Robert J Homer, MD, PhD

Research Interests

Asthma; Education, Medical; Emphysema; Lung; Pathology; Pulmonary Fibrosis; Lung Diseases, Interstitial; Acute Lung Injury

Research Organizations

Pathology

Faculty Research

Skin Diseases Research Center, Yale

Yale Cancer Center

Office of Cooperative Research

Research Summary

(1). Models of inflammatory lung disease especially fibrosis.

(2) Miscellaneous interests include autopsy pathology, case reports, and quality assurance issues in pathology.

Specialized Terms: Lung pathology; Interstitial lung disease; immunopathology; Pathology of animal models of asthma; Pulmonary fibrosis; Acute lung injury; Emphysema

Extensive Research Description

(1) Pathology of asthma and other inflammatory lung diseases. I am the pathology co-principle investigator on several NIH grants relating to inflammatory lung disease including fibrosis, sepsis and infection. As such I select, perform, and analyze appropriate morphologic assays, primarily for light microscopy, but also for electron microscopy.

2) Miscellaneous interests include autopsy pathology, case reports, and quality assurance issues in pathology.

Full List of PubMed Publications

• Kelleher DW, Yaggi M, Homer R, Herzog EL, Ryu C: A rare presentation of pulmonary sarcoidosis as a solitary lung mass: a case report. J Med Case Rep. 2018 Apr 13; 2018 Apr 13. PMID: 29650028
• Yu G, Tzouvelekis A, Wang R, Herazo-Maya JD, Ibarra GH, Srivastava A, de Castro JPW, DeIuliis G, Ahangari F, Woolard T, Aurelien N, Arrojo E Drigo R, Gan Y, Graham M, Liu X, Homer RJ, Scanlan TS, Mannam P, Lee PJ, Herzog EL, Bianco AC, Kaminski N: Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. Nat Med. 2018 Jan; 2017 Dec 4. PMID: 29200204
• Rimm DL, Han G, Taube JM, Yi ES, Bridge JA, Flieder DB, Homer R, West WW, Wu H, Roden AC, Fujimoto J, Yu H, Anders R, Kowalewski A, Rivard C, Rehman J, Batenchuk C, Burns V, Hirsch FR, Wistuba II: A Prospective, Multi-institutional, Pathologist-Based Assessment of 4 Immunohistochemistry Assays for PD-L1 Expression in Non-Small Cell Lung Cancer. JAMA Oncol. 2017 Aug 1. PMID: 28278348
• Homer R, Lederer DJ: Diagnosing idiopathic pulmonary fibrosis without a lung biopsy: honeycombing not required. Thorax. 2017 May; 2017 Mar 9. PMID: 28280234
• Uraki R, Hwang J, Jurado KA, Householder S, Yockey LJ, Hastings AK, Homer RJ, Iwasaki A, Fikrig E: Zika virus causes testicular atrophy. Sci Adv. 2017 Feb; 2017 Feb 22. PMID: 28261663
• Tzouvelekis A, Yu G, Lino Cardenas CL, Herazo-Maya JD, Wang R, Woolard T, Zhang Y, Sakamoto K, Lee H, Yi JS, DeIuliis G, Xylourgidis N, Ahangari F, Lee PJ, Aidinis V, Herzog EL, Homer R, Bennett AM, Kaminski N: SH2 Domain-Containing Phosphatase-2 Is a Novel Antifibrotic Regulator in Pulmonary Fibrosis. Am J Respir Crit Care Med. 2017 Feb 15. PMID: 27736153
• Ryu C, Herzog EL, Pan H, Homer R, Gulati M: Upper Airway Obstruction Requiring Emergent Tracheostomy Secondary to Laryngeal Sarcoidosis: A Case Report. Am J Case Rep. 2017 Feb 13; 2017 Feb 13. PMID: 28190872
• Vukmirovic M, Herazo-Maya JD, Blackmon J, Skodric-Trifunovic V, Jovanovic D, Pavlovic S, Stojsic J, Zeljkovic V, Yan X, Homer R, Stefanovic B, Kaminski N: Identification and validation of differentially expressed transcripts by RNA-sequencing of formalin-fixed, paraffin-embedded (FFPE) lung tissue from patients with Idiopathic Pulmonary Fibrosis. BMC Pulm Med. 2017 Jan 12; 2017 Jan 12. PMID: 28081703
• Golestani R, Razavian M, Ye Y, Zhang J, Jung JJ, Toczek J, Gona K, Kim HY, Elias JA, Lee CG, Homer RJ, Sadeghi MM: Matrix Metalloproteinase-Targeted Imaging of Lung Inflammation and Remodeling. J Nucl Med. 2017 Jan; 2016 Jul 28. PMID: 27469361
