Sajid A Khan, MD, FACS

Assistant Professor of Surgery (Oncology)

Research Interests

Liver; Molecular Biology; Neoplasm Metastasis; Stomach Neoplasms; Colorectal Neoplasms; Cholangiocarcinoma; Carcinoma, Pancreatic Ductal; Gastrointestinal Stromal Tumors; Translational Medical Research; Metastasectomy

Research Organizations

Surgery: Surgical Oncology

Liver Cancer Program

Yale Cancer Center: Genomics, Genetics, and Epigenetics | Liver Cancer Program

Research Summary

Dr. Khan is an NIH-funded, surgeon-scientist who seeks to use modern molecular biology to improve our understanding and treatment of patients with gastrointestinal cancers. The Khan lab performs basic scientific investigation and translational research in close collaboration with other experts at the Yale Cancer Center in order to advance the field of oncology.  Our lab is currently studying the genetic basis underlying the mechanism of metastasis, in addition to the relationship between sex hormones, metabolite and protein expression on colon cancer patient outcomes. Furthermore, we perform clinical outcomes research in surgery for cancers which arise from the stomach, liver, pancreas, bile duct, small intestine, colon, appendix, and skin. Dr. Khan is also the Principal Investigator at Yale for a national clinical trial sponsored by the Southwest Oncology Group (SWOG) studying colorectal cancer chemoprevention.

Extensive Research Description

Dr. Khan is an NIH-funded, surgeon-scientist who seeks to use modern molecular biology to improve our understanding and treatment of patients with gastrointestinal cancers. The Khan lab performs basic scientific investigation and translational research in close collaboration with other experts at the Yale Cancer Center in order to advance the field of oncology.  Our lab is currently studying the genetic basis underlying the mechanism of metastasis, in addition to the relationship between sex hormones, metabolite and protein expression on colon cancer patient outcomes. Furthermore, we perform clinical outcomes research in surgery for cancers which arise from the stomach, liver, pancreas, bile duct, small intestine, colon, appendix, and skin. Dr. Khan is also the Principal Investigator at Yale for a national clinical trial sponsored by the Southwest Oncology Group (SWOG) studying colorectal cancer chemoprevention.


Selected Publications

  • Zhu R, Liu F, Grisotti G, Irizarry JP, Salem RR, Cha C, Johung K, Boffa D, Zhang Y, Khan SA. Utilization of adjuvant therapy in node positive gastric adenocarcinoma. Accepted for publication in Journal of Gastrointestinal Oncology 2018.
  • Blakaj A, Stein SS, Khan SA, Johung K. Review and current state of radiation therapy for locally advanced pancreatic adenocarcinoma. Accepted for publication at Journal of Gastrointestinal Oncology 2018.
  • Zhu R, Liu F, Grisotti G, Irizarry JP, Cha C, Johnson CH, Boffa DJ, Han D, Johung KL, Zhang Y, Khan SA. Distinctive Features of Gastrointestinal Stromal Tumors Arising from the Colon and Rectum. In press at Journal of Gastrointestinal Oncology 2018
  • Rattray NJ, Deziel NC, Wallach JD, Khan SA, Vasiliou V, Ioannidis JP, Johnson CH. Beyond genomics: understanding exposotypes through metabolomics. Human Genomics 2018.
  • Pen W, Zhu S, Qu K, Meeth K, Cheng J, He K, Ma H, Liao Y, Wen X, Roden C, Tobiasova Z, Wei Z, Zhao J, Liu J, Zheng J, Khan SA, Bosenberg M, Flavell R, Lu J. The DNA methylcytosine dioxygenase Tet2 sustains immunosuppressive function of tumor-infiltrating myeloid cells to promote melanoma progression. Immunity 2017.
  • Alkukhun A, Grisotti G, Salem RR, Cha C, Khan SA. Gastric volvulus after laparoscopic distal pancreatectomy and splenectomy: a case report of a rare post-operative complication. In press at American College of Surgeons Case Reviews in Surgery 2017.
  • Gao SJ, Park HS, Corso CD, Rutter CE, Khan SA, Johung KL. Post-operative radiotherapy is associated with improved survival in esophageal cancer with positive margins. In press at Journal of Gastrointestinal Oncology 2017.
  • Rubinstein JC, Majumdar SK, Laskin W, Lazaga F, Prasad ML, Carling T, Khan SA. Hyperparathyroidism-jaw tumor syndrome associated with large-scale 1q31 deletion. Journal of Endocrine Society 2017.
  • Kole AJ, Stahl JM, Park HS, Khan SA, Johung KL. Predictors of non-adherence to national comprehensive cancer network management guidelines for stage I anal canal cancer. Journal of National Comprehensive Cancer Network 2017.
  • Liu J, Chen Z, Wang N, Iacovino M, Cheng J, Roden C, Pen W, Khan SA, Chen S, Kyba M, Fan R, Guo S, Lu J. MicroRNA-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving VEGFA-mediated non-cell intrinsic mechanism. Blood 2017.
  • Khan SA, Zeng Z, Shia J, Paty P. EGFR Gene Amplification and KRAS Mutation Predict Response to Combination Targeted Therapy in Metastatic Colorectal Cancer. Pathology and Oncology Research. 2016
  • Khan SA, Morris M, Idrees K, Gimbel M, Rosenberg S, Zeng Z, Shia J, LaQuaglia M, Paty PB. Colorectal cancer in the very young: a comparative study of tumor markers, pathology and survival in early onset and adult onset patients. Journal of Pediatric Surgery, 2016
  • Zhu R, Grisotti G, Salem R, Khan SA. Pancreaticoduodenecotomy for Locally Advanced Early Onset Colon Cancer. World Journal of Surgical Oncology, 2016
  • Grisotti G, Khan SA. Management of Small Nonfunctional Pancreatic Neuroendocrine Tumor Molecular Cancer Therapeutics. Difficult Decisions in Hepatobiliary and Pancreatic Surgery – An Evidence Based Approach 2015
  • Wightman S, Uppal A, Pitroda S, Ganai S, Burnette B, Stack M, Oshima G, Khan SA, Huang X, Posner MC, Weichselbaum RR, Khodarev NN. Oncogenic CXCL10 signaling drives metastasis development and poor clinical outcome. British Journal of Cancer, 2015
  • Khan SA, Bank J, Choi E, Song D. Skin and Subcutaneous Tissue. Schwartz's Principles of Surgery, Tenth Edition, 2014.
  • Khan SA, Matthews JB. Intraoperative margin re-resection for colorectal liver metastases. Hepatobiliary Surgery and Nutrition 2013.
  • Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs.

