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Developmental Therapeutics

Program Members

Co-Leaders

Anderson, Karen S

  • Office:(203) 785-4526
  • Lab:(203) 737-1527

Burtness, Barbara

Clinical Interests:head and neck cancers; esophagogastric cancers; non-melanoma skin cancer; thyroid cancer;

  • Office:(203) 737-7636
  • Appt:(203) 200-4622

Members

Abu-Khalaf, Maysa

Research Interests:Clinical trials evaluating novel agents for the treatment of breast; Ovarian and endometrial cancers; PI3K-mTOR inhibitors; HER-2 targeted therapies; Angiogenesis

  • Office:(203) 737-8309
  • Appt:(203) 200-2328

Anderson, Karen S

Research Interests:Enzyme function; Anti-viral agents

  • Office:(203) 785-4526
  • Lab:(203) 737-1527

Azodi, Masoud

Research Interests:Translational research; Clinical research; Gynecologic cancer

  • Office:(203) 785-4013
  • Appt:(203) 200-4176

Baehring, Joachim M

Research Interests:Molecular markers of cancer; Nervous system lymphoma

  • Appt:(203) 785-7284

Brandt, Debra Schwab

Research Interests:Clinical Protocol Investigator: Phase II trial of cytoxan, vincristine, and fludarabine in patients with CLL and primary and refractory low grade non-hodgkin’s lymphoma.

    Breaker, Ronald R

    Research Interests:non-coding RNA; riboswitches; ribozymes; catalytic DNA; RNA and evolution; antibiotics development

    • Office:(203) 432-9389
    • Lab:(203) 432-6554

    Burtness, Barbara

    Research Interests:EGFR expressed head and neck cancers.

    • Office:(203) 737-7636
    • Appt:(203) 200-4622

    Cha, Charles H

    Research Interests:Development of robotic and laparoscopic approaches for benign and malignant conditions of the liver, pancreas and stomach; Effects of angiogenesis on gastrointestinal malignancy; Gene silencing techniques to knockdown proliferation of hepatocellular carcinoma in vitro and in vivo; Diagnostic and therapeutic utility of angiogenic inhibitors for treatment of solid tumors; Clinical outcomes in surgery for sarcoma, hepatobiliary, gastric and esophageal malignancy

    • Appt:(203) 785-2380

    Chao, Herta H

    Research Interests:Prostate cancer; Androgen deprivation therapy; Cognitive function; Lung cancer; Phospho-inositol-3 kinase pathway as a drug target

      Cheng, Yung-Chi

      Research Interests:Cancer; Viral chemotherapy; Chinese herbs; Chinese medicine

      • Office:(203) 785-7118
      • Lab:(203) 785-7119

      Choi, Jennifer Nam

      Research Interests:Cutaneous side effects of chemotherapy and radiation; Melanoma treatment

      • Office:(203) 785-4092
      • Appt:(203) 789-1249

      Chung, Gina G

      • Office:(203) 785-2876
      • Appt:(203) 200-2328

      Crawford, Jason Michael

      Research Interests:Small molecule signaling; Antibiotic discovery & biosynthesis; Host-bacteria interactions; Bacterial secondary metabolism; Bacteria; Pathogen

        Crews, Craig M

        Research Interests:Limb regeneration; wound epidermis; blastema; natural product mode of action studies; angiogenesis; Wnt signaling; protein turnover; protein kinase regulation

        • Office:(203) 432-9364
        • Lab:(203) 432-6553

        De Feyter, Henk

        Research Interests:In vivo 13C MRS, Brain metabolism, tumor metabolism

          Deshpande, Hari Anant

          Research Interests:Clinical trials in head and neck cancer; Sarcoma; Genitourinary (GU) cancer; Thyroid cancer; Endocrine cancers

          • Office:(203) 737-1600
          • Appt:(203) 200-4822

          DeVita, Vincent T, Jr

          Research Interests:Drug Resistance; Hodgkin's Disease; Lymphomas; Molecular Technology.

