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INFORMATION FOR

September 1, 2021: A Smilow Patient and Family Forum

September 02, 2021
  • 00:00Welcome to the Smilow
  • 00:02patient and Family Forum.
  • 00:04It's my pleasure to welcome you back.
  • 00:06For those of you who may have been
  • 00:08here the last time we were together.
  • 00:10But for those of you joining or the
  • 00:12first time my name is Doctor Nita
  • 00:14Uja I'm the interim director for the
  • 00:16Yale Cancer Center and position in
  • 00:18Chief for the Smilow Cancer Hospitals.
  • 00:20My other job is the chair of the
  • 00:22Department of Surgery and it's
  • 00:24a pleasure to see all of you,
  • 00:26or at least have you join us this evening.
  • 00:29So with that? Maybe next slide.
  • 00:31I think many of you join us
  • 00:33and are connected with us in.
  • 00:34In over with you and and with your
  • 00:37families and it's I want to take
  • 00:39just a few minutes to acknowledge
  • 00:41the upcoming cancer awareness funds.
  • 00:42And September I'm going to just
  • 00:44say is a busy month for us.
  • 00:47So first up is.
  • 00:50Our prostate Cancer Awareness month and.
  • 00:56Prostate cancer, as some of you may know,
  • 00:58is one of the most diagnosed and treated
  • 01:00cancer in men at smilow Cancer hospital,
  • 01:02accounting for 17% of all male cancers.
  • 01:06BC here and our oncologist, urologist,
  • 01:09radiation oncologists and other specialists
  • 01:12partner together to provide specialty
  • 01:14care to men diagnosed with this disease.
  • 01:17So if you have please talk to the
  • 01:19men in your life to talk to their
  • 01:21health care provider about screening.
  • 01:23This is it screen screen cancer Next up.
  • 01:26Also, is gynecological
  • 01:28Cancer awareness month?
  • 01:29And similarly our team of gynecological
  • 01:32oncologists and other specialty
  • 01:33physicians provide excellent care
  • 01:35to women diagnosed with ovarian,
  • 01:37cervical, endometrial and other cancers.
  • 01:41And for nearly twenty years
  • 01:42or discovery to cancer,
  • 01:43cure program has led research projects
  • 01:46for earlier detection of ovarian
  • 01:49cancer and supported clinical care
  • 01:51for women at Yale and in Smilow.
  • 01:54Enable you move to the next slide.
  • 01:56I I mentioned it's it.
  • 01:57There's a lot of cancer awareness.
  • 01:59September, I think it's so.
  • 02:00It's want to acknowledge all of the all
  • 02:03of those in terms of raising awareness.
  • 02:06Next up is blood Cancer Awareness
  • 02:08Month and the Smilow Cancer
  • 02:09Hospital hematology program,
  • 02:11led by Doctor Stephanie Lee,
  • 02:13has expanded over the last several years
  • 02:16to provide expert care to patients through
  • 02:18our multiple myeloma and gammopathy
  • 02:21program classical hematology program.
  • 02:24Leukemia,
  • 02:24lymphoma,
  • 02:25stem cell transplant and these
  • 02:27newer therapies.
  • 02:28The car T cell programs that are
  • 02:30available are transplant program is
  • 02:32also a member of the National Marrow
  • 02:34Donor program and is accredited
  • 02:36as a major transplant center under
  • 02:38Dr Stuart Seropian's leadership.
  • 02:42I also want to acknowledge thyroid
  • 02:44cancer Awareness month and the
  • 02:46incidence of thyroid cancers.
  • 02:48Unfortunately,
  • 02:48actually rising in for women in Connecticut.
  • 02:51Dash,
  • 02:51Jennifer Ogilvie joins Milo Cancer
  • 02:53Hospital earlier this year as Chief
  • 02:56of Endocrine Surgery and is leading
  • 02:57a team including her endocrinologist
  • 02:59and medical oncologist to care for
  • 03:02patients diagnosed with thyroid cancers
  • 03:04are cancer prevention and control
  • 03:07research program is also actively
  • 03:09receives researching this rising incidence.
  • 03:12To determine the causes of this
  • 03:14and find ways to prevent it Next
  • 03:16up and then last but not least is
  • 03:19childhood Cancer Awareness Month.
  • 03:20We also celebrate our littlest
  • 03:22patients and the tremendous care or
  • 03:25pediatric hematologist and oncologist
  • 03:26in child Life team provided smilow
  • 03:29cancer hospital and in the Yale
  • 03:31New Haven Children's Hospital.
  • 03:32I'm also really excited to announce
  • 03:35that next month we'll welcome Doctor
  • 03:37Lakshman Krishnamurthi as our new
  • 03:39Chief of Pediatric Hematology
  • 03:41Oncology and bone marrow transplant.
  • 03:44Questionable through more seasoned,
  • 03:46accomplished pediatric hematologist
  • 03:47oncologist and an international
  • 03:49leader in bone marrow transplant.
  • 03:52He's joining us from Atlanta Berries,
  • 03:53a professor of Pediatrics at Emory
  • 03:55University School of Medicine
  • 03:57and director of the bone Marrow
  • 03:59Transplantation program there.
  • 04:00So that was a lot of raising awareness
  • 04:02of all the cancers that are this month.
  • 04:05Next up,
  • 04:06it's the closer to free bike ride.
  • 04:08I know that this is an event that
  • 04:10has been important to Connecticut
  • 04:11and all of our all of our
  • 04:13patients. In our families, etc.
  • 04:15It's on Saturday, September 11th.
  • 04:17I know we were briefly hoping
  • 04:19it would become an in person,
  • 04:21but it has once again moved to
  • 04:23a virtual event to protect and
  • 04:24give safety to all our writers,
  • 04:26volunteers and community.
  • 04:27I'm could guarantee you the spirit will
  • 04:30be strong in all of the participants,
  • 04:32so even though it's virtual,
  • 04:34I know many of you participated in
  • 04:36this and I encourage you to register
  • 04:38and join the event online or donate
  • 04:40to support a rider or ride closer to
  • 04:43free dot or you can log on and on the
  • 04:46site on right closer to free.org.
  • 04:48100% of the funds go to support patch
  • 04:51patient carrots Milo Cancer Hospital in
  • 04:53Cancer Research at our Cancer Center.
  • 04:56I thought I would also talk very briefly
  • 04:58about COVID data from our what we are seeing.
  • 05:01So in terms of if you're wondering,
  • 05:04the hospital Yale New Haven Health
  • 05:06System has made vaccination mandatory
  • 05:09and over 27,000 of our employees
  • 05:11have been vaccinated and in terms of
  • 05:13how many vaccines we have delivered,
  • 05:15I think you can see that over 200,000.
  • 05:17And if you see the care that continues
  • 05:20to happen along with cancer care,
  • 05:22we continue to provide care to our camp
  • 05:24COVID patients over 12,000 patients
  • 05:26have been discharged and released,
  • 05:28and as health system has had the lowest
  • 05:30mortality in the statement compared
  • 05:32to the all the hospitals I know we all
  • 05:34contribute and we're proud of that
  • 05:36of the care we provide to our Community.
  • 05:38So just wanted to take a minute to
  • 05:40acknowledge that because I know this
  • 05:42is something we're all living with.
  • 05:44Next slide, Renee, please.
  • 05:46Alright.
  • 05:47So if you have suggestions or questions.
  • 05:49About these forms,
  • 05:50I do want you to take the time to reach
  • 05:52out to us and all the ways Facebook,
  • 05:54Twitter, etc.
  • 05:55You can use old fashioned emails,
  • 05:57cancer and answers at yale.edu
  • 05:59and follow us on social media.
  • 06:02I know Renee Gadets team since a
  • 06:04lot of information on the various
  • 06:06social media formats,
  • 06:07so again we want to hear from you.
  • 06:09You are part of our community and
  • 06:11we feel very connected with you
  • 06:12and we want to make sure we're
  • 06:14supporting you and all your questions.
  • 06:17With that I'm going to share
  • 06:19the agenda for tonight.
