June 12, 2009


June 12, 2009


PARP Inhibitors Offer Promising Results

One of the hottest topics of last week's annual ASCO meeting was the use of PARP inhibitors, which stop cancer cells from repairing the damage caused by chemotherapy.
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Dr. Lyndsay Harris is the principal investigator on a Phase I clinical trial at Yale Cancer Center evaluating the combination of BSI-201, a PARP inhibitor, and Irinotecan for patients with advanced solid tumors.

New York Magazine Best Doctors

Congratulations to the 21 members of Yale Cancer Center who were honored in the June 15, 2009 Best Doctors issue of New York Magazine:  Masoud Azodi, MD, Edward Chu, MD, Richard Edelson, MD, Sukru Emre, MD, Kevin Kelly, DO, John Kveton, MD, David Leffell, MD, Walter Longo, MD, MBA, Pasquale Patrizio, MD, John Persing, MD, Richard Peschel, MD, PhD, Joseph Piepmeier, MD, Kenneth Roberts, MD, Clarence Sasaki, MD, Richard Stahl, MD, Lynn Tanoue, MD, Hugh Taylor, MD, J. Grant Thomson, MD,  Robert Udelsman, MD, MBA, Jeffrey Weinreb, MD, and Lynn Wilson, MD, MPH.

Pilot Grants Program

We are pleased to launch the 2009 Pilot Grants competition. These awards will support new innovative basic, translational, clinical, computational, and prevention/control cancer research.

Applications are due by July 15th.

New Fellows Welcomed

June brings an exciting transition in academic medical centers when a new group of fellows begins their rotations. We welcome the following physicians to our program:


Dan Landau, MD and Terri Parker, MD

Medical Oncology:

Susan Alsamarai, MD, Jaclyn Christine Flanigan, MD, Aleagia Mercer-Falkoff, MD, Krishna Gunturu, MD, and Jaykumar Thumar, MD

New Grand Rounds Format

Beginning this fall, the Yale Cancer Center Grand Rounds will be reformatted to broaden the appeal of the presentations. Each week will be split into two 20-minute segments focused on two of the following categories: basic sciences, clinical care, or population sciences. Participation in Grand Rounds will be an important component of cancer center membership.

Beginning on September 1st, Rounds will take place at noon in the Brady Auditorium.  Lunch will be served.

Smilow Update

Building Progress

430 construction workers are diligently working to complete different areas of the new hospital. The glass is in place in the front lobby, and a canopy will go up in the next two weeks to highlight the main entrance. Cabinetry is being moved into the basement and levels 1, 2, and 3, where the ceilings are also being finished. Installation of the exterior sidewalks and planters is also in progress.

Shared Resource Highlight

Rapid Case Ascertainment

The mission of the Rapid Case Ascertainment (RCA) Shared Resource is to provide services to population researchers at Yale Cancer Center, the State of Connecticut, and other institutions, building on the unique relationship with the Connecticut Tumor Registry. Some of the many services the RCA performs include timely identification of newly diagnosed cancer cases in Connecticut, obtaining and maintaining Institutional Review Board approvals, collecting pathology specimens from hospitals, and collecting other data as needed.

Rajni Mehta, MPH, Director

Recent Publications

Anaplastic oligoastrocytoma in Turcot syndrome.

Baehring J, Hui P, Piepmeier J, Bannykh SI.
J Neurooncol. 2009 Jun 4.

Ocular complications of cancer therapy: a primer for the ophthalmologist treating cancer patients.

Hazin R, Abuzetun JY, Daoud YJ, Abu-Khalaf MM.
Curr Opin Ophthalmol. 2009 Jun 1.

Genome-wide screen of promoter methylation identifies novel markers in melanoma.

Koga Y, Pelizzola M, Cheng E, Krauthammer M, Sznol M, Ariyan S, Narayan D, Molinaro AM, Halaban R, Weissman SM.
Genome Res. 2009 Jun 2.

Factors Related to the Use of Dietary Supplements by Cancer Survivors.

Ferrucci LM, McCorkle R, Smith T, Stein KD, Cartmel B.
J Altern Complement Med. 2009 Jun 2.

Topoisomerase II{alpha} Amplification Does Not Predict Benefit From Dose-Intense Cyclophosphamide, Doxorubicin, and Fluorouracil Therapy in HER2-Amplified Early Breast Cancer: Results of CALGB 8541/150013.

Harris LN, Broadwater G, Abu-Khalaf M, Cowan D, Thor AD, Budman D, Cirrincione CT, Berry DA, Winer EP, Hudis CA, Hayes DF, Friedman P, Ellis M, Dressler L.
J Clin Oncol. 2009 May 26.

Pluripotent factor lin-28 and its homologue lin-28b in epithelial ovarian cancer and their associations with disease outcomes and expression of let-7a and IGF-II.

Lu L, Katsaros D, Shaverdashvili K, Qian B, Wu Y, de la Longrais IA, Preti M, Menato G, Yu H.
Eur J Cancer. 2009 May 26.

NV-128, a novel isoflavone derivative, induces caspase-independent cell death through the Akt/mammalian target of rapamycin pathway.

Alvero AB, Montagna MK, Chen R, Kim KH, Kyungjin K, Visintin I, Fu HH, Brown D, Mor G.
Cancer. 2009 May 26.

YCC smilow

Inside Yale Cancer Center



The most recent issue of Advances focuses in on pancreatic cancer, including improved technology for diagnosing the disease, highlights from recent clinical trials, and surgical options for patients.


Each month Yale Cancer Center publishes a new issue of YaleCares, a supportive care newsletter. Edited by Thomas Quinn, APRN, each issue features an overview of a supportive oncology topic and links to additional resources.


Oncology Congress

Yale Cancer Center is one of the partners for the 5th annual Oncology Congress. Register now to take advantage of special reduced rates.


June 12; 1:00 PM

Molecular Virology Research Program Conference

Genetics Conference Room,

SHM I-116

A Biological Screen Identifies New Genes and Compounds Affecting SV40 Infection

Edward Goodwin, PhD

June 16; 8:30 AM

Yale Cancer Center
Grand Rounds

Fitkin Amphitheater

Adoptive T Cell Therapy:

A New Hope?

Cassian Yee, MD

June 16; 5:00 PM

Signal Transduction Research Conference

Genetics Conference Room,

SHM I-116

Integrative Bioinformatics Analysis across the Melanoma Genome, Transcriptome,

and Kinome

Michael Krauthammer, MD, PhD

June 23; 8:30 AM

Yale Cancer Center
Grand Rounds

Fitkin Amphitheater

Targeting the RAS Pathway

Frank McCormick, PhD

June 26; 7:00 AM

Yale ASCO Review 2009

The Anlyan Center


Please submit your recent publication and grant announcements to:

Renee Gaudette

Director, Public Affairs and Marketing