2022
Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study
Kauke-Navarro M, Panayi AC, Formica R, Marty F, Parikh N, Foroutanjazi S, Safi AF, Mardini S, Razonable RR, Morelon E, Gelb B, Rodriguez E, Lassus P, Pomahac B. Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study. Transplantation 2022, 106: 2031-2043. PMID: 35389381, DOI: 10.1097/tp.0000000000004132.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyAntiviral prophylaxisCohort studyComposite allotransplantationInternational multicenter retrospective cohort studyMulticenter retrospective cohort studyCMV-related complicationsFirst year posttransplantHigh-risk transplantsMore rejection episodesHigh-risk groupFacial Vascularized Composite AllotransplantationAllograft-related complicationsVascularized Composite AllotransplantationPaucity of dataAllograft lossCMV diseaseCMV viremiaCytomegalovirus serostatusR serostatusRejection episodesCMV infectionPrompt treatmentActive surveillancePatients
2025
Characterizing the epidemiology of traumatic ear injuries: A 20 year analysis of emergency department visits in the U.S
Boroumand S, Katsnelson B, Oh S, Lewis K, Huelsboemer L, Stögner V, Kauke-Navarro M, Haykal S, Pomahac B. Characterizing the epidemiology of traumatic ear injuries: A 20 year analysis of emergency department visits in the U.S. Injury 2025, 56: 112287. PMID: 40168889, DOI: 10.1016/j.injury.2025.112287.Peer-Reviewed Original ResearchEar injuryNon-geriatric adultsNEISS databaseFall risk measuresEmergency department visitsPublic health strategiesEmergency department dispositionGeriatric patientsPrevent such injuriesTwo-proportion z-testPhysical therapyHealth strategiesDepartment visitsFall injuriesPatient educationSports activitiesGeriatric adultsAge groupsAge demographicsBonferroni correctionEar lacerationsFragility of tissuesFrequency of hematomaIncident locationTraumatic injurySobering Overview of Traumatic Craniofacial Injuries Involving Drugs and Alcohol: A Comprehensive Analysis of the NEISS Database
Boroumand S, Ajjawi I, Boroumand T, Allam O, Huelsboemer L, Stögner V, Kauke-Navarro M, Haykal S, Alperovich M, Pomahac B. Sobering Overview of Traumatic Craniofacial Injuries Involving Drugs and Alcohol: A Comprehensive Analysis of the NEISS Database. Craniomaxillofacial Trauma & Reconstruction 2025, 18: 13. DOI: 10.3390/cmtr18010013.Peer-Reviewed Original ResearchCraniofacial injuriesTraumatic craniofacial injuriesEmergency departmentOdds of hospital admissionTwo-proportion z-testFrequent presentationNEISS databaseED presentationsIntoxicated patientsCraniofacial anatomyHospital admissionPatientsEpidemiological findingsTraumatic injuryDemographic variablesInjuryDrugDrugs/alcoholContext of drugZ-testInternal injuriesStairs/stepsHematomaAlcoholOddsThe Use of Acellular Dermal Matrix May Not Increase 30-Day Complications in Direct-to-Implant Breast Reconstruction: A Multi-institutional Analysis of 10,177 Cases.
Knoedler S, Klimitz F, Friedrich S, Schemet L, Broer P, Cherubino M, Könneker S, Kim B, Pomahac B, Kauke-Navarro M. The Use of Acellular Dermal Matrix May Not Increase 30-Day Complications in Direct-to-Implant Breast Reconstruction: A Multi-institutional Analysis of 10,177 Cases. Annals Of Plastic Surgery 2025 PMID: 39874559, DOI: 10.1097/sap.0000000000004234.Peer-Reviewed Original ResearchDirect-to-implant breast reconstructionDirect-to-implantAcellular dermal matrixBreast reconstructionPropensity score matchingHigher risk of short-term complicationsMedical complicationsAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseIncreased 30-day complicationsMultivariate analysisRisk of short-term complicationsQuality Improvement Program databaseThirty-day postoperative complicationsSurgical complication rateIncorporation of acellular dermal matrixScore matchingMulti-institutional analysisMulti-institutional databaseShort-term complicationsComplication ratePostoperative complicationsWound dehiscenceNo significant differenceThe prognostic relevance of donor-specific antibodies in facial transplantation – A retrospective cohort study