  • 06:20First up is our new chief for Breast
  • 06:22medical Oncology and the director of
  • 06:24the Breast Center at Smilow Cancer
  • 06:26Hospital will be Dr Maryam Lustberg,
  • 06:27who has joined us recently
  • 06:29from the Ohio State,
  • 06:30and she's going to be talking about the
  • 06:33impact of COVID on cancer survivorship.
  • 06:35I would like you know she will talk
  • 06:37and then we'll have Q&A and after
  • 06:39that we're going to talk about,
  • 06:40I suspect,
  • 06:41which there going to be a lot
  • 06:42of questions and answers.
  • 06:43It's immunocompromised patients
  • 06:45and 3rd dose vaccinations.
  • 06:47And doctor Om Deshpande,
  • 06:49who's our executive director in
  • 06:50charge of this program for Yale,
  • 06:52New Haven Health,
  • 06:53has joined us.
  • 06:54Thank you Doctor Deshpande
  • 06:56doctor Kevin Billingsley.
  • 06:57Many of you know him.
  • 06:58He's our chief medical officer
  • 07:00for Smilow Cancer Hospital and
  • 07:02will be giving us the updates.
  • 07:03And he's joined by a team and we want to
  • 07:05make sure we answer all the questions.
  • 07:07Lisa Barber ODA,
  • 07:09who's the program director and oncology
  • 07:11education Dr Huntington who is in
  • 07:14hematology and can answer those very
  • 07:16specific questions for hematology,
  • 07:18hematologic malignancies, patients.
  • 07:20Miss Lester, who I know many of you.
  • 07:23If you've joined us in the past,
  • 07:24know her she's her chief nursing
  • 07:26officer and vice president.
  • 07:27Patient services for hospital
  • 07:29and then Dr Euhus,
  • 07:30their associate CMO for radiation oncology,
  • 07:33is also joining.
  • 07:34Still everybody give a big babe so you can.
  • 07:36They can see your faces in your names are on,
  • 07:39but with that I'm going to turn
  • 07:40it over to our very own doctor
  • 07:42Lustberg to give you an update
  • 07:44on cancer survivorship.
  • 07:46Doctor Losfer take it away please.
  • 07:48Thank you Doctor Raja and
  • 07:50thank you to all the.
  • 07:51Participants tonight in this town hall.
  • 07:55It's wonderful that you're here.
  • 07:57So that we can all have a conversation
  • 08:00about the impact of COVID,
  • 08:02which has changed many things in healthcare.
  • 08:06As many of you know,
  • 08:07and I'm sure many of you have
  • 08:10also been personally impacted.
  • 08:12By many of the changes that we have
  • 08:15all gone through since early 2020,
  • 08:18so this schema here is a.
  • 08:22It captures the work of many of
  • 08:26the collaborate collaborations
  • 08:28that I've had throughout the
  • 08:30country where we were observing.
  • 08:32Kind of what was happening to
  • 08:35healthcare delivery as essentially the
  • 08:37healthcare system for valid reasons
  • 08:39had to come to a halt with with the
  • 08:43mounting cases of COVID in early 2020,
  • 08:46and as you can see we've had multiple waves.
  • 08:50So this is, uh,
  • 08:51this was an artistic depiction
  • 08:54of how multiple cancer survivors
  • 08:56were affected by multiple waves of
  • 08:59COVID as they each came through,
  • 09:01and we with each wave.
  • 09:03We thought this might be the last one,
  • 09:04and so as we're currently
  • 09:07experiencing or fourth wave,
  • 09:08I think it's it's.
  • 09:09It's a telling schema and so with with
  • 09:13many of the national survivorship experts,
  • 09:15I think we we we really had multiple
  • 09:18dialogues in terms of how we could
  • 09:21better support cancer survivors as
  • 09:23they were going through the pandemic.
  • 09:25And to make sure we're all on
  • 09:27the same page in terms of the
  • 09:29definition of a cancer survivor,
  • 09:31because I know that can
  • 09:33be confusing sometimes.
  • 09:34Uhm,
  • 09:34really,
  • 09:35the official National Cancer
  • 09:37Center definition.
  • 09:38Is anyone diagnosed with cancer
  • 09:40from the day one of diagnosis
  • 09:43throughout the rest of their lives.
  • 09:46And obviously there are many
  • 09:48different types of cancer survivors,
  • 09:50and this will also be relevant in
  • 09:52the next segment of this town hall.
  • 09:55When we talk about.
  • 09:57Patients on active treatment versus
  • 09:59patients were not active treatment,
  • 10:01but what we noticed kind as as as
  • 10:04as a COVID-19 was mounting that
  • 10:08there needed to be best practice
  • 10:09is set in place in terms of how we
  • 10:12better communicated with with the
  • 10:14many different cancer survivors,
  • 10:16how we shared information and
  • 10:18how we try to make the best of
  • 10:21things during resource lean times.
  • 10:23When we were going through this crisis so.
  • 10:27Many of these themes you have
  • 10:29seen because the health system
  • 10:31here has really done a terrific
  • 10:34job of responding to this crisis.
  • 10:36But on top of the wave you can
  • 10:38see the the the the box,
  • 10:40assess and anticipate the COVID-19 burden.
  • 10:43And this is exactly what was done.
  • 10:45What is being done?
  • 10:46What will be done?
  • 10:47Which is we are constantly looking at
  • 10:50what our case numbers are doing and
  • 10:53really making decisions in terms of.
  • 10:55You know what?
  • 10:57Whether we need to scale
  • 10:59back from certain events,
  • 11:02whether to keep things fresh.
  • 11:04Also can constantly being in
  • 11:06touch with you in terms of how how
  • 11:10the COVID-19 burden is is doing.
  • 11:13Another theme that emerged for
  • 11:15cancer survivorship and other other
  • 11:17types of cancer care delivery
  • 11:19was other emergence of increased
  • 11:21reliance on Tele health,
  • 11:22which which has been a wonderful asset.
  • 11:27However, we also want to make sure that
  • 11:30cancer survivors also know that it's also
  • 11:32safe to enter the health care system.
  • 11:35There was a lot of fear,
  • 11:37specially in the early months of
  • 11:39the pandemic where certain signs
  • 11:41and symptoms of disease progression,
  • 11:44where perhaps being being ignored
  • 11:46because patients didn't feel safe
  • 11:48to enter the hospital system.
  • 11:50So Tele health absolutely has a place it.
  • 11:53It absolutely enhances care delivery,
  • 11:56but they are there.
  • 11:57Also, instances where a physical
  • 11:59exam is also important.
  • 12:00So really educating our survivors in
  • 12:03terms of signs and symptoms to look for
  • 12:07and to come into the health care system.
  • 12:10If they are very worried or
  • 12:13have a concerning system,
  • 12:14the next piece that really emerged
  • 12:17during the pandemic was the importance
  • 12:19of the health care team that in
  • 12:22order to this is something we've
  • 12:24always known but but COVID really
  • 12:26brought it to to center stage,
  • 12:29which is that the different
  • 12:31health care providers needed to
  • 12:33really work together from primary
  • 12:34care specialists to to oncology
  • 12:36specialist continued collaboration
  • 12:38with nurses and advanced practice.
  • 12:41Providers another area that impacted
  • 12:44are cancer survivors with access to
  • 12:47diagnostic imaging and services and
  • 12:49this is something that we can reassure
  • 12:51you now that that things are back open.
  • 12:54We want you to come in for your screenings.
  • 12:57This is a central component of cancer
  • 13:02survivorship and these services are
  • 13:05available now and it's really important to.
  • 13:08To follow a guideline,
  • 13:11concordant care and what we unfortunately
  • 13:15saw during the pandemic in in some of
  • 13:17the earlier waves was that there was
  • 13:20a sharp drop off of cancer screenings,
  • 13:22and now we're seeing that starting
  • 13:25cancers are actually presenting
  • 13:27at more more more advanced stages.
  • 13:30You'll hear a lot more about the next box,
  • 13:33which is the concept of risk stratification.
  • 13:36We we we want to be really giving
  • 13:40personalized care to all of you,
  • 13:42which means your vaccine recommendations
  • 13:44and a lot of your care.