• Peng X, Moore M, Mathur A, Zhou Y, Sun H, Gan Y, Herazo-Maya JD, Kaminski N, Hu X, Pan H, Ryu C, Osafo-Addo A, Homer RJ, Feghali-Bostwick C, Fares WH, Gulati M, Hu B, Lee CG, Elias JA, Herzog EL: Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage migration and enhances mammalian lung fibrosis. FASEB J. 2016 Dec; 2016 Sep 8. PMID: 27609773
• Sureshbabu A, Syed M, Das P, Janér C, Pryhuber G, Rahman A, Andersson S, Homer RJ, Bhandari V: Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice. Am J Respir Cell Mol Biol. 2016 Nov. PMID: 27374190
• Rimm D, Han G, Taube JM, Yi ES, Bridge JA, Flieder DB, Homer R, West WW, Wu H, Roden AC, Fujimoto J, Yu H, Anders R, Kowalewski A, Rivard C, Rehman J, Hirsch F, Wistuba II: ORAL01.01: A Prospective, Multi-Institutional Assessment of Four Assays for PD-L1 Expression in NSCLC by Immunohistochemistry: Topic: Pathology. J Thorac Oncol. 2016 Nov; 2016 Oct 28. PMID: 27969440
• Forloni M, Gupta R, Nagarajan A, Sun LS, Dong Y, Pirazzoli V, Toki M, Wurtz A, Melnick MA, Kobayashi S, Homer RJ, Rimm DL, Gettinger SJ, Politi K, Dogra SK, Wajapeyee N: Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells. Cell Rep. 2016 Jul 12; 2016 Jun 23. PMID: 27346347
• Ryu C, Homer RJ, Herzog EL: The Airway in Idiopathic Pulmonary Fibrosis: Protecting the Lung or Promoting Disease? Am J Respir Crit Care Med. 2016 May 15. PMID: 27174477
• Bramley K, Pisani MA, Murphy TE, Araujo KL, Homer RJ, Puchalski JT: Endobronchial Ultrasound-Guided Cautery-Assisted Transbronchial Forceps Biopsies: Safety and Sensitivity Relative to Transbronchial Needle Aspiration. Ann Thorac Surg. 2016 May; 2016 Feb 22. PMID: 26912301
• Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, Staeheli P, Iwasaki A: Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science. 2016 Apr 22. PMID: 27102485
• Bruscia EM, Zhang PX, Barone C, Scholte BJ, Homer R, Krause DS, Egan ME: Increased susceptibility of Cftr-/- mice to LPS-induced lung remodeling. Am J Physiol Lung Cell Mol Physiol. 2016 Apr 15; 2016 Feb 5. PMID: 26851259
• Syed MA, Choo-Wing R, Homer RJ, Bhandari V: Role of Nitric Oxide Isoforms in Vascular and Alveolar Development and Lung Injury in Vascular Endothelial Growth Factor Overexpressing Neonatal Mice Lungs. PLoS One. 2016; 2016 Jan 22. PMID: 26799210
• Ramaswamy A, Homer R, Killam J, Pisani MA, Murphy TE, Araujo K, Puchalski J: Comparison of Transbronchial and Cryobiopsies in Evaluation of Diffuse Parenchymal Lung Disease. J Bronchology Interv Pulmonol. 2016 Jan. PMID: 26705007
• Homer RJ: Pathologists' staging of multiple foci of lung cancer: poor concordance in absence of dramatic histologic or molecular differences. Am J Clin Pathol. 2015 May. PMID: 25873504
• Sureshbabu A, Syed MA, Boddupalli CS, Dhodapkar MV, Homer RJ, Minoo P, Bhandari V: Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung. Respir Res. 2015 Jan 16; 2015 Jan 16. PMID: 25591994
• Zhang X, Shan P, Homer R, Zhang Y, Petrache I, Mannam P, Lee PJ: Cathepsin E promotes pulmonary emphysema via mitochondrial fission. Am J Pathol. 2014 Oct. PMID: 25239563
• Lafferty EI, Flaczyk A, Angers I, Homer R, d'Hennezel E, Malo D, Piccirillo CA, Vidal SM, Qureshi ST: An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection. Genes Immun. 2014 Jul-Aug; 2014 May 22. PMID: 24848930
• Zhou Y, Peng H, Sun H, Peng X, Tang C, Gan Y, Chen X, Mathur A, Hu B, Slade MD, Montgomery RR, Shaw AC, Homer RJ, White ES, Lee CM, Moore MW, Gulati M, Lee CG, Elias JA, Herzog EL: Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in Mammalian lung fibrosis. Sci Transl Med. 2014 Jun 11. PMID: 24920662
• Peng X, Moore MW, Peng H, Sun H, Gan Y, Homer RJ, Herzog EL: CD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-β1 exposed murine lung. Front Pharmacol. 2014; 2014 May 16. PMID: 24904415
