On June 17, 2022, the Yale Head and Neck SPORE held their annual Career Enhancement and Developmental Research (CEP and DRP) Symposium at West Campus. More than 65 head and neck investigators across three participating institutions; Yale University, Fox Chase Cancer Center/Temple University, and University of North Carolina (UNC) joined in-person and via Zoom. The CEP and DRP are designed to recruit and promote investigators in head and neck cancer research. The first two cycles of awardees, six DRP and eight CEPs, presented their projects and discussed their future plans with a very dynamic and engaged audience. Barbara Burtness, MD, principal investigator of the YHN SPORE commented, “We were thrilled by the range of projects and the pace of progress reflected in the talks presented at this symposium. Our pilot funds are pulling together a wonderful group of scientists who are advancing our knowledge of head and neck cancer biology and treatment.” Kathryn Ferguson, PhD, Director of the CEP program said, “It was great to see how integrated these awardees have already become in the Head and Neck SPORE team, and to hear ideas for future collaborations”. The new recipients for the 2022-2023 CEP and DRP were announced at end of the Symposium.