  • 13:47Recommendations and cautions are
  • 13:48dictated by your level of risk,
  • 13:51which is in many ways determined
  • 13:54by the type of cancer you have and
  • 13:56the type of cancer treatments that
  • 13:58you are receiving.
  • 14:00So a lot more information will come
  • 14:02up in the next segment of the town
  • 14:04hall and also in the panel discussion.
  • 14:07And uhm.
  • 14:08The next box focusing on outreach
  • 14:11and education.
  • 14:12This is something that we feel very
  • 14:15passionately about and inspire low,
  • 14:16and we this is one of the many reasons
  • 14:19we're having town halls like this
  • 14:22is that we're one community and we
  • 14:24want to share with you information
  • 14:27as it becomes available and to really
  • 14:30focus on state of the art patient
  • 14:33education through our websites,
  • 14:35social media as well as these types
  • 14:37of live events.
  • 14:39And then most importantly,
  • 14:41I think it's important to take a pause.
  • 14:43All of us and really acknowledge what,
  • 14:46what, what, what, these past year,
  • 14:49year and a half has done to us
  • 14:51and in our workforce and our
  • 14:54families in our relationships.
  • 14:55I think it's up there.
  • 14:58There has been a significant like the
  • 15:02social impact of COVID-19 It's important
  • 15:05to to take a moment and realize that,
  • 15:08and also know that there are
  • 15:11many resources available to.
  • 15:13To address these psychosocial needs and to
  • 15:16be able to ask for help to to know that.
  • 15:20Social distancing does not necessarily
  • 15:22have to mean social isolation and
  • 15:24that there are different ways
  • 15:25that we can all reach out to each
  • 15:28other and support one another.
  • 15:29And you're part of our community,
  • 15:32and so I just want to encourage
  • 15:34you to continue to to reach out.
  • 15:37So this was the schema was initially created
  • 15:40by my colleagues early on in the pandemic,
  • 15:43and the next figure reiterates the similar
  • 15:47themes that I'm not going to go over,
  • 15:50but it highlights how we
  • 15:52thought that the pandemic.
  • 15:53Was over and then into 2021 we realized.
  • 15:56Gosh we needed to reassess.
  • 15:58What are survivor needs were and
  • 16:00you can see a lot of the same
  • 16:02themes that I already covered,
  • 16:04including you know do not delay
  • 16:07needed and in person visits.
  • 16:09Uhm,
  • 16:10really it would continue to focus on
  • 16:13healthy habits and healthy behaviors.
  • 16:17And additional themes emerged,
  • 16:19including the financial impact of
  • 16:22COVID-19 because it was impacting
  • 16:25survivors in terms of.
  • 16:27Many different issues in terms
  • 16:29of changes and work patterns,
  • 16:31and this may have impacted their ability,
  • 16:35ability to access health insurance,
  • 16:38or be able to pay for certain services so.
  • 16:43Or I think it just highlighted that
  • 16:46these needs continued even into
  • 16:49the into the third and 4th wave.
  • 16:53And that the main upshot was to really
  • 16:58be open to using the health care facilities,
  • 17:01acknowledge the impact of COVID,
  • 17:03and know that you know many
  • 17:05cancer services cannot wait that
  • 17:08that that that cancer itself is.
  • 17:10Is not an elective procedure that
  • 17:12was one of the other myths that that
  • 17:14sometimes emerges like Oh well,
  • 17:16cancer surgery can be can be postponed
  • 17:18or a bit, but we we we really,
  • 17:21I think,
  • 17:22have a better understanding that all
  • 17:25our patients and cancer survivors
  • 17:27need ongoing care and we are.
  • 17:30We are committed to providing that
  • 17:33with you and in the subsequent segments
  • 17:35of this town hall you'll hear more
  • 17:38about how we can help optimize your health.
  • 17:41As we continue to go through this 4th wave,
  • 17:44so I'll stop there to make sure we have
  • 17:46time for other segments and for questions.
  • 17:49Thank
  • 17:49you doctor. Lustberg I think
  • 17:50will save the questions.
  • 17:51There are some questions
  • 17:53around protecting survivors.
  • 17:54I'm going to leave it at the end
  • 17:55because I think a lot of the next
  • 17:57discussion will also address this.
  • 17:58I think the points that I heard
  • 18:00which I loved, social distancing,
  • 18:02doesn't mean social isolation.
  • 18:04We need to remember this part of her
  • 18:06can taking care of our community,
  • 18:08and I think if everyone didn't
  • 18:10get this then make sure you get.
  • 18:12While you're screening done because
  • 18:13I think last year we did see a
  • 18:16lot of gaps as things shut down,
  • 18:17so thank you so much I I suspect there
  • 18:20will be more and more questions,
  • 18:21but I want to sort of come I
  • 18:24someone saying they cannot hear me.
  • 18:27Uhm? Or others hearing me,
  • 18:29just give me a thumbs up if you can hear me.
  • 18:31OK doctor Deshpande.
  • 18:32Others OK miss our fee I'm hoping
  • 18:35that we can get you connected or
  • 18:37enable reach out to you offline
  • 18:39but I'm going to move on to the
  • 18:41next segment because I suspect
  • 18:43there are lots and lots and lots of
  • 18:45questions around the booster shots.
  • 18:46So with that Doctor Deshpande,
  • 18:48I think you're starting this segment.
  • 18:51Or Doctor Billingslea or Miss
  • 18:52Barbarito I I am actually I'm going
  • 18:54to pass it on to the panel so.
  • 18:57OK, I think we could probably tag team and,
  • 19:00uh, but uh, thank you Doctor Who
  • 19:02and thank you for having me so.
  • 19:05You know, as was mentioned earlier,
  • 19:08the health system has actually
  • 19:10done over 450,000 vaccinations and
  • 19:13has vaccinated approximately 200
  • 19:15and 15,000 people individually.
  • 19:17You know on the point that Doctor
  • 19:20Who brought up that are about
  • 19:22our health care workers.
  • 19:23We jointly with our other
  • 19:26hospitals in in the state,
  • 19:29had really committed to a vaccine
  • 19:32mandate and we were at 81% of
  • 19:35our of our full workforce.
  • 19:37Which includes our medical staff
  • 19:39prior to the mandate and we are
  • 19:41making significant progress.
  • 19:43Our deadline for the first dose
  • 19:44was actually yesterday and we're
  • 19:45still waiting on the final data,
  • 19:47but we're we are making a lot of
  • 19:49progress and we anticipate that we
  • 19:51will get to our goal by the end of September,
  • 19:54which is, you know,
  • 19:55part of our ongoing commitment to providing,
  • 19:57you know, the really safest care
  • 19:58to all of our patients.
  • 20:00And of course,
  • 20:02most importantly are those who
  • 20:04are had increased vulnerability.
  • 20:06With regards to the immunocompromised
  • 20:09population there,
  • 20:10I'm sure most of you are aware
  • 20:13of the fact that a third dose was
  • 20:17approved sometime ago and thus
  • 20:19far in the state of Connecticut,
  • 20:20about 10,000 of these doses have
  • 20:22been administered and around
  • 20:248:00 or 900 of these doses have
  • 20:26been administered at Yale,
  • 20:27New Haven Health,
  • 20:28so the process really has not changed
  • 20:31from our first from our first wave,
  • 20:34the first two doses it's very easy to.
  • 20:37To go through the process and get scheduled,
  • 20:40uh,
  • 20:40the the website is is on the
  • 20:42bottom of this slide.
  • 20:43You can also call our call center at 833.
  • 20:46Ask why NHH and they can also
  • 20:49telephonically schedule you.
  • 20:51The process is fairly seamless
  • 20:54and straightforward.
  • 20:55You really have to attest to the fact
  • 20:58that you you meet the definition of
  • 21:00them in a compromise and as a part of
  • 21:03that workflow we really do highlight
  • 21:05the different things that that.
  • 21:07Are there constituting any compromise
  • 21:09per the CDC's recommendation,
  • 21:11and the language has changed a fair
  • 21:13amount over the last few weeks of thing
  • 21:15as things have gotten better and better,
  • 21:17so I think that our language as you
  • 21:20actually schedule through the website,
  • 21:22it has been updated.