• Cai G, Wong R, Chhieng D, Levy GH, Gettinger SN, Herbst RS, Puchalski JT, Homer RJ, Hui P: Identification of EGFR mutation, KRAS mutation, and ALK gene rearrangement in cytological specimens of primary and metastatic lung adenocarcinoma. Cancer Cytopathol. 2013 Sep; 2013 Mar 12. PMID: 23495083
• Jamieson AM, Pasman L, Yu S, Gamradt P, Homer RJ, Decker T, Medzhitov R: Role of tissue protection in lethal respiratory viral-bacterial coinfection. Science. 2013 Jun 7; 2013 Apr 25. PMID: 23618765
• Choo-Wing R, Syed MA, Harijith A, Bowen B, Pryhuber G, Janér C, Andersson S, Homer RJ, Bhandari V: Hyperoxia and interferon-γ-induced injury in developing lungs occur via cyclooxygenase-2 and the endoplasmic reticulum stress-dependent pathway. Am J Respir Cell Mol Biol. 2013 Jun. PMID: 23470621
• Sun H, Choo-Wing R, Sureshbabu A, Fan J, Leng L, Yu S, Jiang D, Noble P, Homer RJ, Bucala R, Bhandari V: A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung. PLoS One. 2013; 2013 Apr 29. PMID: 23637753
• Cho WK, Lee CM, Kang MJ, Huang Y, Giordano FJ, Lee PJ, Trow TK, Homer RJ, Sessa WC, Elias JA, Lee CG: IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2013 Jan 15; 2012 Nov 2. PMID: 23125252
• Reilkoff RA, Peng H, Murray LA, Peng X, Russell T, Montgomery R, Feghali-Bostwick C, Shaw A, Homer RJ, Gulati M, Mathur A, Elias JA, Herzog EL: Semaphorin 7a+ regulatory T cells are associated with progressive idiopathic pulmonary fibrosis and are implicated in transforming growth factor-β1-induced pulmonary fibrosis. Am J Respir Crit Care Med. 2013 Jan 15; 2012 Dec 6. PMID: 23220917
• Bhandari V, Choo-Wing R, Harijith A, Sun H, Syed MA, Homer RJ, Elias JA: Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2. Am J Respir Cell Mol Biol. 2012 May; 2012 Jan 6. PMID: 22227562
• Anagnostou VK, Dimou AT, Botsis T, Killiam EJ, Gustavson MD, Homer RJ, Boffa D, Zolota V, Dougenis D, Tanoue L, Gettinger SN, Detterbeck FC, Syrigos KN, Bepler G, Rimm DL: Molecular classification of nonsmall cell lung cancer using a 4-protein quantitative assay. Cancer. 2012 Mar 15; 2011 Aug 25. PMID: 22009766
• Antin-Ozerkis D, Rubinowitz A, Evans J, Homer RJ, Matthay RA: Interstitial lung disease in the connective tissue diseases. Clin Chest Med. 2012 Mar. PMID: 22365251
• Detterbeck FC, Homer RJ: Approach to the ground-glass nodule. Clin Chest Med. 2011 Dec; 2011 Oct 2. PMID: 22054887
• Mitchell C, Provost K, Niu N, Homer R, Cohn L: IFN-γ acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease. J Immunol. 2011 Oct 1; 2011 Aug 26. PMID: 21873527
• Mijares LA, Wangdi T, Sokol C, Homer R, Medzhitov R, Kazmierczak BI: Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway. J Immunol. 2011 Jun 15; 2011 May 13. PMID: 21572023
• Matsuura H, Hartl D, Kang MJ, Dela Cruz CS, Koller B, Chupp GL, Homer RJ, Zhou Y, Cho WK, Elias JA, Lee CG: Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema. Am J Respir Cell Mol Biol. 2011 Jun; 2010 Jul 23. PMID: 20656949
• Homer RJ, Elias JA, Lee CG, Herzog E: Modern concepts on the role of inflammation in pulmonary fibrosis. Arch Pathol Lab Med. 2011 Jun. PMID: 21631273
• Ma B, Dela Cruz CS, Hartl D, Kang MJ, Takyar S, Homer RJ, Lee CG, Elias JA: RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism. Am J Respir Crit Care Med. 2011 May 15; 2011 Jan 28. PMID: 21278304
• Harijith A, Choo-Wing R, Cataltepe S, Yasumatsu R, Aghai ZH, Janér J, Andersson S, Homer RJ, Bhandari V: A role for matrix metalloproteinase 9 in IFNγ-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia. Am J Respir Cell Mol Biol. 2011 May; 2011 Jan 7. PMID: 21216975
• Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC: Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. J Exp Med. 2010 Nov 22; 2010 Oct 25. PMID: 20975041
