Preston C. Sprenkle, MD

Associate Professor of Urology; Division Chief, Division of Urology at VA Connecticut Healthcare System; Director, Urology Research Fellowship; Director, Urologic Oncology Clinical Fellowship Program

Departments & Organizations

Urology: Robotic Surgery and Laparoscopy | Urologic Oncology

Yale Cancer Center: Developmental Therapeutics | Prostate & Urologic Cancers Program | Smilow Screening & Prevention Program

Yale Medicine

General Adult Urology


Dr. Preston C. Sprenkle specializes in the treatment of urologic cancers, including prostate cancer, kidney cancer, bladder cancer, testicular cancer and sarcoma – a rare kind of cancer that grows in cells that connect or support other parts of the body, like bone or muscle.

Dr. Sprenkle has dedicated his career to using the latest imaging technologies to improve diagnosis. He was one of the first physicians nationwide to implement the use of the Artemis Device. This machine, introduced in 2009, allows a surgeon to use 3D ultrasound technology and merge it with even more precise magnetic resonance imaging (MRI) to accurately identify cancerous tumors.

“Skilled and experienced radiologists are rare for this relatively new technique,” Dr. Sprenkle explains. “At Yale, we are fortunate to have some of the world leaders in prostate MRI.”

Dr. Sprenkle is also a pioneer in “focal therapy,” which allows a surgeon to treat tiny prostate lesions, rather than the whole organ. This avoids many of the side effects—such as erectile dysfunction and incontinence—that may follow the removal of the whole prostate.

“Exciting technological advances are revolutionizing urology. Prostate cancer is very common and current treatments can majorly impact a man's sexual and urinary function,” Dr. Sprenkle says. “Developing ways to minimize the impact of prostate cancer diagnosis and treatment on a man's health and quality of life is tremendously rewarding.”

Dr. Sprenkle believes in working with patients to come up with individualized treatment plans. “I want my patients to feel that I hear their concerns and treat them like a person. I am pleased at the end of a long consultation when they feel like they understand their disease and their options.”

Education & Training

MD Columbia University (2004)
BA Stanford University, Human Biology (1998)
Fellowship Memorial Sloan Kettering Cancer Center
Residency New York Presbyterian Hospital
Internship New York Presbyterian Hospital
Board Certification AB of Urology, Urology (2014)

Honors & Recognition

  • Best Poster Podium PresentationYoung Urologic Oncologist dinner, Society Of Urologic Oncology Annual Meeting (2009)

  • Finalist - NY section AUA Valentine Essay ContestNY Academy of Medicine (2009)

  • Finalist - NY section AUA Valentine Essay ContestNY Academy of Medicine (2007)

  • First Prize - NY section AUA Valentine Essay ContestNY Academy of Medicine (2006)

  • Arnold P. Gold Humanism in Medicine Honors Society (2004)

  • Alpha Omega Alpha Medical School Honors Society (2004)

  • Outstanding Member of Stanford CommunityStanford University (1998)

  • Member, Board of DirectorsStanford University Alumni Association (1997)

Professional Service

  • NCCN Prostate Cancer Early Detection Panel (2014)

  • "Journal of Urology" (2009 - 2015) Reviewer

  • "Frontiers in Science" (2009 - 2015) Reviewer

  • "Urology" (2009 - 2015) Reviewer

  • Washington Heights free prostate cancer education and screening clinic (2008) Participant


  • Grand Round Presentation "Management of T1 Bladder Cancer" Brooklyn, United States (2011 - 2011)

  • Annual Meeting, Society of Urologic Oncology "B7x is a seum marker for prostate cancer." Bethseda, United States (2009 - 2009)

  • Annual Meeting, American Urological Association, "The bladder trigone is not a Wolffian duct remnant." San Francisco, United States (2006 - 2006)

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Contact Info

Preston C. Sprenkle, MD
Patient Care Locations
Yale UrologyVA Connecticut Healthcare
950 Campbell Avenue

West Haven, CT 06516
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Yale UrologyYale Physicians Building
800 Howard Avenue, Ste 3rd Floor

New Haven, CT 06519
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Mailing Address
UrologyPO Box 208058
New Haven, CT 06520-8058

Curriculum Vitae