Roy S. Herbst, MD, PhD

Ensign Professor of Medicine (Medical Oncology) and Professor of Pharmacology; Chief of Medical Oncology, Yale Cancer Center and Smilow Cancer Hospital; Associate Director for Translational Research, Yale Cancer Center; Interim Director of Yale Center for Immuno-oncology, Yale Cancer Center

Research Interests

Lung Neoplasms; Medical Oncology; Thoracic Neoplasms; Clinical Trials, Phase I as Topic; Biomarkers, Pharmacological; Precision Medicine

Public Health Interests


Research Organizations

Internal Medicine: Medical Oncology: Subset Medical Oncology Faculty

Human and Translational Immunology Program

Yale Cancer Center: Developmental Therapeutics

Office of Cooperative Research

Research Summary

I am committed to maintaining Yale’s status as one of the world's top centers for cancer research and patient care, through innovative programs at the cutting edge of science and clinical practice. For example, we have a facility to investigate a patient's cancer at the molecular level giving us key molecular data that our oncologists use to pursue the most promising treatments for our patients as early as possible in the course of their disease.

I am the principal investigator for the innovative BATTLE clinical trial program for lung cancer, which uses molecular analysis of fresh tissue biopsies to help determine the best novel treatment in real time, and these results provide laboratory scientists the ability to explore and uncover potential resistance mechanisms in the clinic.

Specialized Terms: Early phase clinical trials; Biomarker studies; Personalized medicine for cancer treatment.

Selected Publications

Full List of PubMed Publications

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Contact Info

Roy S. Herbst, MD, PhD
Patient Care Location
Yale Cancer CenterYale New Haven Hospital
20 York Street, Ste North Pavilion 4

New Haven, CT 06510
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Mailing Address
Medical OncologyPO Box 208028
New Haven, CT 06520-8028