• Homer RJ, Herzog EL: Recent advances in pulmonary fibrosis: implications for scleroderma. Curr Opin Rheumatol. 2010 Nov. PMID: 20693906
• Antin-Ozerkis D, Evans J, Rubinowitz A, Homer RJ, Matthay RA: Pulmonary manifestations of rheumatoid arthritis. Clin Chest Med. 2010 Sep. PMID: 20692539
• Anagnostou VK, Lowery FJ, Zolota V, Tzelepi V, Gopinath A, Liceaga C, Panagopoulos N, Frangia K, Tanoue L, Boffa D, Gettinger S, Detterbeck F, Homer RJ, Dougenis D, Rimm DL, Syrigos KN: High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology. BMC Cancer. 2010 May 9; 2010 May 9. PMID: 20459695
• Trang P, Medina PP, Wiggins JF, Ruffino L, Kelnar K, Omotola M, Homer R, Brown D, Bader AG, Weidhaas JB, Slack FJ: Regression of murine lung tumors by the let-7 microRNA. Oncogene. 2010 Mar 18; 2009 Dec 7. PMID: 19966857
• Mathai SK, Rubinowitz AN, Homer RJ, Detterbeck F, Herzog EL: Of lungs, lipids, and lollipops. Chest. 2009 Nov. PMID: 19892683
• Niu N, Laufer T, Homer RJ, Cohn L: Cutting edge: Limiting MHC class II expression to dendritic cells alters the ability to develop Th2- dependent allergic airway inflammation. J Immunol. 2009 Aug 1; 2009 Jul 13. PMID: 19596982
• Anagnostou VK, Bepler G, Syrigos KN, Tanoue L, Gettinger S, Homer RJ, Boffa D, Detterbeck F, Rimm DL: High expression of mammalian target of rapamycin is associated with better outcome for patients with early stage lung adenocarcinoma. Clin Cancer Res. 2009 Jun 15; 2009 Jun 9. PMID: 19509151
• Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE: A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proc Natl Acad Sci U S A. 2009 Jun 2; 2009 May 19. PMID: 19458046
• Trow TK, Morris DG, Miller CR, Homer RJ: Granulomatous bronchiolitis of Crohn's disease successfully treated with inhaled budesonide. Thorax. 2009 Jun. PMID: 19478123
• Lee CG, Hartl D, Lee GR, Koller B, Matsuura H, Da Silva CA, Sohn MH, Cohn L, Homer RJ, Kozhich AA, Humbles A, Kearley J, Coyle A, Chupp G, Reed J, Flavell RA, Elias JA: Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. J Exp Med. 2009 May 11; 2009 May 4. PMID: 19414556
• Anagnostou VK, Syrigos KN, Bepler G, Homer RJ, Rimm DL: Thyroid transcription factor 1 is an independent prognostic factor for patients with stage I lung adenocarcinoma. J Clin Oncol. 2009 Jan 10; 2008 Dec 8. PMID: 19064983
• Lee CG, Hartl D, Matsuura H, Dunlop FM, Scotney PD, Fabri LJ, Nash AD, Chen NY, Tang CY, Chen Q, Homer RJ, Baca M, Elias JA: Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production. Am J Respir Cell Mol Biol. 2008 Dec; 2008 Jul 10. PMID: 18617680
• Hartl D, He CH, Koller B, Da Silva CA, Homer R, Lee CG, Elias JA: Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells. J Biol Chem. 2008 Nov 28; 2008 Sep 29. PMID: 18824549
• Chin LJ, Ratner E, Leng S, Zhai R, Nallur S, Babar I, Muller RU, Straka E, Su L, Burki EA, Crowell RE, Patel R, Kulkarni T, Homer R, Zelterman D, Kidd KK, Zhu Y, Christiani DC, Belinsky SA, Slack FJ, Weidhaas JB: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Res. 2008 Oct 15. PMID: 18922928
• Bhandari V, Choo-Wing R, Lee CG, Yusuf K, Nedrelow JH, Ambalavanan N, Malkus H, Homer RJ, Elias JA: Developmental regulation of NO-mediated VEGF-induced effects in the lung. Am J Respir Cell Mol Biol. 2008 Oct; 2008 Apr 25. PMID: 18441284
• Rubinowitz AN, Moon M, Homer R: A 34-year-old man presenting with gradual onset of shortness of breath and interstitial lung disease. Chest. 2008 Apr. PMID: 18398129
• Yamasaki M, Kang HR, Homer RJ, Chapoval SP, Cho SJ, Lee BJ, Elias JA, Lee CG: P21 regulates TGF-beta1-induced pulmonary responses via a TNF-alpha-signaling pathway. Am J Respir Cell Mol Biol. 2008 Mar; 2007 Oct 11. PMID: 17932374
