60 College Street

New Haven, CT 06520-8034