  • 21:23I don't know.
  • 21:24There are website where it talks about LVK
  • 21:27seen eligibility has been fully updated,
  • 21:29so just stay tuned.
  • 21:30That will also be updated
  • 21:32by tomorrow morning.
  • 21:33Kevin Lisa, if you do,
  • 21:35do you want us to go through the specific?
  • 21:37I can't.
  • 21:38OK there we go.
  • 21:39Thank you doctor. Just pandi.
  • 21:41You know, I I'd like to just
  • 21:43build on a couple of the comments
  • 21:46made by my colleagues. First off,
  • 21:49to echo Dr Lustberg we fully understand.
  • 21:53On behalf of our patients and their
  • 21:57families that navigating a cancer
  • 21:59diagnosis and cancer care and
  • 22:01getting through the cancer journey
  • 22:04is difficult and trying at best.
  • 22:07But when our patients and families
  • 22:09confront the challenges of a global
  • 22:12pandemic layered on top of their diagnosis,
  • 22:15it truly creates a difficult mix.
  • 22:19Our goal is your cancer care team is to make.
  • 22:23Navigating that difficult mix as easy
  • 22:26as possible and as safe as possible.
  • 22:30And as Doctor Deshpande indicated.
  • 22:34Part of that is that we,
  • 22:36as health care providers,
  • 22:38are committed to getting vaccinated
  • 22:40ourselves so that when you come
  • 22:42into our facilities or offices,
  • 22:44you know you're safe.
  • 22:45Our health care system has been in
  • 22:48the lead in the state of Connecticut
  • 22:50and vaccinating people over 250.
  • 22:52Fifteen thousand people vaccinated,
  • 22:55and we're still rolling.
  • 22:57Now with this third dose.
  • 23:00And the question is, you know,
  • 23:02as Doctor Despond indicated,
  • 23:03this has been a moving target and we
  • 23:07have just updated our recommendations.
  • 23:09The original description was for
  • 23:12immuno compromised patients to be
  • 23:14immediately eligible for a third dose
  • 23:17vaccination to boost their immunity
  • 23:20and the truth is that the vast
  • 23:23majority of our patients are actually
  • 23:26within this eligibility criteria.
  • 23:28So just to go through this in a
  • 23:30little bit more detail and you can
  • 23:32certainly read along with me if you
  • 23:34are this is and this is part of our
  • 23:37attestation language on our website.
  • 23:39If you are an individual who has
  • 23:41a diagnosis of cancer and you've
  • 23:43met at least one of these criteria,
  • 23:45you are eligible for an immediate
  • 23:48vaccination either within our system
  • 23:50or within one of the commercial
  • 23:52sites around the state.
  • 23:54Meaning that you have received
  • 23:56some cancer therapy,
  • 23:57including really the entire
  • 23:58spectrum of treatment for cancer.
  • 24:01For a solid tumor within one year of your
  • 24:04initial COVID-19 vaccination series.
  • 24:06Or you or someone who may not
  • 24:09have started your treatment,
  • 24:10but you've been diagnosed with
  • 24:12cancer or recurrent cancer and you
  • 24:15have a treatment plan in place that
  • 24:17will be moving forward that will
  • 24:19include chemotherapy, immunotherapy,
  • 24:21radiation therapy.
  • 24:22And we are even including surgery in that.
  • 24:26Or you were one of these?
  • 24:27One of our patients who were
  • 24:30facing a hematologic disease or
  • 24:33blood cancer diagnosis.
  • 24:34For example, leukemia,
  • 24:35lymphoma, myeloma, or Milo,
  • 24:38dysplastic syndrome,
  • 24:39or other chronic myeloproliferative
  • 24:41conditions.
  • 24:42You are also eligible and that
  • 24:46eligibility is broadly spanning in time.
  • 24:50Or you were a patient who's received
  • 24:52a stem cell transplant or car T
  • 24:55therapy at virtually any time here
  • 24:57at the Smilow cancer hospital.
  • 24:59So.
  • 25:00We're really creating a broad
  • 25:03eligibility structure for patients
  • 25:06to derive the additional protective
  • 25:08effect of that third dose vaccine,
  • 25:12and we are in alliance in alignment
  • 25:16with our peer institutions through the
  • 25:19National Comprehensive Cancer Network,
  • 25:22as well as the updated CDC guidelines.
  • 25:28Next slide.
  • 25:33That actually may be the end
  • 25:35of our slides. Renee, UM.
  • 25:40Yeah, I think we want to
  • 25:42leave time for questions.
  • 25:43Doctor Billingslea,
  • 25:43so I think there's a lot of questions.
  • 25:45The first one is from Miss Monaghan.
  • 25:47Asking for advice for caregivers,
  • 25:49spouses, Visa V protecting cancer
  • 25:52survivors from COVID would be appreciated.
  • 25:58And I also want to make sure
  • 26:01that we introduce our panelists.
  • 26:04Uh, I see my colleague Doctor Huntington
  • 26:08who's also available to answer
  • 26:10questions in the heme malignancy space.
  • 26:12Uhm, we introduce these folks earlier,
  • 26:14but Kim Slusser at least brought
  • 26:16us so all can help with answering
  • 26:18the answering our question.
  • 26:20Would you like to take that one for
  • 26:22sure? I know it's a.
  • 26:23It's a great question on highlighting.
  • 26:26The importance of caregivers. First of all,
  • 26:29thank you for all that you do come.
  • 26:32It's a way we are only the thing stages are
  • 26:36truly recognizing what impact caregivers
  • 26:39actually have during the cancer continuum.
  • 26:43But to specifically answer your question,
  • 26:46the the biggest thing you can do is to be
  • 26:49normally vaccinated for standard of care
  • 26:52as well as continuing to practice masking.
  • 26:56In high risk situations,
  • 26:59good hygiene, and if there are any,
  • 27:02any symptoms that that,
  • 27:04that that that raises the question in
  • 27:06your head is could this be covered?
  • 27:08Could this happy Kovit getting tested?
  • 27:11Because testing it is is available
  • 27:14and so those are those are the
  • 27:18precautions that you can take as
  • 27:21caregivers to to protect higher risk
  • 27:23individuals at this point in time.
  • 27:27Thank you, Mary. Come next question.
  • 27:30I think this may be doctor
  • 27:32Deshpande your alley.
  • 27:33Should there be a delay between the
  • 27:35flu shot and the third COVID dose?
  • 27:37If So what is the suggested time frame?
  • 27:39I know you've answered it,
  • 27:41but maybe just give some more details.
  • 27:43Thank you.
  • 27:46So the Advisory Committee
  • 27:48on Immunization Practices,
  • 27:49which is sort of the the Group of
  • 27:52expert who helps us create the
  • 27:54guidelines for administration here,
  • 27:55have reviewed the data across the
  • 27:57board and have determined that it's.
  • 27:59It seems it appears to be completely safe to
  • 28:02get multiple vaccinations at the same time,
  • 28:04so there's really no reason to could
  • 28:06be concerned that you know either the
  • 28:08flu or the code vaccine would be less
  • 28:11effective by getting them at the same time.
  • 28:13Again, the only thing is that you
  • 28:14know if you get both of them.
  • 28:16The COVID vaccine is likely to result
  • 28:18in some transient side effects.
  • 28:20The usual muscle aches a little bit of fever,
  • 28:23headaches, things of that nature which
  • 28:26all resolved within two to three days.
  • 28:28So you you are going to you.
  • 28:31You can easily experience those things,
  • 28:33but again, those are.
  • 28:34Those would be experienced regardless,
  • 28:35so it is completely safe to
  • 28:36get them both at the same time.
  • 28:38And actually as we are planning
  • 28:40forward for our health care workers,
  • 28:42we are,
  • 28:43we're figuring out the workflow to
  • 28:44do that exactly that so it there's no
  • 28:47reason to be concerned in that regard.
  • 28:49OK,
  • 28:50thanks, start responding.