• Zhou J, Matsuoka M, Cantor H, Homer R, Enelow RI: Cutting edge: engagement of NKG2A on CD8+ effector T cells limits immunopathology in influenza pneumonia. J Immunol. 2008 Jan 1. PMID: 18096998
• Chapoval SP, Al-Garawi A, Lora JM, Strickland I, Ma B, Lee PJ, Homer RJ, Ghosh S, Coyle AJ, Elias JA: Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13. J Immunol. 2007 Nov 15. PMID: 17982094
• Kenney B, Dotto J, Homer R, Shafi N, Davydova L: Primary malignant melanoma of the transverse colon: report of a case and review of the literature. Int J Surg Pathol. 2007 Oct. PMID: 17913951
• Choo-Wing R, Nedrelow JH, Homer RJ, Elias JA, Bhandari V: Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 2007 Mar 30. PMID: 17400600
• Kenney B, Pinto M, Homer R: Benign pulmonary epithelial inclusions within the pleura: a case report. Diagn Pathol. 2007 Jun 29; 2007 Jun 29. PMID: 17603877
• Kang HR, Lee CG, Homer RJ, Elias JA: Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis. J Exp Med. 2007 May 14; 2007 May 7. PMID: 17485510
• Bhandari V, Choo-Wing R, Homer RJ, Elias JA: Increased hyperoxia-induced mortality and acute lung injury in IL-13 null mice. J Immunol. 2007 Apr 15. PMID: 17404281
• Niu N, Le Goff MK, Li F, Rahman M, Homer RJ, Cohn L: A novel pathway that regulates inflammatory disease in the respiratory tract. J Immunol. 2007 Mar 15. PMID: 17339484
• Kang HR, Cho SJ, Lee CG, Homer RJ, Elias JA: Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12. J Biol Chem. 2007 Mar 9; 2007 Jan 5. PMID: 17209037
• Kang MJ, Homer RJ, Gallo A, Lee CG, Crothers KA, Cho SJ, Rochester C, Cain H, Chupp G, Yoon HJ, Elias JA: IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. J Immunol. 2007 Feb 1. PMID: 17237446
• Temann UA, Laouar Y, Eynon EE, Homer R, Flavell RA: IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells. Int Immunol. 2007 Jan; 2006 Nov 13. PMID: 17101709
• Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA: Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med. 2006 Nov; 2006 Nov 5. PMID: 17086189
• Khazeni N, Homer RJ, Rubinowitz AN, Chupp GL: Massive cavitary pulmonary rheumatoid nodules in a patient with HIV. Eur Respir J. 2006 Oct. PMID: 17012633
• Homer RJ, Zhu Z, Cohn L, Lee CG, White WI, Chen S, Elias JA: Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 2006 Mar 23. PMID: 16556727
• Kang MJ, Lee CG, Cho SJ, Homer RJ, Elias JA: IFN-gamma-dependent DNA injury and/or apoptosis are critical in cigarette smoke-induced murine emphysema. Proc Am Thorac Soc. 2006 Aug. PMID: 16921135
• Elias JA, Kang MJ, Crothers K, Homer R, Lee CG: State of the art. Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice. Proc Am Thorac Soc. 2006 Aug. PMID: 16921126
• Lee CG, Cho S, Homer RJ, Elias JA: Genetic control of transforming growth factor-beta1-induced emphysema and fibrosis in the murine lung. Proc Am Thorac Soc. 2006 Aug. PMID: 16921114
• Bhandari V, Choo-Wing R, Chapoval SP, Lee CG, Tang C, Kim YK, Ma B, Baluk P, Lin MI, McDonald DM, Homer RJ, Sessa WC, Elias JA: Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proc Natl Acad Sci U S A. 2006 Jul 18; 2006 Jul 10. PMID: 16832062
• Lee CG, Kang HR, Homer RJ, Chupp G, Elias JA: Transgenic modeling of transforming growth factor-beta(1): role of apoptosis in fibrosis and alveolar remodeling. Proc Am Thorac Soc. 2006 Jul. PMID: 16799085
• Ma B, Blackburn MR, Lee CG, Homer RJ, Liu W, Flavell RA, Boyden L, Lifton RP, Sun CX, Young HW, Elias JA: Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis. J Clin Invest. 2006 May. PMID: 16670768
• Ma B, Liu W, Homer RJ, Lee PJ, Coyle AJ, Lora JM, Lee CG, Elias JA: Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2006 Apr 15. PMID: 16585593
