Evolution of the Lynch Syndrome
December 09, 2020Evolution of the Lynch Syndrome
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- 00:00So it really has evolved
- 00:02tremendously from 10 years ago or so.
- 00:05We're having a lynching and diagnosis,
- 00:07and the particular gene that was
- 00:09causing it made little difference to us,
- 00:12and we all thought that that they
- 00:14all had a very high risk of cancer.
- 00:17Under four, they really at,
- 00:19we counseled in a very similar way too.
- 00:22Now that we've learned so much more
- 00:25about the specific risks by gene that
- 00:28actually we are starting to propose not.
- 00:30So no longer talk about Lynch
- 00:33syndrome in general,
- 00:34but seeing MLH 1 Lynch syndrome and
- 00:36message to Lynch intimacy because
- 00:38the what it means having one mutation
- 00:41versus another is very different,
- 00:43and that's what we're trying
- 00:45to tell our patients,
- 00:47and that's why little by little
- 00:49we're tailoring more surveillance
- 00:50and recommendations to the
- 00:52run specific mutations.
- 00:53That is really more of a
- 00:55personalized approach.
- 00:56And as we learn more,
- 00:58we're really developing these these.
- 01:00Uh, Survaillance recommendations more
- 01:02tailored to those specific genes,
- 01:04and we'll hear more.
- 01:05And as we learn more about
- 01:07modifiers and other things,
- 01:09probably will be be able to narrow
- 01:12the choices for every single person,
- 01:14even more.
- 01:15So again,
- 01:16what we were saying several years ago
- 01:18based on the knowledge at that time,
- 01:21mass has changed quite a
- 01:23bit now, and I'm very sure
- 01:25than a few years it's going to be
- 01:28very different from all we're saying.
- 01:31Today, so I think that emphasizes the
- 01:33importance of keeping in touch with
- 01:35cancer genetics programs for patients,
- 01:37because what we told them,
- 01:39what they may change.
- 01:40It's extremely likely it's
- 01:42going to change in the future,
- 01:44and so they can benefit from
- 01:46more updated information.