  • 28:51I think the next one,
  • 28:52which is also important and I suspect
  • 28:55front and center on following the
  • 28:57question that doctor lost forgot.
  • 28:59When will the caregivers of cancer
  • 29:01patients be eligible for the booster?
  • 29:04I know this is an area that's up and sort
  • 29:06of there's a lot of data I don't know.
  • 29:08Doctor Billingslea,
  • 29:08are you taking this one?
  • 29:12I'd be happy to you know.
  • 29:15What I think we all would like to
  • 29:18share is that this is. One of these.
  • 29:23Areas that is evolving very quickly
  • 29:26and I think that if you follow the
  • 29:30CDC commentary and the advice of
  • 29:33governing bodies around the country,
  • 29:36there is accelerating movement
  • 29:38towards opening accessibility for the
  • 29:41general population for a third dose of
  • 29:44vaccination in the very near term. Now,
  • 29:47like the original rollout of the vaccine,
  • 29:50I suspect that there will be a staged.
  • 29:54Approach to this with the most high
  • 29:57risk individuals being encouraged
  • 29:59to seek that third dose the soonest
  • 30:02particularly paid folks in in
  • 30:05long term care facilities,
  • 30:06the elderly,
  • 30:07and probably health care personnel.
  • 30:10But I think that that very,
  • 30:12very quickly you will be seeing
  • 30:16broad eligibility for a third dose.
  • 30:19Doctor
  • 30:20Deshpande, anything else you'd
  • 30:21like to point out 'cause you manage
  • 30:23this for the entire health system?
  • 30:24Anything else we should point?
  • 30:26I know this is a we'll be seeing
  • 30:28more information. I suspect. Pretty
  • 30:29short. Yeah, yeah we will
  • 30:31be seeing more information.
  • 30:32I I think that you know and I believe
  • 30:34in the some of the documents that
  • 30:35were some of the questions that
  • 30:37had been submitted previously.
  • 30:39Someone had asked to comment on a
  • 30:40New York Times article that speaks
  • 30:42to the sort of the controversies
  • 30:44around waning immunity.
  • 30:45And it gets a little complicated,
  • 30:49so I'll try not to get too deep.
  • 30:50Into the weeds,
  • 30:51but I think the key thing here is
  • 30:53that there are individuals who are
  • 30:55clearly immunosuppressed or for
  • 30:57some reason immunity does truly win.
  • 30:59And you know the cancer patients and
  • 31:02you know everyone who's receiving the
  • 31:04therapy is that doctor Billingsley just
  • 31:07outlined clearly fall into that category.
  • 31:09Other people who are also probably
  • 31:11in that category of people over
  • 31:13the age of 65 and have you know,
  • 31:15even if they have no other
  • 31:17comorbid conditions.
  • 31:18It is a little less clear about
  • 31:21younger people and who may
  • 31:23not have these comorbidities,
  • 31:25so I think that is some of the
  • 31:27data that has to be parsed.
  • 31:29I do think you know,
  • 31:30based on the the signaling
  • 31:31from the White House,
  • 31:32there was a desire to make this,
  • 31:34you know available across the board
  • 31:36and we were planning frankly for that
  • 31:39eventuality towards the end of September.
  • 31:41But I think we're also hoping that
  • 31:42there's a little more clarity
  • 31:44about who will actually benefit
  • 31:45'cause the New York Times article,
  • 31:47that that was sort of that
  • 31:48was in the questions.
  • 31:49Highlighted the fact that you
  • 31:51know four people who are otherwise
  • 31:53healthy and of our it's it's really.
  • 31:55There are certain groups that clearly
  • 31:57will benefit and then there are.
  • 31:58There may be others who don't.
  • 31:59So I think that we just need a
  • 32:01little more information and with
  • 32:02regards to the original question is
  • 32:04to when caregivers will be eligible.
  • 32:07It really depends on the national
  • 32:09guidelines that are that are
  • 32:11released in the meantime.
  • 32:12Of course you know the key
  • 32:14things that you know.
  • 32:16Mask wearing,
  • 32:16universal mask wearing hand hygiene
  • 32:18and being particularly careful about.
  • 32:20All the other infection prevention
  • 32:23behaviours are or absolutely
  • 32:24obviously continue to be critical.
  • 32:28Thank you and I think you know
  • 32:29the New York Times articles.
  • 32:30For those of you may not have read it,
  • 32:32I think talks about you know the
  • 32:34risk benefit, and I think this
  • 32:35is an area we continue to learn.
  • 32:36I think 18 months later we know
  • 32:38a lot more of this disease,
  • 32:40but it also changes,
  • 32:41so I think it's it gets into
  • 32:43a lot of details around this.
  • 32:44I think. Certainly there are clear
  • 32:46categories with immuno suppression.
  • 32:47Bear it's beneficial but you
  • 32:49know if you're young and healthy.
  • 32:51Do you benefit from a booster?
  • 32:52I think it's something will bill figure out,
  • 32:54but I think we're all learning a lot
  • 32:57with this disease also and collectively.
  • 32:59Uhm, dealing with this, uh,
  • 33:02there's a question around
  • 33:03getting the Moderna.
  • 33:04If you got your last two doses of Moderna
  • 33:06and now you're trying to get your booster,
  • 33:09someone saying I can't get
  • 33:10an appointment at Yale.
  • 33:12They're waiting on a shipment Lisa,
  • 33:13would you like to take this
  • 33:15one or doctor Deshpande?
  • 33:16I don't know who wants to take this one.
  • 33:18It looks like it's gonna
  • 33:19say that responded probably.
  • 33:21I know it is.
  • 33:22I figured that I would just give him a break.
  • 33:24It's OK, no problem.
  • 33:26So yeah, we so the good thing is
  • 33:29that there really is enough vaccine.
  • 33:31That's available so we can
  • 33:33absolutely are ordering a.
  • 33:35We are certainly ordering enough and
  • 33:36we will have it available. You know,
  • 33:39the number of for this initial group.
  • 33:41We've only we've opened a
  • 33:43limited number of of sites,
  • 33:45mostly in RMG sites,
  • 33:46and we're working to create some
  • 33:48popups for smilow clinics as well.
  • 33:51But there there is absolutely availability
  • 33:53and we will make sure that Moderna
  • 33:55will be an option that will that
  • 33:57will that we will certainly offer.
  • 33:59I think when when all is.
  • 34:02Told the split between Moderna and Pfizer.
  • 34:05I think we actually administered
  • 34:06more Pfizer than Moderna were.
  • 34:07Actually I'm sorry.
  • 34:08More Moderna than Pfizer so
  • 34:10we will absolutely have those
  • 34:12available as we go forward.
  • 34:14That responded don't go away I.
  • 34:16I think there's another
  • 34:17question following this.
  • 34:18If you got Pfizer initially should you?
  • 34:21Can you get the Moderner Moderna initially?
  • 34:23Can you switch to Pfizer?
  • 34:24So can you sort of share
  • 34:27the combinations? Yeah,
  • 34:28it's a. It's a great question and you know
  • 34:30the the bottom line is that we really have.
  • 34:33We are following the CDC's guidelines,
  • 34:35which are really saying that you
  • 34:36have to get the same version of the
  • 34:39vaccine that you got originally.
  • 34:41There's a lot of interest.
  • 34:42There's a lot of research.
  • 34:44That's actively going on here.
  • 34:47There's a theoretically a lot of
  • 34:49people have sort of had played
  • 34:51out the value of vaccine mixing,
  • 34:53but it really needs to be fully
  • 34:54studied in a rigorous fashion,
  • 34:56and we don't have those data to say
  • 34:58that it's safe and truly efficacious,
  • 34:59so we're waiting for those trials.
  • 35:01At present, the the the.
  • 35:05The guideline,
  • 35:06the recommendation that we are following,
  • 35:07is that you you get the same kind of
  • 35:10vaccine that you got the first time.
  • 35:11The first two times and
  • 35:13we did get some questions on
  • 35:15email prior to this event,
  • 35:16as people register the last
  • 35:17one on this and there were two
  • 35:19questions which seem similar.
  • 35:20People who had the J&J vaccine,
  • 35:23should they be getting a
  • 35:24booster from Pfizer Moderna
  • 35:25or wait to see what J&J does?
