Anthony J Koleske, PhD

Professor of Molecular Biophysics and Biochemistry

Departments & Organizations

Cancer Center, Yale: Signal Transduction

Interdepartmental Neuroscience Program

Kavli Institute for Neuroscience

Molecular Biophysics and Biochemistry: Neurobiology

Office of Student Research

Signal Transduction

WHRY Pilot Project Program Investigators

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Biochemistry, Biophysics and Structural Biology: Neurobiology | Molecular Cell Biology, Genetics and Development: Developmental Biology; Receptors and Signal Transduction | Neuroscience: Development; Molecular/Cellular Neuroscience | Principal Investigator


Anthony J. Koleske is an expert in understanding the biochemical mechanisms that control changes in cell shape and movement. After receiving a B.S. in Biochemistry and Molecular Biology at the University of Wisconsin-Madison, Dr. Koleske performed his Ph.D. studies with Dr. Richard Young at the Whitehead Institute/Massachusetts Institute of Technology.For his Ph.D. thesis, Dr. Koleske discovered the RNA polymerase II holoenzyme, an important advancement in understanding how gene transcription is turned on.Dr. Koleske went on to do a postdoctoral fellowship with Nobel Laureate Dr. David Baltimore at M.I.T., where he began his work studying cellular functions of Abl family kinases, which his laboratory has shown are essential regulators of the cytoskeleton in diverse cell types.Dr. Koleske joined the Department of Molecular Biophysics and Biochemistry at Yale University in 1998, where he currently is Professor and holds a joint appointment in the Department of Neurobiology.Dr. Koleske is the recipient of numerous awards including a Jane Coffin Childs Postdoctoral Fellowship, Special Fellowship and Scholar Awards from the Leukemia and Lymphoma Society, a NARSAD Young Investigator Award, and an Established Investigator Award from the American Heart Association.He has served widely on review panels, including terms as Chair of the Basic Science Study Section for the American Heart Association and the Neurodifferentiation, Plasticity, Repair, and Rhythmicity Study Section of the NIH.He currently directs the combined Ph.D. programs in the Biological and Biomedical ScienceS at Yale, the China Scholarship Council-Yale World Scholars Program, and co-directs (with Mike Nitabach) the Medical Research Scholars Program at Yale. He is married to Ruth Koleske and is father to twins Ben and Emily.

Education & Training

PhD Massachusetts Institute of Technology (1993)
BS University of Wisconsin (1988)

Honors & Recognition

  • Established Investigator American Heart Association (2007)

  • Young Investigator AwardNational Alliance for Research on Schizophrenia and Depression (2002)

  • Scholar AwardLeukemia and Lymphoma Society (2002)

  • Hellman Family Fellow (2001)

  • Special FellowLeukemia and Lymphoma Society (1997)

  • FellowJane Coffin Childs Foundation for Cancer Research (1994)

Professional Service

  • NDPR Study Section NIH (2009 - 2013)

  • Yale Stockroom Committee (2008)

  • Yale Safety Committee (2008)

  • Leslie C. Warner Postdoctoral Fellowship Selection Committee (2008)

  • Member of American Heart Association Basic Science Study Section (2007-2010) Co-Chair of American Heart Association Basic Science Study Section (2008) American Heart Association Basic Science Study Section (2007-present) American Heart Association (2007 - 2011)

  • MB&B Retreat Organizer (2007 - 2008)

  • Yale Graduate Recruiter at ABRCMS (2007)

  • Yale Scholar Awards Committee (2004 - 2008)

  • MB&B Mentoring Policy Committee (Chair) (2004)

  • Freshman Advisor Morse College (2003 - 2004)

  • MB&B Director of Medical Students (2001 - 2001)

  • Yale Cancer Center Pilot Grant Selection Committee (2001)

  • Organizer CMB student RIP talks (2000 - 2001)

  • MB&B Graduate Admissions Committee (2000 - 2001)

  • Writing Workshop for Graduate students (2000)

  • MB&B Graduate Education Committee (1999 - 2008)

  • MB&B Undergraduate Education Committee MB&B Undergraduate Education Committee (1999 - 2002)

  • Faculty Advisor to MB&B Undergraduate Students (1999 - 2002)

  • Cell Mol Biol Training Grant Executive Committee (1999)

  • Yale CNNR Search Committee

  • MB&B Search Committees (2001, 2007, 2008)

  • Reviewer for: Brain Research, Current Biology, Development, Developmental Cell, Journal of Biological Chemistry

  • Ad hoc grant reviewer for the Human Frontier Science Program, Louisiana Board of Regents, the March of Dimes, National Science Foundation, the Medical Research Council (UK), and the Telethon Competition (Italy). Louisiana Board of Regents, the March of Dimes, National Science Foundation, the Medical Research Council (UK), and the Telethon Competition (Italy).

  • Journal of Cell Biology, Journal of Cell Science, Journal of Neurochemistry, Journal of Neuroscience, Molecular and Cellular Neuroscience

  • Reviewer for: Molecular Biology of the Cell, Molecular and Cellular Biology, Nature Cell Biology, Oncogene, and PLoS Biology, PNAS

  • Yale McDougal Center Workshop “Applying and Interviewing for a Faculty Position” 2008, 2009

  • Director of Graduate Admissions MB&B (2003-2005, 2009-present)

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Contact Info

Anthony J Koleske, PhD
Mailing Address
MB and BPO Box 208024
333 Cedar Street

New Haven, CT 06520-8024