Declan McGuone, FRCPath Neuro, MBBCh
Associate Professor of PathologyCards
About
Research
Publications
2025
Pathological Calcium Signaling in Traumatic Brain Injury and Alzheimer’s Disease: From Acute Neuronal Injury to Chronic Neurodegeneration
Neuschmid S, Schallerer C, Ehrlich B, McGuone D. Pathological Calcium Signaling in Traumatic Brain Injury and Alzheimer’s Disease: From Acute Neuronal Injury to Chronic Neurodegeneration. International Journal Of Molecular Sciences 2025, 26: 9245. PMID: 41009808, PMCID: PMC12471116, DOI: 10.3390/ijms26189245.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseCalcium-dependent protease calpainPharmacological inhibitionCalcium signalingTau hyperphosphorylationAmyloid-bLoss of calcium homeostasisProtein misfoldingCalcium-dependent enzymesSignaling proteinsAD riskProtease calpainAD modelProtease networkDisrupted calcium signalingTraumatic brain injuryUpstream driversEnzyme activityPathological calcium signalingSynaptic architectureCalcium dysregulationAxonal transportNeuronal deathEssential scaffoldsCalcium homeostasisCalpain in Traumatic Brain Injury: From Cinderella to Central Player
Schallerer C, Neuschmid S, Ehrlich B, McGuone D. Calpain in Traumatic Brain Injury: From Cinderella to Central Player. Cells 2025, 14: 1253. PMID: 40862734, PMCID: PMC12384584, DOI: 10.3390/cells14161253.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryTherapeutic targetCalcium-dependent protease calpainBrain injuryCause of deathSecondary injury cascadesPreclinical efficacyTraumatic brain injury pathologyGlobal health concernClinical dataRegulatory proteinsCalcium homeostasisInjury cascadeCalcium dysregulationProtein fragmentsProtease calpainCalpain substratesCalpain activityMitochondrial dysfunctionProtease activityAxonal integrityNeuronal compartmentsSelective inhibitorsCentral playerSynaptic functionReclassification of pineal tumor as high-grade astrocytoma with piloid features through methylation profiling: illustrative case
Dincer A, Kim M, Hüseyinoglu Z, Chavez M, McGuone D, Moliterno J. Reclassification of pineal tumor as high-grade astrocytoma with piloid features through methylation profiling: illustrative case. Journal Of Neurosurgery Case Lessons 2025, 9: case24778. PMID: 40324324, PMCID: PMC12051993, DOI: 10.3171/case24778.Peer-Reviewed Original ResearchHigh-grade astrocytomasPiloid featuresHigh-grade neuroepithelial tumorCNS tumor classificationGross-total resectionHigh-grade pathologyEndoscopic third ventriculostomyRight-sided weaknessMethylation profilesClinically relevant changesNeuroepithelial tumorsSuboccipital craniectomyTumor sizePineal tumorsPineal regionThird ventriculostomyTumor typesClinical trialsGlioma subtypesBiopsy samplesDNA methylation profilesTumorTargeted therapeuticsHistological appearanceInterval increaseTDP-43 Microvasculopathy Associated Astrogliosis and Blood-Brain Barrier Breach in the Context of Alzheimer’s Disease and COVID-19
Mathew S, McGuone D, Patel K, Gopal P. TDP-43 Microvasculopathy Associated Astrogliosis and Blood-Brain Barrier Breach in the Context of Alzheimer’s Disease and COVID-19. Physiology 2025, 40: 0537. DOI: 10.1152/physiol.2025.40.s1.0537.Peer-Reviewed Original ResearchAD brainAlzheimer's diseaseBlood-brain barrier breachPTDP-43 inclusionsTDP-43Human AD brainsDorsolateral prefrontal cortexContext of Alzheimer's diseaseDevelopment of ADAge-related neurodegenerative diseasesPTDP-43Phosphorylated TDP-43Tight junction proteinsComorbid COVID-19SARS-CoV-2Prefrontal cortexInvasion of SARS-CoV-2Cognitive changesLoss of barrier integrityViral RNANeuropsychiatric problemsZonula occludens-1Increased transendothelial migrationMarker proteinsBlood-brain barrierNeuropathology Intraoperative Consultation
Leelatian N, McGuone D. Neuropathology Intraoperative Consultation. Seminars In Diagnostic Pathology 2025, 42: 150899. PMID: 40203540, DOI: 10.1016/j.semdp.2025.150899.Peer-Reviewed Original ResearchConceptsIntra-operative consultationImaging findingsOptimizing specimen handlingAdequate tissue samplingSurgical approachDiagnostic pitfallsPre-operativelyDifferential diagnosisSurgical pathologistsAncillary studiesNeurosurgery teamDiagnostic specimensClinical vignettesDiagnostic algorithmSurgical guidanceNeuropathological specimensTissue samplesSpecimen handlingNeuropathologyAbusive Head Trauma in Infants and Children: Technical Report.
