Signal Transduction

Program Members

Co-Leaders

Daniel Petrylak

Professor
Co-Director, Signal Transduction Research Program

Clinical Interests:genitourinary cancer; prostate cancer; clinical trials for men with prostate and bladder cancer.

Office:(203) 737-8076
Appt:(203) 200-4822

David Stern

Professor of Pathology
Associate Director, Shared Resources, Yale Cancer Center
Leader, Signal Transduction Research Program, Yale Cancer Center

Office:(203) 785-4832
Lab:(203) 785-6496

Members

Anton Bennett

Associate Professor of Pharmacology and of Comparative Medicine
Co-Director, Program in Integrative Cell Signaling and Neurobiology of Metabolism
Director, BBS Minority Affairs

Research Interests:Signal transduction; Protein tyrosine phosphatases; Cancer; Diabetes; Obesity; Muscle stem cells; Muscular dystrophy

Office:(203) 737-2441
Lab:(203) 785-4395

Titus Boggon

Associate Professor of Pharmacology

Research Interests:Structural biology of signal transduction

Office:(203) 785-2943
Lab:(203) 785-7274

David Calderwood

Associate Professor of Pharmacology and of Cell Biology

Research Interests:Integrin; Cell adhesion; Cell migration; Cytoskeleton; Structural biology

Office:(203) 737-2311
Lab:(203) 785-2871

Lloyd Cantley

C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular and Molecular Physiology
Associate Chair, Research

Research Interests:Nephrology; physiology and integrative medical biology; epithelial cell migration and morphogenesis; epithelial cell adhesion; migration; branching tubulogenesis

Office:(203) 785-4186
Lab:(203) 785-7111

Pietro De Camilli

Eugene Higgins Professor of Cell Biology and Professor of Neurobiology
Director, Yale Program in Cellular Neuroscience and Neurodegeneration and Repair
Investigator, Howard Hughes Medical Institute

Research Interests:Synapses; exocytosis; endocytosis; membranes; clathrin; dynamin; phosphoinositides; Lowe syndrome; BAR proteins; neurodegeneration

Office:(203) 737-4461
Lab:(203) 737-4457

Michael DiGiovanna

Associate Professor of Medicine (Medical Oncology) and of Pharmacology

Research Interests:Breast cancer; HER-2/neu/ErbB-2; IGF1 receptor; EGF receptor; Growth factor receptor tyrosine protein kinases in malignancy; estrogen receptor, signal transduction

Office:(203) 785-2360
Lab:(203) 785-5365
Appt:(203) 200-2328

Rong Fan

Assistant Professor of Biomedical Engineering

John Geibel

Professor of Surgery (Gastrointestinal) and of Cellular and Molecular Physiology
Vice Chair, Surgery
Director, Surgical Research

Research Interests:Gastric Acid Secretion; Colonic Fluid Transport; Renal Physiology; Intracellular Ion Activity Measurements; Calcium Sensing Receptor; Diarrheal disease, electrophysiology; CFTR; AMPKinase volume regulation

Office:(203) 737-4152
Lab:(203) 737-1485

Valentina Greco

Assistant Professor of Genetics and of Dermatology

Research Interests:Organ regeneration in vertebrate systems; Stem cells; Stem cell niche organization; cancer

Jaime Grutzendler

Associate Professor of Neurology and of Neurobiology
Director, Yale Center for Experimental Neuroimaging (YCEN)

Research Interests:Two-photon microscopy; Neurodegeneration; Alzheimer's; Blood-brain barrier; Microvasculature; Synapses; Neuroinflammation; Microglia; Astrocyte; Endothelium, myelin imaging

Office:(203) 737-2765
Lab:(203) 737-3514

Mark Hochstrasser

Eugene Higgins Professor of Molecular Biophysics and Biochemistry and Professor of Molecular, Cellular, and Developmental Biology

Research Interests:Adenosinetriphosphatase; Cell Growth Regulation; Chemical Cleavage; Chemical Conjugate; Chimeric Protein; Enzyme Activity; Enzyme Complex; Enzyme Mechanism; Enzyme Structure; Fungal Genetics; Gene Deletion Mutation; Immunoelectron Microscopy; Isozyme; Mass Spectrometry; Mutant; Proteasome; Protein Degradation; Protein Purification; Proteinase; Protooncogene; Saccharomyces Cerevisiae; Transcription Factor; Ubiquitin