Huelsboemer L, Hosseini H, Klimitz F, Diatta F, Boroumand S, O'Brien C, Parikh N, Stögner V, Formica R, Ko C, Azzi J, Draper E, Lian C, Murphy G, Pomahac B, Kauke-Navarro M. The prognostic relevance of donor-specific antibodies in facial transplantation – A retrospective cohort study. Journal Of Plastic Reconstructive & Aesthetic Surgery 2025, 103: 286-296. PMID: 40043533, DOI: 10.1016/j.bjps.2025.01.028.Peer-Reviewed Original ResearchDe novo donor-specific antibodiesDonor-specific antibodiesDonor-specific antibody positivityChronic rejectionC4d depositionGraft lossPrognostic relevanceRejection gradeGrades of acute cellular rejectionDonor-specific antibody statusOccurrence of chronic rejectionTime pointsFacial vascularized composite allotransplantationAcute rejection gradeAcute cellular rejectionTissue typing laboratoriesAcute rejection eventsRetrospective cohort studyTransplant-related outcomesFace transplant patientsVascularized composite allotransplantationCellular rejectionTransplant patientsC4d levelsRetrospective analysisB-cell infiltration distinguishes mucosal from skin patterns of rejection in facial vascularized composite allografts
Kauke-Navarro M, Crisler W, Younis N, Khetani R, Sadigh S, Teague J, Ho Sui S, Ko C, Zhan Q, Steuart S, Treister N, Pober J, Azzi J, Clark R, Pomahac B. B-cell infiltration distinguishes mucosal from skin patterns of rejection in facial vascularized composite allografts. American Journal Of Transplantation 2025 PMID: 39842779, DOI: 10.1016/j.ajt.2025.01.013.Peer-Reviewed Original ResearchFacial vascularized composite allotransplantationPeripheral blood mononuclear cellsB cell infiltrationB cellsMucosal rejectionRejection monitoringFacial vascularized composite allograftT cell-mediated rejectionSigns of immune activationNon-rejection biopsiesGranzyme B expressionB cell populationsInnate-like B cellsBlood mononuclear cellsVascularized composite allograftsVascularized composite allotransplantationAcute rejectionOral mucosaT cellsPattern of rejectionImmune activationMucosal biopsiesPlasma cellsSkin biopsiesMononuclear cells
2024
Unveiling Inequities: Racial Disparities in Risk-Reducing Mastectomy for Breast Cancer Prevention
Knoedler S, Diatta F, Klimitz F, Noel O, Kempa J, Obed D, Song S, Mayer H, Kim B, Kauke-Navarro M, Pomahac B, Butler P. Unveiling Inequities: Racial Disparities in Risk-Reducing Mastectomy for Breast Cancer Prevention. Clinical Breast Cancer 2024, 25: e312-e320. PMID: 39743397, DOI: 10.1016/j.clbc.2024.12.004.Peer-Reviewed Original ResearchRisk-reducing mastectomyMinority patientsRacial minority patientsBreast cancer preventionRacial disparitiesQuality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramWhite patientsCancer preventionStudy investigates racial disparitiesBreast cancer riskEquitable healthcare accessBlack patientsRates of obesityPrevalence of obesityBlack/African American womenImprovement programsPostoperative outcomesOutpatient surgeryAmerican College of Surgeons National Surgical Quality Improvement ProgramSurgeons National Surgical Quality Improvement ProgramHealth equityBreast cancer treatmentHealthcare accessLong-term posttransplant-related bone volumetric changes in eight face transplant recipients – A single-center retrospective case series
Huelsboemer L, Boroumand S, Boroumand T, Vafa A, Parikh N, Chiarella L, Knoedler L, Stögner V, Hung P, Sadigh S, Haykal S, Pomahac B, Kauke-Navarro M. Long-term posttransplant-related bone volumetric changes in eight face transplant recipients – A single-center retrospective case series. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 101: 220-230. PMID: 39848075, DOI: 10.1016/j.bjps.2024.11.025.Peer-Reviewed Original ResearchFacial vascularized composite allograftBone volume changesBone volumeChronic rejection processRetrospective case seriesComputed tomography scanBone volume lossWilcoxon rank sum testNative boneSignificant median decreaseBone volume stabilityRank sum testFace transplant recipientsBone remodeling ratesVascularized composite allograftsChronic immunosuppressionTooth lossTransplant recipientsAllograft cohortCase seriesTomography scanVolume lossMedian decreaseMedical comorbiditiesHistopathological analysisProtein as a preoperative predictor – Impact of hypoalbuminemia on 30-day outcomes of breast reduction surgery
Knoedler S, Klimitz F, Diatta F, Perozzo F, Sofo G, Alfertshofer M, Cherubino M, Mayer H, Panayi A, Kim B, Pomahac B, Kauke-Navarro M. Protein as a preoperative predictor – Impact of hypoalbuminemia on 30-day outcomes of breast reduction surgery. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 100: 144-152. PMID: 39615141, DOI: 10.1016/j.bjps.2024.11.011.Peer-Reviewed Original ResearchBreast reduction surgeryImpact of hypoalbuminemiaReduction surgeryBody mass indexPostoperative complicationsSurgical outcomesMass indexAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseAssociated with adverse surgical outcomesPredictor of postoperative complicationsIncreased risk of complicationsQuality Improvement Program databasePreoperative nutritional assessmentSuperficial incisional infectionNormal albumin levelsBiomarkers of malnutritionHigher body mass indexAdverse surgical outcomesRisk of complicationsImprove surgical outcomesChronic obstructive pulmonary diseaseMultivariate logistic regressionObstructive pulmonary diseasePerioperative safety of risk-reducing mastectomy