  • 35:28Yeah, so this is all we have to wait.
  • 35:30At present we are not able to provide
  • 35:32an M RNA vaccine for them at President.
  • 35:34Did JJ has concluded a trial.
  • 35:37Of the a second booster, because you'll
  • 35:40recall that the J&J is a one shot,
  • 35:42was was a one shot vaccine and we
  • 35:45are still waiting for the actual
  • 35:48trial data to understand what benefit
  • 35:50and how how great the benefit is.
  • 35:52So they they've issued a press release
  • 35:54but we can't go by press releases.
  • 35:56We have to wait until we have.
  • 35:57We really have full transparency
  • 35:59to the outcomes data.
  • 36:00Thank you.
  • 36:03I think the next one is for you Doctor
  • 36:06Huntington neutropenia with with.
  • 36:08Angus, I probably said it wrong,
  • 36:10but no treatment yet qualify
  • 36:12for third vaccine. Yeah,
  • 36:14I. I think you know our
  • 36:16guidance has evolved over time.
  • 36:17So I think initially the CDC really
  • 36:20was focused on active treatment.
  • 36:22But for him malignancies oftentimes
  • 36:25we won't actually vaccinate before we
  • 36:27start the most oppressive therapy.
  • 36:28And so I think our current guidance
  • 36:30would be that some of that has engulfed
  • 36:33neutropenia foramina suppressed and they
  • 36:34would fall under the new category of
  • 36:36of being allowed to have a third dose.
  • 36:38Just want to.
  • 36:39Had one UM, kind of feature about
  • 36:41think about third dose versus booster.
  • 36:43Many of my patients didn't respond to
  • 36:45the first 22 doses and so our goal of
  • 36:47the third dose is really to get those
  • 36:49folks that didn't have any antibody
  • 36:51response to having a response a little
  • 36:53bit different when we think about the
  • 36:55Community about people that you know,
  • 36:5795% of the people on those Moderna
  • 36:59and Pfizer vaccines made antibodies.
  • 37:01Many of our patients were
  • 37:03not those of those folks.
  • 37:05They don't have antibodies,
  • 37:05and so the third dose for them
  • 37:07is a little bit different,
  • 37:08so that's why I think the timing is.
  • 37:09Also a little bit more nuanced in
  • 37:11terms of not waiting eight months,
  • 37:12but really within 28 days or
  • 37:14more after a second dose,
  • 37:16you can get a third
  • 37:16dose. Thank you Doctor Huntington.
  • 37:18You answered the question that came
  • 37:20through our chat earlier and you
  • 37:23answered that that immunosuppressed
  • 37:24people do not mount a response,
  • 37:26so they need their third dose a little
  • 37:29sooner versus those of us who mounted and
  • 37:32gaining immunity are waiting the time.
  • 37:34I think this has been answered,
  • 37:35but doctor Lustberg would you
  • 37:37like to just add more detail?
  • 37:38Those taking anastrozole?
  • 37:39Daily basis count as amino suppression
  • 37:42and can you get a boost right?
  • 37:43Think the answer is yes,
  • 37:45but anything else you want to add for
  • 37:47other types of hormonal therapies etc.
  • 37:49Yes, so no. I completely agree as my
  • 37:52colleague hasn't happened have answered
  • 37:53and that we want to be as broad as
  • 37:56possible and be as inclusive as possible.
  • 37:58It's absolutely true that you know
  • 38:00compared to a patient on immunotherapy
  • 38:03or chemotherapy the the level of
  • 38:05immunosuppression from anastrozole is
  • 38:07is not equivalent, but we we want to.
  • 38:10Protect all our cancer survivors
  • 38:12at various levels of training.
  • 38:14So this is this is this is to be as
  • 38:16inclusive as possible and protect
  • 38:18as many patients as possible.
  • 38:20So yes, any type of hormonal therapy and
  • 38:22I also saw a question on other types of
  • 38:26oral therapy such as PARP inhibitors.
  • 38:28So that applies to that as well,
  • 38:31which is that if you're on any
  • 38:32type of treatment,
  • 38:33go ahead and know that you
  • 38:35are eligible for the booster.
  • 38:38Thank you doctor you,
  • 38:39you've been quiet, you know.
  • 38:41Is there a benefit?
  • 38:41Should you do it after that?
  • 38:43Your booster after six months or eight
  • 38:45months you know people want to know.
  • 38:47Would you wait six months or eight months?
  • 38:49Well, so as a
  • 38:50radiation oncologist it's very
  • 38:52question for me to answer, but I would say
  • 38:55if you the NCCN is trying to be
  • 38:57as broad as possible, and so if
  • 38:59you fit the category of of getting
  • 39:02a booster right away.
  • 39:04You know, I don't think there's a downside to
  • 39:06going ahead and getting
  • 39:07it now. Is there a rush?
  • 39:09I mean there was.
  • 39:09I think there was a question
  • 39:11in there about a patient would
  • 39:12just finish radiation treatment.
  • 39:14Just finished chemo.
  • 39:15I would assume if they had had their
  • 39:17immunization within a couple months,
  • 39:19it's OK to kind of recover from that.
  • 39:20And and there's no extreme rush
  • 39:23to get the the third booster,
  • 39:25so I would say fit it in your schedule
  • 39:27and your lifestyle and know that the
  • 39:29NCCN is being broadened recommending
  • 39:31the booster as soon as it it fits.
  • 39:36Thank you, I'm going to switch to
  • 39:38the question answers, let's see.
  • 39:39Uhm, perhaps I don't know Kim,
  • 39:41do you want answer this?
  • 39:43When are we going to have
  • 39:45psychosocial services?
  • 39:46I have nerd not heard
  • 39:47of any or offered any.
  • 39:50Oh OK, thank you.
  • 39:51I'm so I'm so sorry that you
  • 39:53haven't been offered psychosocial
  • 39:55services due to the pandemic we
  • 39:58have had to alter the way we
  • 40:00offer a lot of those services,
  • 40:02but we do have a lot of our social
  • 40:05work team back in our clinic areas in
  • 40:08some capacity to meet with patients.
  • 40:11And then they also have the ability
  • 40:13to meet virtually with our patients.
  • 40:15So if you have not I, I really apologize.
  • 40:19We're happy to follow up specifically.
  • 40:21And then also on our Yale Cancer Center site,
  • 40:25we have all of our listings of
  • 40:27our integrative medicine offerings
  • 40:29that are all done virtually now.
  • 40:31And we actually saw that patients
  • 40:33liked to do a lot of these things
  • 40:36like meditation and yoga,
  • 40:37right from the comfort of their home.
  • 40:39So we still have those.
  • 40:41And along with our support groups,
  • 40:42so we have a, uh,
  • 40:44a series of many different support groups
  • 40:46and those are being provided virtually now.
  • 40:49I know that some people.
  • 40:51May not have all the technology
  • 40:52they need and we are very sensitive
  • 40:54to that and we are trying to bring
  • 40:57those services back,
  • 40:58but we're also trying to make sure
  • 41:00we still maintain safe distancing.
  • 41:02Social distancing in our clinical areas,
  • 41:05and so it is a balance and we
  • 41:08appreciate our patients flexibility
  • 41:09through this and but please know that
  • 41:12we want to provide these services.
  • 41:15We have our our entire multidisciplinary
  • 41:18multi departmental team here
  • 41:20to take care of you.
  • 41:21And we apologize if those
  • 41:23services have not been offered,
  • 41:24and again,
  • 41:25happy to follow up individually
  • 41:26and and make sure you're connected
  • 41:28with the resources that you need.
  • 41:31Thank you and our Renee.
  • 41:34God has already put a couple
  • 41:35of links on the integrative
  • 41:36Medicine Office offerings
  • 41:37and support group structure.
  • 41:39Less for do you wanna add
  • 41:41any more information?
  • 41:41I thought it was pretty comprehensive,
  • 41:43but if there's something
  • 41:44else you'd like to add
  • 41:45right now, can get such an amazing job.
