Adjunct Faculty
Adjunct Faculty are scientists or others who are employed outside of the school but have a specific, mutually beneficial role to Yale School of Medicine department programs.
Adjunct rank detailsCarla Rothlin, PhD
Professor AdjunctDownloadHi-Res Photo
About
Copy Link
Titles
Professor Adjunct
Co-Leader, Cancer Immunology, Yale Cancer Center
Appointments
Immunobiology
Professor AdjunctPrimary
Other Departments & Organizations
- Cancer Immunology
- Immunobiology
- Immunology
- Interdepartmental Neuroscience Program
- K12 Calabresi Immuno-Oncology Training Program (IOTP)
- Liver Center
- Microbiology
- Neuroscience Track
- Program for Neuroinflammation
- Rheumatic Diseases Research Core
- Rothlin Ghosh Lab
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Fibrosis Program
- Yale Stem Cell Center
- Yale Ventures
Education & Training
- PhD
- University of Buenos Aires (2002)
Research
Copy Link
Overview
Immunobiology; Immune Homeostasis; TAM Receptor Tyrosine Kinases
Medical Research Interests
Inflammation
ORCID
0000-0002-5693-5572
Research at a Glance
Yale Co-Authors
Frequent collaborators of Carla Rothlin's published research.
Publications Timeline
A big-picture view of Carla Rothlin's research output by year.
Research Interests
Research topics Carla Rothlin is interested in exploring.
Sourav Ghosh, PhD
Joseph Craft, MD
Antariksh Tyagi, PhD
Aurobind Vidyarthi, PhD
Eyiyemisi Damisah, MD
Jaime Grutzendler, MD
27Publications
2,511Citations
Inflammation
Publications
2025
You know my NAMs
Ghosh S, Rothlin C. You know my NAMs. Immunity 2025, 58: 1179-1181. PMID: 40367920, DOI: 10.1016/j.immuni.2025.04.025.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsCholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Belabed M, Park M, Blouin C, Balan S, Moon C, Freed G, Quijada-Álamo M, Peros A, Mattiuz R, Reid A, Yatim N, Boumelha J, Azimi C, LaMarche N, Troncoso L, Amabile A, Le Berichel J, Chen S, Wilk C, Brown B, Radford K, Ghosh S, Rothlin C, Yvan-Charvet L, Marron T, Puleston D, Wagenblast E, Bhardwaj N, Lamaze C, Merad M. Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer. Nature Immunology 2025, 26: 188-199. PMID: 39838105, DOI: 10.1038/s41590-024-02065-8.Peer-Reviewed Original ResearchCitationsAltmetricConceptsConventional dendritic cellsNiemann-Pick disease type C1Maturation of conventional dendritic cellsExpression of maturation markersCholesterol mobilizationAnti-tumor immunityReceptor tyrosine kinase AXLDendritic cell maturationResponse to cancerTyrosine kinase AXLDendritic cellsImmune receptor signalingMaturation markersAuto-immunityCell maturationReceptor signalingImmunogenic responseTherapeutic targetCholesterol transportLipid nanodomainsSubcellular mechanismsCholesterolType C1CancerCell surface
2024
New potential ligand-receptor axis involved in tissue repair as therapeutic targets in progressive multiple sclerosis