Knoedler S, Diatta F, Kasparbauer F, Knoedler L, Kim B, Pomahac B, Kauke-Navarro M. Perioperative safety of risk-reducing mastectomy. British Journal Of Cancer 2024, 131: 1721-1723. PMID: 39501091, PMCID: PMC11589771, DOI: 10.1038/s41416-024-02897-z.Peer-Reviewed Original ResearchTen-year follow-up after face transplantation—A single-center retrospective cohort study
Huelsboemer L, Kauke-Navarro M, Boroumand S, Parikh N, Hosseini H, Yu C, Stögner V, Ko C, Perry B, Formica R, Hung P, Mahajan A, Azzi J, Murphy G, Pomahac B. Ten-year follow-up after face transplantation—A single-center retrospective cohort study. American Journal Of Transplantation 2024, 25: 611-622. PMID: 39413877, DOI: 10.1016/j.ajt.2024.10.007.Peer-Reviewed Original ResearchChronic rejectionFace transplantationFollow-upSingle center retrospective cohort studyFunctional outcomesSensory returnAnalysis of functional outcomesMedian follow-upIncidence of malignancyMetabolic side effectsGraft rejection episodesComputed tomography angiogramRetrospective cohort studyEvidence of vasculopathyFollow-up periodLong-term outcomesYear follow-upFacial motor functionRejection episodesInfectious complicationsTransplant recipientsPatient ageGraft retentionMedical complicationsCohort studyAnalyzing Question Characteristics Influencing ChatGPT’s Performance in 3000 USMLE®-Style Questions
Alfertshofer M, Knoedler S, Hoch C, Cotofana S, Panayi A, Kauke-Navarro M, Tullius S, Orgill D, Austen W, Pomahac B, Knoedler L. Analyzing Question Characteristics Influencing ChatGPT’s Performance in 3000 USMLE®-Style Questions. Medical Science Educator 2024, 35: 257-267. PMID: 40144074, PMCID: PMC11933601, DOI: 10.1007/s40670-024-02176-9.Peer-Reviewed Original ResearchRisk factors and outcomes after surgery for malignant neoplasm of the parotid gland: An ACS-NSQIP study
Knoedler L, Knoedler S, Hoch C, Safi A, Wollenberg B, Alfertshofer M, Pomahac B, Kauke-Navarro M, Clune J. Risk factors and outcomes after surgery for malignant neoplasm of the parotid gland: An ACS-NSQIP study. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 101: 264-274. PMID: 39448324, DOI: 10.1016/j.bjps.2024.09.067.Peer-Reviewed Original ResearchBlood urea nitrogenRisk factorsRenal failureParotid glandMalignant neoplasmsAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseAssociated with higher creatinineNational Surgical Quality Improvement Program databaseMicrosurgical proceduresPre-operative risk factorsQuality Improvement Program databaseRisk of postoperative adverse eventsBlood urea nitrogen levelsHigher ASA classPostoperative adverse eventsOccurrence of complicationsPost-surgical outcomesTumor resectionComplication rateFlap surgeryPostoperative outcomesACS-NSQIPASA classHigher creatinineEvaluating two decades of traumatic amputations treated in US emergency departments: A multicenter epidemiological analysis from NEISS
Boroumand S, Ajjawi I, Park N, Huelsboemer L, Stögner V, Bach K, Kauke-Navarro M, Haykal S, Pomahac B, Colen D. Evaluating two decades of traumatic amputations treated in US emergency departments: A multicenter epidemiological analysis from NEISS. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 99: 63-66. PMID: 39353285, DOI: 10.1016/j.bjps.2024.09.068.Peer-Reviewed Original ResearchReading Between the Tabloids: An Objective Analysis of the Quality and Readability of Patient Encountered Online Material for Face Transplantation
Boroumand S, Littleton A, Aregbe A, Gu E, Huelsboemer L, Stögner V, Lewis K, Kauke-Navarro M, Haykal S, Pomahac B. Reading Between the Tabloids: An Objective Analysis of the Quality and Readability of Patient Encountered Online Material for Face Transplantation. Journal Of Craniofacial Surgery 2024, 36: 89-94. PMID: 39471279, DOI: 10.1097/scs.0000000000010668.Peer-Reviewed Original ResearchNews sourcesOnline materialsNewsFace transplant programsThird-party sourcesReadability metricsFace transplantationReadabilityTransplant programsPost hoc Tukey multiple comparison testTukey's multiple comparison testMultiple comparison testReputable sourcesTabloidsReadability of online materialsAuthorshipOne-way ANOVATransplantationThird-party sitesJAMA benchmark criteriaDiscernmentEncountersJAMA benchmarksThe impact of age on outcomes after breast reduction surgery – A multi-institutional data analysis of 40,958 cases