  • 41:48Yeah, I was just speaking to one of
  • 41:50our social workers and she echoed.
  • 41:51Exactly what this cluster referred to,
  • 41:55and this psychosocial gaps are a common
  • 41:59theme and cancer survivorship throughout
  • 42:02the country not making excuses,
  • 42:06but simply sharing that this is an evolving
  • 42:09area that we're continuing to to to work on,
  • 42:13and it it it really necessitates using
  • 42:17both university and academic resources.
  • 42:20In addition to also liaisoning with our
  • 42:23community of mental health resources so,
  • 42:25so you're going to see that that that
  • 42:28theme continued to be discussed and
  • 42:29we would love to partner with you to
  • 42:32additionally understand the gaps that you
  • 42:34have experienced so that we can make it
  • 42:36better for you as well as other patients.
  • 42:39Thank you, I'm also looking at questions
  • 42:41that we've received beforehand.
  • 42:42There was a question on I am a patient at
  • 42:45Smilow Cancer Hospital in Waterford and
  • 42:47there are eligible for the third dose,
  • 42:50but I think the vaccine appointments
  • 42:52are not available in New London.
  • 42:55When will they be available?
  • 42:56They could only find an option in Trumbull,
  • 42:58so these are Kim or Kevin.
  • 43:00Would you like to take that one?
  • 43:03Sorry, it's quite specific.
  • 43:04I know this might always keep
  • 43:07saying yeah, I might.
  • 43:08Maybe I can take that. Thank you
  • 43:10Doctor Deshpande. We are. We're
  • 43:12administering vaccines at a Northeast
  • 43:15Medical Group site in New London.
  • 43:18It is available periodically so
  • 43:20I I think maybe please do check
  • 43:23back on the website but I as of.
  • 43:26As of yesterday, I believe we were.
  • 43:27We were vaccinating there and it's
  • 43:29been available for for about a week
  • 43:31so I just please do check back.
  • 43:33It is available.
  • 43:34OK. Thank you so much. There are a
  • 43:37lot of questions around antibodies.
  • 43:39Should you be checking on antibodies?
  • 43:41When should you do the third dose?
  • 43:43So maybe someone who's a very
  • 43:45good immunologist can take this.
  • 43:47One is for this. Who's going to be
  • 43:50brave enough to answer this one?
  • 43:51I think we know the answer is no,
  • 43:53you shouldn't,
  • 43:53but I want someone to answer the question.
  • 43:55I'm happy to you know,
  • 43:57should you be doing routine antibody
  • 43:59tests after your second dose,
  • 44:02patients with multiple myeloma?
  • 44:04Should they take their response
  • 44:06to the vaccine so not everybody
  • 44:08raise their hand all at once.
  • 44:10I think this is,
  • 44:11I think this is a doctor Huntington
  • 44:13and Lisa Barbara question first.
  • 44:18I could do the broad
  • 44:19strokes cotton you could fill in through
  • 44:21details so you know the CDC and our.
  • 44:24You know our oncology national groups do
  • 44:27not recommend routine antibody testing as a
  • 44:30means of measuring response to vaccination
  • 44:33or kind of advising on timing of third dose.
  • 44:37There's a variety of currently available
  • 44:40antibody tests and there's not a real
  • 44:43standardization in those tests which make
  • 44:46it difficult to implement one standard.
  • 44:48So outside of the context
  • 44:50of a research setting,
  • 44:52we're not recommending antibody
  • 44:54testing for our patients today,
  • 44:57and so I think one of the questions was,
  • 44:59well, how do we, you know,
  • 45:00have this information that advises
  • 45:02these third doses and the answer to
  • 45:06that is that antibody testing was done
  • 45:08in the context of big research studies
  • 45:11in labs that are doing good antibody
  • 45:14testing and have given us this data.
  • 45:17And we're hoping to learn more.
  • 45:19This is obviously a very hot topic,
  • 45:21and I think one that will continue
  • 45:23to learn more about and ultimately
  • 45:25hopefully have some standardized
  • 45:27testing in the near future.
  • 45:30But Scott,
  • 45:30I don't know if you want to fill
  • 45:32in any other because we just don't
  • 45:35know how to interpret with the
  • 45:37antibiotics mean in terms of whether
  • 45:38that's clinically relevant and
  • 45:40whether we should be tailoring a,
  • 45:41you know,
  • 45:42not giving a third dose to
  • 45:43someone that has antibodies,
  • 45:44and so the antibodies weren't really part of.
  • 45:48Now giving a third dose and broad
  • 45:50booster regiments if you think
  • 45:52about other nations like Israel,
  • 45:54and so I think the data that supports
  • 45:57what we're doing is not really
  • 45:59requiring the antibody levels.
  • 46:01We do have ongoing clinical
  • 46:02trial or not clinical trials,
  • 46:04but observational prospective studies
  • 46:06available for patients with blood cancer.
  • 46:09So certainly folks that are interested
  • 46:11in kind of contributing to science,
  • 46:13and we have that available
  • 46:16to get antibody test.
  • 46:17But after the second dose.
  • 46:20And also after the third dose
  • 46:21in that month thereafter.
  • 46:23So try and take them while you're
  • 46:24answering all the immunotherapy.
  • 46:26How long should I wait after receiving
  • 46:28immunotherapy to receive the booster?
  • 46:30Yeah, so you know, I think these are
  • 46:32broad strokes in the sense that we
  • 46:33do think that most of our patients
  • 46:35should be having a third dose.
  • 46:36The actual nuances about when the
  • 46:38best timing is is really I think the
  • 46:40discussion that many folks should
  • 46:42have with their treating provider,
  • 46:44particularly those unactive cancer therapy,
  • 46:46including immunotherapy.
  • 46:47There's some medications,
  • 46:50and I use where I would typically
  • 46:51try to wait three months,
  • 46:53perhaps even six months after,
  • 46:55because that blunt antibody response,
  • 46:57but for other therapies it may be
  • 46:58best to give it right, you know,
  • 47:00during treatment.
  • 47:01So I think those sort of questions
  • 47:03you're seeing your provider regularly
  • 47:04on treatment definitely ask them
  • 47:06about the timing of the third dose.
  • 47:08Thank you Lisa. Thank you, Scott.
  • 47:11Anyone else? Anything else?
  • 47:12We want to add Doctor Deshpande, anyone else?
  • 47:15OK, Doctor Lustberg,
  • 47:17there's a question here or whoever
  • 47:18wants else wants to answer.
  • 47:20This was received prior on a prescription
  • 47:23drug for psoriatic arthritis tremfya.
  • 47:26Their primary care has
  • 47:27recommended an additional dose.
  • 47:29Can they schedule an appointment for an
  • 47:31additional dose of the Moderna vaccine?
  • 47:33I'm going to hazard, yes,
  • 47:34'cause it's a immunosuppressive,
  • 47:36but I'd like someone else to just.
  • 47:38Confirm yes, that's that's correct.
  • 47:41Alright, good thanks Yep.
  • 47:44Thank you,
  • 47:45can I just add on the scheduling website?
  • 47:48There is a list of immunosuppressive drugs.
  • 47:51It's not a comprehensive list,
  • 47:52but it does provide some guidance
  • 47:54if patients are wondering if the
  • 47:56drugs they're on meet criteria,
  • 47:57and if you're unsure,
  • 47:59I think Renee included
  • 48:00the call center number on the list
  • 48:02and you can also consult with your
  • 48:05provider that prescribes that
  • 48:07medication to get guidance,
  • 48:09right? Yeah, I did actually check that list.
  • 48:12Trump fire is not on it. So again,
  • 48:13to this point it's not comprehensive.
  • 48:15But it is a interleukin 23 inhibitor
  • 48:17I think, so it it it it buys.
  • 48:19I mean it's it suppresses your
  • 48:22immune system so absolutely.
  • 48:24There's a question also on.
  • 48:26I've received my third Pfizer
  • 48:28shot outside of the system.
  • 48:29How do I mark that on my chart?
  • 48:32I think that's a good question,
  • 48:33and if someone can sure
  • 48:35yes. I mean the nice thing about as long as
  • 48:38you receive that in the state of Connecticut,
  • 48:40there's a there's a statewide database
  • 48:43that every vaccine provider sends data to.
