Genetic and oncogenic features of RASGRF fusions
Das S, Lenchner D, Jaeger E, Hunihan L, DeSantis D, Fragkogianni S, Ronski K, Wilson F. Genetic and oncogenic features of RASGRF fusions. Npj Precision Oncology 2025, 9: 224. PMID: 40615519, PMCID: PMC12227644, DOI: 10.1038/s41698-025-01017-1.Peer-Reviewed Original ResearchGuanine exchange factorDH domainRNA-seq dataNon-small cell lung carcinomaExchange factorGenetic heterogeneityMembrane localizationCellular transformationChimeric proteinDiverse human malignanciesPH1 domainRas activationMAPK pathway inhibitionTransforming activityOncogenic featuresSubsets of cancersRasGRFOncogenic mechanismsFunctional assaysTargeted therapeutic strategiesRasGRF1Human malignanciesStructural diversityOncogenic fusionsPathway inhibition
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