Knoedler S, Perozzo F, Jiang J, Kosyk M, Alfertshofer M, Schenck T, Kern B, Sofo G, Knoedler L, Panayi A, Pomahac B, Kauke-Navarro M, Kim B. The impact of age on outcomes after breast reduction surgery – A multi-institutional data analysis of 40,958 cases. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 98: 318-330. PMID: 39321535, DOI: 10.1016/j.bjps.2024.09.027.Peer-Reviewed Original ResearchReduction mammoplastyFemale patientsMedical complicationsImpact of ageAmerican College of Surgeons National Surgical Quality Improvement ProgramSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramPatients aged <Patients aged >Breast reduction surgeryAdult female patientsQuality Improvement ProgramPostoperative morbiditySurgical complicationsPostoperative outcomesPatient ageReduction surgeryDeterminants of riskMultivariate analysisAmerican CollegeComplicationsLow riskPatientsMammoplastyThe role of C4d and donor specific antibodies in face and hand transplantation—a systematic review
Huelsboemer L, Moscarelli J, Dony A, Boroumand S, Kochen A, Knoedler L, Yu C, Hauc S, Stögner V, Formica R, Lian C, Murphy G, Pomahac B, Kauke-Navarro M. The role of C4d and donor specific antibodies in face and hand transplantation—a systematic review. Frontiers In Transplantation 2024, 3: 1442006. PMID: 39291278, PMCID: PMC11405992, DOI: 10.3389/frtra.2024.1442006.Peer-Reviewed Original ResearchDonor-specific antibodiesSerum donor-specific antibodiesAntibody-mediated rejectionHigher rejection gradesVascularized composite allotransplantationC4d depositionRejection gradeCellular rejectionRejection episodesSpecific antibodiesDonor-specific antibody statusManagement of antibody-mediated rejectionFace transplantationAcute cellular rejectionAcute rejection episodesAssociated with high gradeTime of biopsyAntibody mediated rejectionFisher's exact testMann-Whitney U testSystematic review of electronic databasesMechanisms of rejectionSystematic reviewReview of electronic databasesC4d stainingTo Face Transplant or Not Face Transplant? Evaluating the Limitations of ChatGPT's Consideration of Ethical Themes
Boroumand S, Gu E, Huelsboemer L, Stögner V, Parikh N, Kauke-Navarro M, Pomahac B. To Face Transplant or Not Face Transplant? Evaluating the Limitations of ChatGPT's Consideration of Ethical Themes. Annals Of Plastic Surgery 2024, 93: 527-529. PMID: 39331750, DOI: 10.1097/sap.0000000000004072.Peer-Reviewed Original ResearchLetter in Reply to Comment on: Gynecomastia Surgery in 4996 Male Patients Over 14 Years: A Retrospective Analysis of Surgical Trends, Predictive Risk Factors, and Short-Term Outcomes
Kauke-Navarro M, Klimitz F, Pomahac B. Letter in Reply to Comment on: Gynecomastia Surgery in 4996 Male Patients Over 14 Years: A Retrospective Analysis of Surgical Trends, Predictive Risk Factors, and Short-Term Outcomes. Aesthetic Plastic Surgery 2024, 48: 4653-4655. PMID: 39085527, DOI: 10.1007/s00266-024-04285-7.Peer-Reviewed Original ResearchC-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via subset-selective monocyte activation
Kiefer J, Zeller J, Schneider L, Thomé J, McFadyen J, Hoerbrand I, Lang F, Deiss E, Bogner B, Schaefer A, Chevalier N, Horner V, Kreuzaler S, Kneser U, Kauke-Navarro M, Braig D, Woollard K, Pomahac B, Peter K, Eisenhardt S. C-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via subset-selective monocyte activation. Journal Of Advanced Research 2024 PMID: 38992424, DOI: 10.1016/j.jare.2024.07.007.Peer-Reviewed Original ResearchAcute allograft rejectionC-reactive proteinVascularized composite allotransplantationAllograft rejectionAcute rejectionAllograft survivalGraft rejectionAttenuate acute allograft rejectionPreventing acute allograft rejectionImmune responseLong-term allograft survivalFacial vascularized composite allotransplantationClinical allograft rejectionReduced allograft survivalChronic allograft rejectionIntravital imagingNon-classical monocytesMarkers of inflammationAcute-phase reactantsImmune-inflammatory reactionPro-inflammatory propertiesMononuclear phagocyte systemAcute-phase responseGraft infiltrationInnate immune response
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