Decoding the Epigenome: Comparative Analysis of Uterine Leiomyosarcoma and Leiomyoma
Pfaff M, Costa P, Tang H, Sailo B, Sharma A, Ahuja N. Decoding the Epigenome: Comparative Analysis of Uterine Leiomyosarcoma and Leiomyoma. Cancers 2025, 17: 2610. PMID: 40867239, PMCID: PMC12384543, DOI: 10.3390/cancers17162610.Peer-Reviewed Original ResearchUterine leiomyosarcomaUterine leiomyomaSmooth muscle tumorsClass I expressionTherapeutic targetDysregulation of signaling pathwaysHistone deacetylasesGlobal DNA hypomethylationMuscle tumorsExtracellular matrix accumulationPotential therapeutic targetTumor typesTumor pathogenesisHistone acetyltransferase activityI expressionClinical managementTumorWnt/b-cateninDNA hypomethylationPathway dysregulationMatrix accumulationDiagnostic biomarkersEpigenetic profilesMethylation patternsEpigenetic landscape
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