Carrera Silva E, Correale J, Rothlin C, Ortiz Wilczyñski J. New potential ligand-receptor axis involved in tissue repair as therapeutic targets in progressive multiple sclerosis. Journal Of Pharmacology And Experimental Therapeutics 2024, 392: 100029. PMID: 39892997, DOI: 10.1124/jpet.124.002254.Peer-Reviewed Original ResearchCitationsConceptsProgressive multiple sclerosisLigand-receptor axisNeuroprotective therapeutic strategiesMultiple sclerosisTissue repairTherapeutic strategiesRefractory to current treatmentsIncreasing preclinical evidenceStages of multiple sclerosisEarly stages of multiple sclerosisAnti-inflammatoryPromote tissue repairTissue repair processPreclinical evidenceTherapeutic optionsReceptor axisReceptor/ligand pairsCurrent treatmentPathogenic mechanismsMS diseaseBenefit patientsTherapeutic interventionsTherapeutic targetSignaling AxisEra of omics868 AXL restricts cholesterol mobilization, modulating dendritic cell maturation and the immune response to cancer
Belabed M, Park M, Blouin C, Balan S, Moon C, Boumelha J, Peros A, Mattiuz R, Reid A, Azimi C, LaMarche N, Troncoso L, Berichel J, Wilk M, Brown B, Radford K, Ghosh S, Rothlin C, Yvan-Charvet L, Marron T, Puleston D, Bhardwaj N, Lamaze C, Merad M. 868 AXL restricts cholesterol mobilization, modulating dendritic cell maturation and the immune response to cancer. 2024, a982-a982. DOI: 10.1136/jitc-2024-sitc2024.0868.Peer-Reviewed Original ResearchFeeding the wrath with myelin
Ghosh S, Rothlin C. Feeding the wrath with myelin. Trends In Immunology 2024, 45: 729-731. PMID: 39341708, PMCID: PMC11471388, DOI: 10.1016/j.it.2024.09.004.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsStem cells tightly regulate dead cell clearance to maintain tissue fitness
Stewart K, Abdusselamoglu M, Tierney M, Gola A, Hur Y, Gonzales K, Yuan S, Bonny A, Yang Y, Infarinato N, Cowley C, Levorse J, Pasolli H, Ghosh S, Rothlin C, Fuchs E. Stem cells tightly regulate dead cell clearance to maintain tissue fitness. Nature 2024, 633: 407-416. PMID: 39169186, PMCID: PMC11390485, DOI: 10.1038/s41586-024-07855-6.Peer-Reviewed Original ResearchCitationsAltmetricConceptsStem cellsImmune-privileged nicheHair follicle stem cellsStem cell functionFollicle stem cellsTissue fitnessMesenchymal tissue cellsBillions of cellsDendritic cellsTissue stemProgenitor cellsPreserving tissue integrityDead cell clearanceClearance genesCell clearanceCell functionFunctional evidenceDying CellsHealthy counterpartsCell deathNon-motileTissue cellsHair cycleProfessional phagocytesApoptotic corpsesThe amalgam of naive CD4+ T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response
Even Z, Meli A, Tyagi A, Vidyarthi A, Briggs N, de Kouchkovsky D, Kong Y, Wang Y, Waizman D, Rice T, De Kumar B, Wang X, Palm N, Craft J, Basu M, Ghosh S, Rothlin C. The amalgam of naive CD4+ T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response. Immunity 2024, 57: 1893-1907.e6. PMID: 39096910, PMCID: PMC11421571, DOI: 10.1016/j.immuni.2024.07.006.Peer-Reviewed Original ResearchCitationsAltmetricConceptsT cell receptorImmune responseNaive CD4+ T cellsCD4+ T cellsIFN-IHelminth infectionsNippostrongylus brasiliensis infectionDecreased immune responseType I interferonNaive TT cellsMemory-likeUnrelated antigensTranscriptional changesExtracellular matrixSPF miceCell receptorsI interferonGerm-freeResponse to certain environmental cuesInfectionMiceFunctional changesCell transcriptional statesTranscriptional heterogeneityHow and why eLife selects papers for peer review
