James B. Yu, MD, MHS

Professor of Therapeutic Radiology; Director, Prostate and Genitourinary Cancer Radiotherapy Program

Departments & Organizations

Therapeutic Radiology: Central Nervous System Radiotherapy | Prostate & Genitourinary Radiotherapy | Spine Radiosurgery

Brain Tumor Program

Center for Biomedical Data Science

Gamma Knife Center

Radiation Oncology

Radiobiology & Radiotherapy

Yale Cancer Center: Brain Tumor Program | COPPER Center | Prostate & Urologic Cancers Program | Radiobiology & Radiotherapy

Yale Medicine

Office of Cooperative Research


James Yu, MD, MHS, is the director of Yale Medicine’s Prostate & Genitourinary Cancer Radiotherapy Program. A radiation oncologist, Dr. Yu specializes in treating genitourinary cancers such as kidney, bladder and prostate, central nervous system cancers and cases requiring Gamma Knife stereotactic radiosurgery. 

“We treat our patients with state-of-the-art, evidence-based care that takes into account not just their medical condition, but their values and goals,” he says. “Using advanced technology, such as the Leksell Gamma Knife® Icon™, we can protect as much of the patient’s brain as possible.  This maximizes our patients’ ability to think and function. I tell patients that our treatments try to keep ‘you being you’ for as long as possible.”

An associate professor of therapeutic radiology at Yale School of Medicine, Dr. Yu also conducts research on ways to use radiotherapy treatments to improve outcomes for cancer patients. “We need to push the field ever forward and not be satisfied with merely prolonging survival,” says Dr. Yu. “I think radiosurgery will play a role in this. As systemic therapies improve and our ability to control microscopically disseminated disease improves, noninvasive ablative therapies will become ever more important.”

As a former Yale Center for Clinical Investigation scholar and member of the Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center at Yale, Dr. Yu’s research centers on the comparative effectiveness of new radiation technologies and how these new technologies are adopted nationally. Dr. Yu is currently a Senior Editor of the journal Practical Radiation Oncology, and is on the editorial boards of the Journal of Clinical Oncology, Journal of Clinical Oncology - Clinical Cancer Informatics, JNCI, JNCI-Cancer Spectrum, European Urology - Oncology, Journal of Surgical Oncology, and Oncology (Williston Park).

Education & Training

MHS Yale University, Masters of Health Science (2014)
MD University of Michigan Medical School (2004)
BS Yale University (1999)
Chief Resident Yale School of Medicine
Resident Yale New Haven Hospital
Intern California Pacific Medical Center, San Francisco, CA
Board Certification AB of Radiology, Radiation Oncology (2010)

Honors & Recognition

  • Cancer Prevention and Control Research PrizeYale Cancer Center (2017)

  • Population Research PrizeYale Cancer Center (2013)

  • Seattle Prostate Brachytherapy FellowAmerican Brachytherapy Society (2009)

  • Young Oncologist Essay AwardAmerican Radium Society (2008)

  • Research and Education Foundation Research GrantRadiological Society of North America (2008)

  • Roentgen Resident Research AwardRSNA (2008)

  • University of Michigan Medical School Commencement Class Speaker (2004)

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Contact Info

James B. Yu, MD, MHS
Patient Care Location
Yale Therapeutic RadiologySmilow Cancer Hospital at Yale New Haven
35 Park Street, Ste Lower Level

New Haven, CT 06511
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Office Location
Yale Therapeutic RadiologyHunter Building
15 York Street, Ste HRT 138

New Haven, CT 06510
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Mailing Address
Therapeutic RadiologyPO Box 208040
New Haven, CT 06520-8040

Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center at Yale