          • Office:(203) 737-1010

          Eder, Joseph Paul

          Research Interests:Phase I clinical trials; Cancer pharmacology; Angiogenesis

          • Office:(203) 737-6980
          • Appt:(203) 200-4422

          Ehrlich, Barbara E

          Research Interests:Intracellular calcium regulation

          • Office:(203) 737-1158
          • Lab:(203) 737-1158

          Ellman, Jonathan A

          Research Interests:proteases, phosphatases, inhibitors, C-H functionalization, asymmetric amine synthesis

            Engelman, Donald Max

            Research Interests:Helix Interactions; Lipid Bilayers; Membranes; Physical Biochemistry; Protein Folding; Proteins

              Farrell, James J

              Research Interests:Pancreatic Cancer Early Diagnosis; Pancreatic Cystic Neoplasms, Pancreatic Biomarkers, Personalized Medicine, Pancreatic Disease, Gastrointestinal Oncoloy

              • Office:(203) 785-6228
              • Lab:(203) 200-5083
              • Appt:(203) 200-5083

              Gettinger, Scott Nicholas

              Research Interests:Clinical trial design; Novel therapeutics; Radiosensitizers; Prognostic biomarkers

              • Appt:(203) 200-5864

              Goldberg, Sarah B

              Research Interests:Clinical trials; Translational research; Novel therapeutics; Personalized medicine

              • Office:(203) 785-7564
              • Appt:(203) 200-5864

              Gore, Steven D.

              Research Interests:Clinical trials for patients with leukemia and meylodysplastic syndromes with a focus on translational research. Mechanism behind the clinical activity of drugs which putatively target epigenetic dysregulation.

              • Office:(203) 737-7103
              • Appt:(203) 200-4363

              Ha, Ya

              Research Interests:Membrane protein; X-ray crystallography; Enzyme mechanism

              • Office:(203) 785-7530
              • Lab:(203) 785-7360

              Herbst, Roy S.

              Research Interests:Early phase clinical trials; Biomarker studies; Personalized medicine for cancer treatment.

              • Office:(203) 785-6879
              • Appt:(203) 200-5864

              Hochster, Howard S

              Research Interests:Clinical research; Pharmacology; Anti cancer drug development; Early clinical trials in cancer

              • Appt:(203) 200-4422

              Hodsdon, Michael Edwin

              Research Interests:Biochemistry; Biophysics; Breast Cancer; Clinical Chemistry; Drug Metabolism; Health and Medicine; Laboratory Practice or Procedure; Nuclear Magnetic Resonance; Pathobiology; Pharmacology; Spectroscopy; Structural Biology; Toxicology

              • Office:(203) 688-2622
              • Lab:(203) 737-2684
              • Appt:(203) 688-2445

              Horowitz, Nina Ruth

              • Appt:(203) 200-2328

              Jordt, Sven-Eric

              Research Interests:Pain; Touch; Pruritus; Chemical Sensing; Sensory Neurons; TRP Ion Channels; Environmental exposures; Neural sensitization in asthma; Hypersensitivity disorders; Dermatitis; Smoking; Menthol; Electronic cigarettes; Tear Gas

              • Office:(919) 684-1327
              • Lab:(919) 684-1319

              Kenney, Patrick A.

              Research Interests:Investigator-initiated and cooperative group trials; Integration of surgery and novel systemic therapies; Renal Cell Carcinoma

              • Appt:(203) 785-2815

              Kluger, Harriet

              Research Interests:Prognostic and predictive markers in melanoma and renal cell carcinoma; Development of new drugs for melanoma and renal cell carcinoma

              • Appt:(203) 200-6622

              Koo, Jaseok Peter

              Research Interests:Cancer prevention and therapy; Lung carcinogenesis; Epithelial cell biology; Personalized medicine; Molecular targets; Drug development; Transcription Factor CREB; Inflammation; Cytokines and chemokines and receptors; Biomarkers for early detection and therapy

                Lacy, Jill

                Research Interests:Clinical research in gastrointestinal malignancies; Gastroesphageal, pancreatic, and colorectal cancers; Brain tumors; Epstein-Barr virus-associated malignancies

                • Appt:(203) 200-4422

                Lilenbaum, Rogerio C.

                Research Interests:Lung cancer; Treatment of lung cancer; Elderly patients with lung cancer

                • Office:(203) 200-2094
                • Appt:(203) 200-5864

                Lindskog, Dieter M.

                Research Interests:Bone graft alternatives; Metastatic disease

                • Office:(203) 785-2579
                • Appt:(203) 737-5656

                Lolis, Elias

                Research Interests:Cancer; Inflammation; Infectious disease; Macromolecular X-ray crystallography; Signaling pathways; Drug design; High throughput screening (HTPS)

                • Office:(203) 785-6233
                • Lab:(203) 737-1526

                LoRusso, Patricia

                Research Interests:early phase drug development

                  Lynch, Thomas James

                  Research Interests:Lung cancer; EGFR; Targeted therapy; Personalized medicine

                  • Appt:(203) 200-5864

                  Michaud, Gaetane Celine

                  Research Interests:Complex Airway Disorders; Pleural Disease; Lung Cancer; COPD/Emphysema; Decision Support; Lung Cancer Screening