Valerie Horsley

Assistant Professor of Molecular, Cellular, and Developmental Biology and of Dermatology

Karl Insogna

Professor of Medicine (Endocrinology)
Director, Yale Bone Center

Research Interests:Role of dietary protein in skeletal metabolism; Factors that lead to skeletal disease in adult patients with X-linked hypophosphatemic rickets; Cellular mechanisms of PTH-induced bone resorption and bone anabolism; Effects of CSF1 in mature osteoclasts

Office:(203) 737-2871
Lab:(203) 737-2871
Appt:(203) 737-1058

Hakryul Jo

Associate Research Scientist in Epidemiology (Environmental Health)

Research Interests:Natural and synthetic chemicals; Cancer; Age-related macular degeneration

Richard Kibbey

Assistant Professor of Medicine (Endocrinology) and of Cellular and Molecular Physiology

Research Interests:Mechanisms of insulin secretion by beta-cells; pathogenesis of beta-cell exhaustion in Type 2 Diabetes Mellitus; mitochondria

Office:(203) 737-4055
Appt:(203) 432-0038

Anthony Koleske

Professor of Molecular Biophysics and Biochemistry and of Neurobiology

Research Interests:Neuronal morphogenesis and degeneration; stress; schizophrenia; cell migration; cancer; metastasis; adhesion receptors

Office:(203) 785-5624
Lab:(203) 785-5631

Michael Krauthammer

Associate Professor of Pathology

Research Interests:Molecular interaction networks: computational analysis, pathway discovery, knowledge representation; Statistical modeling and analysis; Text mining in biology: term identification, information extraction

Joseph Madri

Professor of Pathology
Director of Education

Research Interests:Connective tissue disorders; Cell-Matrix and Cell-Cell Interactions; Integrin-Mediated Signaling; Cardio-vascular development; Angiogenesis and Vascular Biology; inflammation; T-cell-Endothelial cell interactions

Office:(203) 785-2763
Appt:(203) 785-2783

Nita Maihle

Professor of Obstetrics, Gynecology, and Reproductive Sciences, of Pathology and of Pharmacology
Director, Biology of Reproductive Tract Cancers Program

Research Interests:Cancer; Women's cancers; Diagnostics; Theragnostics; Biotherapeutics; Precision/personalized medicine, signal transduction; EGFR/ERBB/HER-driven adult solid tumors

Office:(203) 785-5212
Lab:(203) 737-1385

Wang Min

Associate Professor of Pathology

Research Interests:Inflammation; Angiogenesis; Atherosclerosis; Transplant rejection; Tumor metastasis

Jon Morrow

Raymond Yesner Professor of Pathology
Chair, Department of Pathology
Chief of Pathology at YNHH

Research Interests:Hemolytic Disease; Degenerative Brain Disease; spectrin; Autopsy Pathology; Renal Pathology; Medical Informatics; Computer Aided Instruction (CAI); Telepathology

Office:(203) 785-3624
Lab:(203) 785-2771
Appt:(203) 785-3624

Don Nguyen

Assistant Professor of Pathology

Research Interests:Metastasis; Lung cancer; Cancer genomics; Tumor microenvironment

Office:(203) 737-4514

Katerina Politi

Assistant Professor of Medicine (Medical Oncology) and of Pathology

Research Interests:Cancer biology; Mouse models of lung cancer; Epidermal Growth Factor Receptor; ERBB Receptor family; Targeted therapy

David Rimm

Professor of Pathology
Director of Pathology Tissue Services
Director of Translational Pathology

Research Interests:Quantitative Pathology; Cancer Tissue Biomarkers; Melanoma; Breast Cancer; Cell-cell adhesion in cancer; Translation of molecular techniques to diagnostic cytopathology; General Cytopathology; Immunohistochemistry; thyroid pathology

Office:(203) 737-4204
Appt:(203) 737-4204

Joseph Schlessinger

William H. Prusoff Professor of Pharmacology
Chair, Pharmacology
Director, Cancer Biology Institute

Research Interests:Growth factor receptors; Intracellular signaling pathways;protein kinases; phosphorylation; SH2, SH3 and other protein modules involved in signal transduction; drug discovery