Narang S, Haney S, Duhaime A, Martin J, Binenbaum G, de Alba Campomanes A, Barth R, Bertocci G, Care M, McGuone D, Laskey A, Asnes A, Brown V, Girardet R, Heavilin N, Kissoon N, McGregory K, Morgan P, Rosado N, Flaherty E, Sirotnak A, Haney S, Gavril A, Hoffert Gilmartin A, Idzerda S, Messner S, Legano L, Mohr B, Moles R, Palusci V, Nienow S, Budzak A, Suh D, Yoo S, Dumitrescu A, Fredrick D, Gise R, Strominger M, Rubin S, Karr D, Nischal K, Roarty J, Otero H, Milla S, Mercado-Deane M, Alazraki A, Annam A, Benya E, Acharya P, Brown B, Barton K, Daugherty R, Albert G, Bauer D, Ducis K, Lam S, Martin J, Rocque B, Aldana P, Brockmeyer D, Duhaime A, Jea A, Otero H, Milla S, Mercado-Deane M, Alazraki A, Annam A, Benya E, Acharya P, Brown B, Barton K, Daugherty R, Albert G, Bauer D, Ducis K, Lam S, Martin J, Rocque B, Aldana P, Brockmeyer D, Duhaime A, Jea A. Abusive Head Trauma in Infants and Children: Technical Report. 2025, 155 PMID: 39992695, DOI: 10.1542/peds.2024-070457.Peer-Reviewed Original ResearchExploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury
Wachtler N, O’Brien R, Ehrlich B, McGuone D. Exploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury. Pharmaceuticals 2025, 18: 223. PMID: 40006037, PMCID: PMC11859800, DOI: 10.3390/ph18020223.Peer-Reviewed Original ResearchCalcium signalingCalcium channelsTherapeutic strategiesCalcium homeostasisFunction of calcium channelsDysregulated calcium signalingModulation of injuryTraumatic brain injuryBrain injuryLoss of calcium homeostasisBlast-related traumatic brain injuryDevelopment of neuroprotective interventionsIntracellular calcium dynamicsPlasma membrane stabilityExtracellular calciumBlast traumatic brain injuryPreclinical modelsTherapeutic outcomesNeuroprotective interventionsMembrane abnormalitiesPharmacological inhibitorsNeuronal somataExclusion criteriaCalcium dynamicsSecondary injurySomatic SMARCB1 mutation in spinal meningioma represents branched evolution in a patient with multiple sporadic meningiomas
Gupta M, Samiappan S, Alanya H, Yalcin K, Gultekin B, Sharaf R, Elsamadicy A, Figuera D, Samuel N, Mishra-Gorur K, Kolb L, McGuone D, Gunel M, Erson-Omay E, Moliterno J, Mendel E. Somatic SMARCB1 mutation in spinal meningioma represents branched evolution in a patient with multiple sporadic meningiomas. Neuro-Oncology Advances 2025, 7: vdaf067. PMID: 40386121, PMCID: PMC12081948, DOI: 10.1093/noajnl/vdaf067.Peer-Reviewed Original Research
2024
EPCO-35. GENOMIC CHARACTERIZATION OF GROWTH HORMONE SECRETING PITUITARY ADENOMAS
Alanya H, Yalcin K, Hilton B, Gultekin B, Mishra-Gorur K, McGuone D, Gunel M, Omay S, Erson-Omay Z. EPCO-35. GENOMIC CHARACTERIZATION OF GROWTH HORMONE SECRETING PITUITARY ADENOMAS. Neuro-Oncology 2024, 26: viii9-viii9. PMCID: PMC11553213, DOI: 10.1093/neuonc/noae165.0034.Peer-Reviewed Original ResearchGH-secreting pituitary adenomasWhole-exome sequencingPituitary adenomasGNAS mutationsCopy number variationsSporadic GH-secreting pituitary adenomasGrowth hormone (GH)-secreting pituitary adenomasGenomic profilingGrowth hormone secreting pituitary adenomaSecreting pituitary adenomasBlood samplesComprehensive genomic characterizationSomatic GNAS mutationsSingle nucleotide variantsMatched blood samplesGenomic instabilityAssessment of genomic instabilityStatistically significant differenceTumor sizeClinical featuresTumor samplesClinical dataTumorExome sequencingBrain tumorsRocky Mountain Spotted Fever Encephalitis and “Starry Sky” Pattern on MRI
Mikhaiel J, Parasram M, Park J, Cappucci S, McGuone D, Falcone G, Sheth K, Gilmore E. Rocky Mountain Spotted Fever Encephalitis and “Starry Sky” Pattern on MRI. The Neurologist 2024, 30: 34-38. PMID: 39382206, DOI: 10.1097/nrl.0000000000000586.Peer-Reviewed Original ResearchMagnetic resonance imagingPetechial rashCase reportDiffusion restrictionMagnetic resonance imaging brainMagnetic resonance imaging brain findingsRepeat MRI brainRocky Mountain Spotted FeverUrinary tract infectionFoci of diffusion restrictionRight centrum semiovaleProgression to comaPerivascular lymphocytic infiltrateDiffuse petechial rashTract infectionsClinical presentationViral cultureClinical improvementMRI brainLymphocytic infiltrationLumbar punctureSkin biopsiesElevated proteinNeurological manifestationsPunctate foci
Clinical Care
Overview
Declan McGuone, MBBCh (a medical degree awarded outside the U.S.), is a neuropathologist who focuses on diagnosing diseases of the brain and nervous system. He also provides autopsy pathology to help determine causes of death and anatomic pathology to examine how disease affects tissues.
As an associate professor of pathology at Yale School of Medicine, Dr. McGuone investigates how certain tumors and injuries develop in the nervous system, with the aim of improving patient care.
He received his medical training from the Royal College of Surgeons in Ireland, completed a residency in anatomic pathology at Massachusetts General Hospital, and pursued fellowships in forensic pathology at the New York City Office of the Chief Medical Examiner and neuropathology at Massachusetts General Hospital.
Clinical Specialties
Anatomic Pathology; Autopsy Pathology; Neuropathology
News
News
- September 25, 2023
Pathology Office of Research Affairs Makes an Impact
- May 28, 2021
Recent Research Sheds Light on Link Between Meningiomas and Seizures
Get In Touch
Contacts
Mailing Address
Yale School of Medicine
310 Cedar Street BML254-C
New Haven, CT 06510
United States