Behrens T, Dalal Y, Harper D, Weigel D, Ajijola O, Andreotti A, Araújo S, Banerjee U, Bhargava B, Bi Y, Büchel C, Campelo F, Cardona A, Cheah K, Chen L, Choi M, Colgin L, Cooper J, Cui Q, de Lange F, Desplan C, Dötsch V, El-Deiry W, Franco E, Frank M, Garrett W, Gold J, Hauf S, Huang C, Huguenard J, James D, Kana B, Kapahi P, King A, Kleine-Vehn J, Kornmann B, Liu C, Luo H, Maduke M, Makin T, Marquand A, Marston A, Mistry P, Moses A, Nelson S, Ng T, Ojala P, Perry G, Poirazi P, Postovit L, Ramachandran S, Rasmann S, Rath S, Roiser J, Ron D, Rothlin C, Schoggins J, Schuman M, Shinn-Cunningham B, Shoback D, Smith L, Soldati-Favre D, Stainier D, Sussel L, Swartz K, Taffe M, Taniguchi T, VijayRaghavan K, Walczak A, Wassum K, White R, Wong M, Yan W, Yuen T, Chugh M, Han L, Marei S, Mencia R, Mittal D, Ochola E, Romani F, Yap L. How and why eLife selects papers for peer review. ELife 2024, 13: e100571. PMID: 39041434, PMCID: PMC11265793, DOI: 10.7554/elife.100571.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsIn the Eyes of the Beholder—New Mertk Knockout Mouse and Re-Evaluation of Phagocytosis versus Anti-Inflammatory Functions of MERTK
Ghosh S, Finnemann S, Vollrath D, Rothlin C. In the Eyes of the Beholder—New Mertk Knockout Mouse and Re-Evaluation of Phagocytosis versus Anti-Inflammatory Functions of MERTK. International Journal Of Molecular Sciences 2024, 25: 5299. PMID: 38791338, PMCID: PMC11121519, DOI: 10.3390/ijms25105299.Peer-Reviewed Original ResearchCitationsConceptsReceptor tyrosine kinasesFamily of receptor tyrosine kinasesTAM family of receptor tyrosine kinasesEarly-onset photoreceptor degenerationKnockout mouse modelMolecular functionsNegative regulator of inflammationKnockout phenotypesNegative regulatorMouse geneticsRegulation of inflammationMolecular approachesEmbryonic stem cellsAnti-inflammatory functionsRetinal degenerationTyrosine kinasePhotoreceptor degenerationKnockout miceKnockout modelsMouse modelRodent modelsTAM familyMerTK functionStem cellsAllelesApoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages
Liebold I, Al Jawazneh A, Casar C, Lanzloth C, Leyk S, Hamley M, Wong M, Kylies D, Gräfe S, Edenhofer I, Aranda-Pardos I, Kriwet M, Haas H, Krause J, Hadjilaou A, Schromm A, Richardt U, Eggert P, Tappe D, Weidemann S, Ghosh S, Krebs C, A-Gonzalez N, Worthmann A, Lohse A, Huber S, Rothlin C, Puelles V, Jacobs T, Gagliani N, Bosurgi L. Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages. Science 2024, 384: eabo7027. PMID: 38574142, DOI: 10.1126/science.abo7027.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsApoptotic neutrophilsApoptotic cellsIL-4-induced gene expressionUptake of apoptotic neutrophilsApoptotic cell clearanceCell lineage identityResponse to IL-4Cell identityEfferocytic macrophagesPhagocytic receptorsGene expressionLineage identityCell clearanceApoptotic hepatocytesHeterogeneous cellsCellsMouse modelT cellsParasite-induced pathologyIL-4HepatocytesMacrophagesInterleukin-4EngulfmentPhenotype
Academic Achievements & Community Involvement
Copy Link
Honors
honor HHMI Faculty Scholar
10/01/2016National AwardHoward Hughes Medical InstituteDetailsUnited Stateshonor Early Excellence Award
07/01/2011UnknownAmerican Asthma FoundationDetailsUnited Stateshonor Novel Research Grant
02/01/2011UnknownLupus Research InstituteDetailsUnited Stateshonor Senior Research Award
01/01/2010UnknownCrohn's and Colitis Foundation of AmericaDetailsUnited Stateshonor Special Fellow (declined in favor of AHA award)
05/02/2008UnknownLeukemia and Lymphoma SocietyDetailsUnited States
News
Copy Link
News
Get In Touch
Copy Link