                  • Office:(203) 737-5699
                  • Appt:(203) 737-5699

                  Moliterno, Jennifer

                  Research Interests:Clinical trials for brain tumors; Personalized medicine for patients with brain tumors; Brain tumors

                    Mor, Gil G

                    Research Interests:Immunology of Gynecologic tumors; Immunology of Implantation; Ovarian Cancer Stem Cells

                    • Office:(203) 785-6294
                    • Lab:(203) 737-1405

                    Neparidze, Natalia

                    Research Interests:Hematologic malignancies Multiple Myeloma Myelodysplastic syndromes Acute myeloid leukemia

                      Parker, Terri Lynn

                      • Appt:(203) 200-4363

                      Patrizio, Pasquale

                      Research Interests:Fertility and Infertility; Cryopreservation; Oocyte biology; Embryonic competence

                      • Office:(203) 764-5866
                      • Appt:(203) 785-4708

                      Peduzzi, Peter Natale

                      Research Interests:Clinical trials; Comparative effectiveness research; General statistical methods; Variable selection

                      • Office:(203) 785-5615

                      Piepmeier, Joseph Massa

                      Research Interests:Neuro-oncology; Acoustic neuroma; General neurosurgery; Brain and spinal cord cancer; Brachytherapy; Stereotactic needle biopsy

                      • Appt:(203) 785-2791

                      Regan, Lynne J

                      Research Interests:Mental retardation; Protein-protein interactions; Fragile X Mental Retardation Protein (FMRP); Protein-based nanomaterials

                        Roberts, John D

                        Research Interests:Sickle cell disease; Phase I clinical trials in oncology; Prostate cancer; Bladder cancer; Testicular cancer; Clinical trials design.

                          Rose, Michal Gillian

                          • Office:(203) 937-3421

                          Rutherford, Thomas J.

                          Research Interests:Minimally invasive surgical techniques; Ovarian stem cell research; Micro-RNA; Novel biologic agents for treatment; Early detection of ovarian cancer

                          • Office:(203) 785-6301
                          • Appt:(203) 200-4176

                          Saltzman, W. Mark

                          Research Interests:Bio-compatible polymers, drug delivery systems

                          • Office:(203) 432-4262

                          Sartorelli, Alan Clayton

                          Research Interests:Cancer research; Drug development; Drug resistance

                          • Office:(203) 785-4533
                          • Lab:(203) 785-4534

                          Sasaki, Clarence Takashi

                          Research Interests:Laryngeal physiology; Head and neck cancer

                          • Appt:(203) 200-4622

                          Schepartz, Alanna

                          Research Interests:Organic chemistry; chemical biology; biosynthetic engineering; drug design; synthetic biology; Novel methods to inhibit HIV infection

                          • Office:(203) 432-5094

                          Sessa, William C.

                          Research Interests:Vascular endothelium and inflammation; MiRNAs; Vascular development and angiogenesis; Lipid domains and signaling; Atherosclerosis

                          • Office:(203) 737-2291

                          Shuch, Brian M.

                          Research Interests:Translational research; Systemic therapy clinical trials; Development of predictive/prognostic biomarkers; Genetic characterization of kidney cancer; Hereditary cancer predisposition

                          • Appt:(203) 785-2815

                          Spiegel, David Adam

                          Research Interests:Design of novel molecules that enhance the recognition of various pathogens, including viruses, by the human immune system

                          • Office:(203) 432-8697

                          Sprenkle, Preston C.

                          Research Interests:Multiparametric MRI; Fusion prostate biopsy; Prostate cancer active surveillance; Nanoparticles; Novel diagnostics for prostate cancer; Focal ablation of cancer; Cryoablation; Irreversible electroporation

                          • Appt:(203) 785-2815

                          Stein, Stacey M

                          • Appt:(203) 200-4422

                          Takyar, Shervin (Seyedtaghi)

                          Research Interests:Non-coding RNAs; Endothelial Responses; Th2 Immunity; Lung Injury; Tumor Microenvironment; Macrophage Activation

                            Vasiliou, Vasilis

                            Research Interests:Mechanisms of Cellular Responses to Environmental Stress, Gene-Environment Interactions; Alcohol and Disease; Aldehyde Dehydrogenases and Glutathione in Metabolism and Disease (specifically, diabetes, gout and cancer), Cancer Drug Discovery, and Evolution of Gene Families.

                            • Office:(203) 737-8094

                            Zhou, Jiangbing

                            Research Interests:Nanomedicine; Brain cancer; Stroke, Traumatic brain injury Neurodegenerative disorders; Drug delivery; Gene therapy; Stem cell therapy;

                            • Office:(203) 785-5327