• Cho SJ, Kang MJ, Homer RJ, Kang HR, Zhang X, Lee PJ, Elias JA, Lee CG: Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling. J Biol Chem. 2006 Mar 24; 2006 Jan 26. PMID: 16439363
• Lee PJ, Zhang X, Shan P, Ma B, Lee CG, Homer RJ, Zhu Z, Rincon M, Mossman BT, Elias JA: ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. J Clin Invest. 2006 Jan; 2005 Dec 22. PMID: 16374521
• Ma B, Kang MJ, Lee CG, Chapoval S, Liu W, Chen Q, Coyle AJ, Lora JM, Picarella D, Homer RJ, Elias JA: Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema. J Clin Invest. 2005 Dec; 2005 Nov 10. PMID: 16284650
• Noble PW, Tanoue L, Homer R: Case study review. Chest. 2005 Nov. PMID: 16304245
• Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, Homer RJ, Goldstein DR, Bucala R, Lee PJ, Medzhitov R, Noble PW: Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med. 2005 Nov; 2005 Oct 23. PMID: 16244651
• Zhang X, Shan P, Qureshi S, Homer R, Medzhitov R, Noble PW, Lee PJ: Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. J Immunol. 2005 Oct 15. PMID: 16210584
• Elias JA, Homer RJ, Hamid Q, Lee CG: Chitinases and chitinase-like proteins in T(H)2 inflammation and asthma. J Allergy Clin Immunol. 2005 Sep. PMID: 16159614
• Noble PW, Homer RJ: Back to the future: historical perspective on the pathogenesis of idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 2005 Aug. PMID: 16024580
• Zheng T, Kang MJ, Crothers K, Zhu Z, Liu W, Lee CG, Rabach LA, Chapman HA, Homer RJ, Aldous D, De Sanctis GT, Underwood S, Graupe M, Flavell RA, Schmidt JA, Elias JA: Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. J Immunol. 2005 Jun 15. PMID: 15944319
• He CH, Waxman AB, Lee CG, Link H, Rabach ME, Ma B, Chen Q, Zhu Z, Zhong M, Nakayama K, Nakayama KI, Homer R, Elias JA: Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury. J Clin Invest. 2005 Apr. PMID: 15841185
• Chen Q, Rabach L, Noble P, Zheng T, Lee CG, Homer RJ, Elias JA: IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2005 Feb 15. PMID: 15699166
• Homer RJ, Elias JA: Airway remodeling in asthma: therapeutic implications of mechanisms. Physiology (Bethesda). 2005 Feb. PMID: 15653837
• Noble PW, Homer RJ: Idiopathic pulmonary fibrosis: new insights into pathogenesis. Clin Chest Med. 2004 Dec. PMID: 15564020
• Kawikova I, Paliwal V, Szczepanik M, Itakura A, Fukui M, Campos RA, Geba GP, Homer RJ, Iliopoulou BP, Pober JS, Tsuji RF, Askenase PW: Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma. Immunology. 2004 Oct. PMID: 15379984
• Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM, Elias JA: Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med. 2004 Oct; 2004 Sep 19. PMID: 15378055
• Lee CG, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, Yehualaeshet T, Lu B, Flavell RA, Milbrandt J, Homer RJ, Elias JA: Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med. 2004 Aug 2. PMID: 15289506
• Jiang D, Liang J, Hodge J, Lu B, Zhu Z, Yu S, Fan J, Gao Y, Yin Z, Homer R, Gerard C, Noble PW: Regulation of pulmonary fibrosis by chemokine receptor CXCR3. J Clin Invest. 2004 Jul. PMID: 15254596
• Zhu Z, Zheng T, Homer RJ, Kim YK, Chen NY, Cohn L, Hamid Q, Elias JA: Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science. 2004 Jun 11. PMID: 15192232
• Ma B, Zhu Z, Homer RJ, Gerard C, Strieter R, Elias JA: The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2004 Feb 1. PMID: 14734772
• Wang J, Chen Q, Corne J, Zhu Z, Lee CG, Bhandari V, Homer RJ, Elias JA: Pulmonary expression of leukemia inhibitory factor induces B cell hyperplasia and confers protection in hyperoxia. J Biol Chem. 2003 Aug 15; 2003 Jun 2. PMID: 12782633
• Zheng T, Zhu Z, Liu W, Lee CG, Chen Q, Homer RJ, Elias JA: Cytokine regulation of IL-13Ralpha2 and IL-13Ralpha1 in vivo and in vitro. J Allergy Clin Immunol. 2003 Apr. PMID: 12704349