    Lussier YA, Khodarev NN, Regan K, Corbin K, Li H, Ganai S, Khan SA, Gnerlich JL, Darga TE, Fan H, Karpenko O, Paty PB, Posner MC, Chmura SJ, Hellman S, Ferguson MK, Weichselbaum RR. Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs. PloS One 2012, 7:e50141.

  • Pitroda SP, Zhou T, Sweis RF, Filipo M, Labay E, Mauceri HJ, Beckett MA, Liang H, Perakis S, Khan SA, Darga T, Zhang W, Garcia JG, Khodarev NN, Weichselbaum RR. Tumor endothelial inflammatory gene expression predicts outcome in diverse human cancers. Public Library of Science (PLoS) One 2012.
  • Radiofrequency ablation of advanced head and neck cancer.

    Owen RP, Khan SA, Negassa A, Beitler JJ, Bello JA, Brook A, Farinhas J, Garg MK, Haigentz M, Miller TS, Hsu MS, Ravikumar TS, Shifteh K, Smith RV, Silver CE. Radiofrequency ablation of advanced head and neck cancer. Archives Of Otolaryngology--head & Neck Surgery 2011, 137:493-8.

  • MicroRNA expression characterizes oligometastasis(es).

    Lussier YA, Xing HR, Salama JK, Khodarev NN, Huang Y, Zhang Q, Khan SA, Yang X, Hasselle MD, Darga TE, Malik R, Fan H, Perakis S, Filippo M, Corbin K, Lee Y, Posner MC, Chmura SJ, Hellman S, Weichselbaum RR. MicroRNA expression characterizes oligometastasis(es). PloS One 2011, 6:e28650.

  • Improved testing for microsatellite instability in colorectal cancer using a simplified 3-marker assay.

    Esemuede I, Forslund A, Khan SA, Qin LX, Gimbel MI, Nash GM, Zeng Z, Rosenberg S, Shia J, Barany F, Paty PB. Improved testing for microsatellite instability in colorectal cancer using a simplified 3-marker assay. Annals Of Surgical Oncology 2010, 17:3370-8.

  • Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer.

    Cheng YW, Idrees K, Shattock R, Khan SA, Zeng Z, Brennan CW, Paty P, Barany F. Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer. International Journal Of Cancer. Journal International Du Cancer 2010, 127:568-77.

  • Khan SA, Idrees K, Forslund A, Zeng Z, Rosenberg S, Pincas H, Barany F, Offit K, LaQuaglia M, Paty PB. Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancer. Journal of Surgical Oncology 2008.
  • c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases.

    Zeng ZS, Weiser MR, Kuntz E, Chen CT, Khan SA, Forslund A, Nash GM, Gimbel M, Yamaguchi Y, Culliford AT, D'Alessio M, Barany F, Paty PB. c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases. Cancer Letters 2008, 265:258-69.

Edit this profile

Contact Info

Sajid A Khan, MD, FACS
Patient Care Locations
Yale Surgical OncologyTrumbull Care Center
5520 Park Avenue

Trumbull, CT 06611
View on map...
Yale Surgical OncologyBridgeport Hospital
267 Grant Street

Bridgeport, CT 06610
View on map...
Yale Surgical OncologySmilow Cancer Hospital at Yale New Haven
35 Park Street

New Haven, CT 06511
View on map...
Lab Location
Yale School of Medicine - Khan LabFarnam Memorial Building
310 Cedar Street

New Haven, CT 06510
View on map...
Office Location
Yale Surgical OncologyFarnam Memorial Building
310 Cedar Street, Ste 130

New Haven, CT 06510
View on map...
Mailing Address
Surgical OncologyPO BOX 208062
New Haven, CT 06520-8062

Curriculum Vitae

Khan Lab

Incidence trends for colorectal cancer in the United States