  • 48:46And as of about two months ago,
  • 48:49I believe our Yale New Haven
  • 48:52Health version of EPIC downloads.
  • 48:54All the data, so it doesn't really matter
  • 48:57whether or not you got it through us or or
  • 49:00someone else in the state of Connecticut,
  • 49:02those data are automatically
  • 49:04populated and will show up in epic.
  • 49:06Now if you did get it out of state.
  • 49:10I believe we have a process through my chart
  • 49:12that we're working on putting together.
  • 49:14I don't know that it's it's fully baked,
  • 49:17but if you if you did receive it somewhere
  • 49:19anywhere in the state of Connecticut,
  • 49:21that data will automatically
  • 49:22show up in an epic.
  • 49:24That's wonderful, I think this is,
  • 49:27you know, I'm still grappling my
  • 49:28and I think many of us are still
  • 49:30understanding about the third dose.
  • 49:31But someone asked when will
  • 49:33you need another booster?
  • 49:34How many months after Will
  • 49:364th doses be recommended so?
  • 49:38Really insightful questions.
  • 49:40I'm from Doctor Deshpande.
  • 49:42You're going to take that one again. Also,
  • 49:44I I can get. I can hazard a guess.
  • 49:45I mean, I, you know, I think the the key
  • 49:48thing is these vaccines are are great,
  • 49:51but I think one of what we are
  • 49:53seeing is that as the virus changes,
  • 49:56the vaccines that currently that
  • 49:58were initially programmed may be less
  • 50:00effective against the the changing
  • 50:02physical nature of these viruses.
  • 50:04So I think the question about when are we
  • 50:06in need another dose depends on how the.
  • 50:09Pandemic looks globally if another type of
  • 50:13variant of of of COVID-19 evolves at that.
  • 50:17Against which our current vaccines
  • 50:18are current or less affected.
  • 50:20You know, on the positive side,
  • 50:21these companies have the ability
  • 50:23to so called, you know,
  • 50:25essentially reprogram the vaccine
  • 50:27fairly quickly and trot out new
  • 50:29versions as the as the virus evolves.
  • 50:32We haven't seen that the second
  • 50:33that you know,
  • 50:34the 2.0 version of these vaccines yet,
  • 50:37but just the nature of especially
  • 50:38the M RNA technology,
  • 50:40is such that the time to develop a
  • 50:42a the next version is very rapid,
  • 50:44so it it really depends on when as the.
  • 50:47How the pandemic goes,
  • 50:48but it might be a year from now.
  • 50:50It really depends on what vaccines
  • 50:51were there variants excuse me,
  • 50:53arise
  • 50:53yeah and I think part of it of
  • 50:55course depends not only on what
  • 50:56the variants arise of course,
  • 50:57and also how in Connecticut has done
  • 51:00a fabulous job on things like social
  • 51:03distancing and respiratory's and all
  • 51:04the protection and hand hygiene.
  • 51:05So again, I think good questions.
  • 51:08Things will will keep these forms going
  • 51:10to just keep all of you informed.
  • 51:13Thank you Renee for putting
  • 51:14the phone number 833.
  • 51:16Ask why NHH for vaccine information and.
  • 51:18To schedule the website information is there,
  • 51:22I think the last there's another
  • 51:23question about I've had two Pfizer
  • 51:25shots and the booster and they
  • 51:27never got a physical reaction.
  • 51:29And I think a lot of us, you know,
  • 51:31think that we get a physical reaction.
  • 51:33I'm forming antibody.
  • 51:34How true is that?
  • 51:37Doctor Deshpande, I think you're it. OK,
  • 51:40yeah, it it. Actually you know,
  • 51:43I think the the physical reactions,
  • 51:45the side effects that
  • 51:46that you may experience.
  • 51:48Our confirmatory,
  • 51:49but they are not required,
  • 51:50so the the it's it was very well
  • 51:53characterized that there were
  • 51:55individuals who really, you know,
  • 51:57went through the the two dose series
  • 51:59without any issues with really feeling.
  • 52:01Just great not having anything and
  • 52:03they absolutely had equivalent or
  • 52:05the same sort of protection in terms
  • 52:08of getting symptomatic COVID-19.
  • 52:09And certainly you know,
  • 52:11being hospitalized from COVID-19
  • 52:12so the vaccines can protect you.
  • 52:14The fact that you don't have these
  • 52:16reactions doesn't really mean anything.
  • 52:18Doctor Huntington, Dr Billingsly
  • 52:20anything else you'd like to add for
  • 52:22our cancer patients in regards to that?
  • 52:28No, I I do want to make sure.
  • 52:31Have we touched on any questions
  • 52:33about the Johnson and Johnson vaccine
  • 52:35we did be talking. There were a couple
  • 52:37longsword addressing that
  • 52:39a little bit because I.
  • 52:42I have gotten some questions
  • 52:43from my own patients about that,
  • 52:45and it's a small number and I I just
  • 52:48do want to underscore to our patients
  • 52:50and families that there will we that
  • 52:53if you've had J&J you've not been
  • 52:55forgotten and there will be more
  • 52:57information coming very quickly.
  • 53:01I think I'd just like to add
  • 53:04that even with a third dose,
  • 53:05there may be patients out there
  • 53:06that they don't have a response
  • 53:08to the antibody treatment,
  • 53:08and I think we're really fortunate
  • 53:10enough to have a backup,
  • 53:12which is the monoclonal code
  • 53:14antibody therapy that I think
  • 53:15Gail's done a really good job.
  • 53:17Integrating into the care of patients
  • 53:19with cancer and without cancer.
  • 53:20And so if there's any concern of COVID
  • 53:23when they've been vaccine or not,
  • 53:25vaccinate getting tested
  • 53:26and if it's positive,
  • 53:28calling your provider kind of immediately
  • 53:29to get the monoclonal antibodies.
  • 53:31I really think reduces hospitalizations
  • 53:33and likely saves lives in
  • 53:35particularly these vulnerable
  • 53:36patients that they may not respond
  • 53:38even through the three vaccines.
  • 53:40So I think that that's important.
  • 53:43Any closing words from doctor
  • 53:45you came slosser others any other
  • 53:47closing words from all of you eye
  • 53:49on things we haven't covered?
  • 53:51I covered a lot.
  • 53:52I have to tell you there
  • 53:53were a lot of good questions.
  • 53:55I would just say that that for those
  • 53:57of you at home who are wondering,
  • 53:58you know, do I delay care because
  • 54:00I haven't gotten the booster
  • 54:01or this or that.
  • 54:02Please know that the hospital
  • 54:03is a very safe place to be.
  • 54:04Do not delay your care if you
  • 54:07have any uncertainty, talk
  • 54:09to your care provider.
  • 54:11But cancer is. Is a very
  • 54:13important thing to get treated even
  • 54:15when there's a COVID virus floating
  • 54:17around, so do not delay your care
  • 54:19and we're here for you.
  • 54:20Thank you, doctor you.
  • 54:21I think doctor Lustberg.
  • 54:22I think you commented earlier in
  • 54:24the the hour about how we saw delays
  • 54:27last year and that we're seeing on.
  • 54:29So please, please, please do your cancer
  • 54:32screenings if your or your surveillance.
  • 54:34Those are important.
  • 54:36And then Mr. Armstrong.
  • 54:38I think we did it. You know,
  • 54:39if if it isn't clear enable reach out.
  • 54:41But no, we're not testing for.
  • 54:43Antibodies after the vaccine
  • 54:44to see how we responded.
  • 54:47Once again thank you to
  • 54:48all of you for joining in.
  • 54:49We will keep these as as repeating
  • 54:52sessions as we learn more as hopefully we
  • 54:55understand more about the booster for J&J,
  • 54:57or as we hear more about cancer,
  • 55:00people who care givers and
  • 55:01then they would be eligible.
  • 55:02'cause I sensed a lot of
  • 55:05questions around that.
  • 55:06As always,
  • 55:07please reach out to us as
  • 55:09cancer answers at yale.edu.