• Zhu Z, Enhorning G, Zheng T, Chen Q, Chen NY, Homer R, Elias JA: Interleukin-13 induces surfactant function abnormality in the murine lung. Chest. 2003 Mar. PMID: 12628990
• Elias JA, Zheng T, Lee CG, Homer RJ, Chen Q, Ma B, Blackburn M, Zhu Z: Transgenic modeling of interleukin-13 in the lung. Chest. 2003 Mar. PMID: 12628967
• Elias JA, Lee CG, Zheng T, Ma B, Homer RJ, Zhu Z: New insights into the pathogenesis of asthma. J Clin Invest. 2003 Feb. PMID: 12569150
• Whittaker L, Niu N, Temann UA, Stoddard A, Flavell RA, Ray A, Homer RJ, Cohn L: Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9. Am J Respir Cell Mol Biol. 2002 Nov. PMID: 12397019
• Lee CG, Homer RJ, Cohn L, Link H, Jung S, Craft JE, Graham BS, Johnson TR, Elias JA: Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways. J Biol Chem. 2002 Sep 20; 2002 Jul 9. PMID: 12107190
• Lanone S, Zheng T, Zhu Z, Liu W, Lee CG, Ma B, Chen Q, Homer RJ, Wang J, Rabach LA, Rabach ME, Shipley JM, Shapiro SD, Senior RM, Elias JA: Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J Clin Invest. 2002 Aug. PMID: 12189240
• Homer RJ, Zheng T, Chupp G, He S, Zhu Z, Chen Q, Ma B, Hite RD, Gobran LI, Rooney SA, Elias JA: Pulmonary type II cell hypertrophy and pulmonary lipoproteinosis are features of chronic IL-13 exposure. Am J Physiol Lung Cell Mol Physiol. 2002 Jul. PMID: 12060560
• Zhu Z, Zheng T, Lee CG, Homer RJ, Elias JA: Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling. Semin Cell Dev Biol. 2002 Apr. PMID: 12127145
• Zhu Z, Ma B, Zheng T, Homer RJ, Lee CG, Charo IF, Noble P, Elias JA: IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2002 Mar 15. PMID: 11884467
• Cohn L, Whittaker L, Niu N, Homer RJ: Cytokine regulation of mucus production in a model of allergic asthma. Novartis Found Symp. 2002. PMID: 12568496
• Zhu Z, Lee CG, Zheng T, Chupp G, Wang J, Homer RJ, Noble PW, Hamid Q, Elias JA: Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice. Am J Respir Crit Care Med. 2001 Nov 15. PMID: 11734470
• Zheng T, Zhu Z, Wang J, Homer RJ, Elias JA: IL-11: insights in asthma from overexpression transgenic modeling. J Allergy Clin Immunol. 2001 Oct. PMID: 11590369
• Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, Shipley JM, Gotwals P, Noble P, Chen Q, Senior RM, Elias JA: Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med. 2001 Sep 17. PMID: 11560996
• Zhu Z, Ma B, Homer RJ, Zheng T, Elias JA: Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice. J Biol Chem. 2001 Jul 6; 2001 Apr 30. PMID: 11331286
• Cohn L, Herrick C, Niu N, Homer R, Bottomly K: IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation. J Immunol. 2001 Feb 15. PMID: 11160342
• Wang Z, Zheng T, Zhu Z, Homer RJ, Riese RJ, Chapman HA Jr, Shapiro SD, Elias JA: Interferon gamma induction of pulmonary emphysema in the adult murine lung. J Exp Med. 2000 Dec 4. PMID: 11104801
• Zheng T, Zhu Z, Wang Z, Homer RJ, Ma B, Riese RJ Jr, Chapman HA Jr, Shapiro SD, Elias JA: Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J Clin Invest. 2000 Nov. PMID: 11067861
• Wang J, Homer RJ, Chen Q, Elias JA: Endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2 inflammation. J Immunol. 2000 Oct 1. PMID: 11034416
• Corne J, Chupp G, Lee CG, Homer RJ, Zhu Z, Chen Q, Ma B, Du Y, Roux F, McArdle J, Waxman AB, Elias JA: IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury. J Clin Invest. 2000 Sep. PMID: 10995789
• Wang J, Homer RJ, Hong L, Cohn L, Lee CG, Jung S, Elias JA: IL-11 selectively inhibits aeroallergen-induced pulmonary eosinophilia and Th2 cytokine production. J Immunol. 2000 Aug 15. PMID: 10925310
• Jain D, Sarode VR, Abdul-Karim FW, Homer R, Robert ME: Evidence for the neoplastic transformation of Von-Meyenburg complexes. Am J Surg Pathol. 2000 Aug. PMID: 10935654
• Powsner SM, Costa J, Homer RJ: Clinicians are from Mars and pathologists are from Venus. Arch Pathol Lab Med. 2000 Jul. PMID: 10888781
• Homer RJ, Elias JA: Consequences of long-term inflammation. Airway remodeling. Clin Chest Med. 2000 Jun. PMID: 10907592
• Ward NS, Waxman AB, Homer RJ, Mantell LL, Einarsson O, Du Y, Elias JA: Interleukin-6-induced protection in hyperoxic acute lung injury. Am J Respir Cell Mol Biol. 2000 May. PMID: 10783124
• Cohn L, Homer RJ, Niu N, Bottomly K: T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production. J Exp Med. 1999 Nov 1. PMID: 10544202
• Zhang DH, Yang L, Cohn L, Parkyn L, Homer R, Ray P, Ray A: Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Immunity. 1999 Oct. PMID: 10549629
• Elias JA, Zhu Z, Chupp G, Homer RJ: Airway remodeling in asthma. J Clin Invest. 1999 Oct. PMID: 10525034
• Waxman AB, Einarsson O, Seres T, Knickelbein RG, Homer R, Warshaw JB, Johnston R, Elias JA: Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. Chest. 1999 Jul. PMID: 10424559
• Bromberg ME, Sundaram R, Homer RJ, Garen A, Konigsberg WH: Role of tissue factor in metastasis: functions of the cytoplasmic and extracellular domains of the molecule. Thromb Haemost. 1999 Jul. PMID: 10456459
• Cohn L, Homer RJ, MacLeod H, Mohrs M, Brombacher F, Bottomly K: Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. J Immunol. 1999 May 15. PMID: 10229862
• Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, Zhang Y, Elias JA: Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest. 1999 Mar. PMID: 10079098
• Homer RJ: Antineutrophil cytoplasmic antibodies as markers for systemic autoimmune disease. Clin Chest Med. 1998 Dec. PMID: 9917957
• Yang L, Cohn L, Zhang DH, Homer R, Ray A, Ray P: Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation. J Exp Med. 1998 Nov 2. PMID: 9802985
• Waxman AB, Einarsson O, Seres T, Knickelbein RG, Warshaw JB, Johnston R, Homer RJ, Elias JA: Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. J Clin Invest. 1998 May 1. PMID: 9576762
• Cohn L, Homer RJ, Marinov A, Rankin J, Bottomly K: Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J Exp Med. 1997 Nov 17. PMID: 9362533
• Ray P, Tang W, Wang P, Homer R, Kuhn C 3rd, Flavell RA, Elias JA: Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes. J Clin Invest. 1997 Nov 15. PMID: 9366564
• Trawick D, Kotch A, Matthay R, Homer RJ: Eosinophilic pneumonia as a presentation of occult chronic granulomatous disease. Eur Respir J. 1997 Sep. PMID: 9311521
• Redlich CA, Karol MH, Graham C, Homer RJ, Holm CT, Wirth JA, Cullen MR: Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate. Scand J Work Environ Health. 1997 Jun. PMID: 9243734
• Tang W, Geba GP, Zheng T, Ray P, Homer RJ, Kuhn C 3rd, Flavell RA, Elias JA: Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction. J Clin Invest. 1996 Dec 15. PMID: 8981933
• Redlich CA, Homer RJ, Smith BR, Wirth JA, Cullen MR: Immunologic responses to isocyanates in sensitized asthmatic subjects. Chest. 1996 Mar. PMID: 8598159
• Homer RJ, Khoo L, Smith GJ: Diffuse panbronchiolitis in a Hispanic man with travel history to Japan. Chest. 1995 Apr. PMID: 7705137
• Azrin MA, Ling FS, Chen Q, Pawashe A, Migliaccio F, Homer R, Todd M, Ezekowitz MD: Preparation, characterization, and evaluation of a monoclonal antibody against the rabbit platelet glycoprotein IIb/IIIa in an experimental angioplasty model. Circ Res. 1994 Aug. PMID: 8033340
• Homer RJ, Mamalaki C, Kioussis D, Flavell RA: T cell unresponsiveness correlates with quantitative TCR levels in a transgenic model. Int Immunol. 1993 Dec. PMID: 7906139

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