Marc Schneeberger Pane, PhD
Assistant Professor in Cellular and Molecular PhysiologyCards
Appointments
Contact Info
Cellular & Molecular Physiology
333 Cedar Street, B-Wing, E Level
New Haven, Connecticut 06510
United States
About
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Titles
Assistant Professor in Cellular and Molecular Physiology
Biography
Marc Schneeberger Pané received his B.S. in Pharmacy from Barcelona University, Catalonia in 2010. Next, he received his M.S. in Biomedicine from Barcelona University, Catalonia in 2011. He then studied how the powerhouse of the cell (mitochondria) is responsible for controlling whole body energy balance and metabolism in the canonical site for energy balance control (hypothalamus) with Marc Claret, PhD and earned his Ph.D. in Biomedicine at the Barcelona University, Catalonia in 2015. He then became a KAVLI postdoctoral fellow and a Pathway to Independence fellow in Prof. Jeffrey M.Friedman laboratory at The Rockefeller University. There he conducted whole mount activity maps in energy states to decipher the role of two novel subsets of neurons in the Dorsal Raphe Nucleus of the brainstem in energy balance control. He joined the Department of Cellular and Molecular Physiology at Yale University School of Medicine as an Assistant Professor in July 2022.
The Schneeberger Pané laboratory employs state-of-the-art technologies in neuroscience combining unbiased whole mount imaging of circuits, activity and vasculature; molecular profiling single-cell gene expression technologies, neuoromodulation (optogenetics, and chemogenetics) to understand the fundamental principles in the brain governing homeostasis. The overarching goal of the laboratory is to advance in the understanding of how neuronal, immune and vascular networks coordinately control homeostasis, with a focus on energy homeostasis.
Appointments
Cellular & Molecular Physiology
Assistant ProfessorPrimary
Other Departments & Organizations
- Cancer Signaling Networks
- Cellular & Molecular Physiology
- Interdepartmental Neuroscience Program
- Janeway Society
- Molecular Medicine, Pharmacology, and Physiology
- Neural Disorders
- Neuroscience Track
- Wu Tsai Institute
- Yale Cancer Center
- Yale Center for Molecular and Systems Metabolism (YMSM)
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Education & Training
- NIH Pathway to Independence K99 Fellow
- The Rockefeller University (2022)
- Instructor
- Yale University (2022)
- KAVLI Postdoctoral Fellow
- The Rockefeller University (2019)
- JPB Postdoctoral Fellow
- The Rockefeller University (2017)
- PhD
- Barcelona University, Medicine (2015)
- MS
- Barcelona University, Biomedicine (2011)
- BS
- Barcelona University, Pharmacy (2010)
Research
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Overview
Medical Research Interests
ORCID
0000-0001-7369-104X
Research at a Glance
Yale Co-Authors
Publications Timeline
Tamas Horvath, DVM, PhD
Jean-Leon Thomas, PhD
Ania Jastreboff, MD, PhD
Anne Eichmann, PhD
Daniel Coman, PhD
D. S. Fahmeed Hyder, PhD
Publications
2025
Neurovascular plasticity as a modulator of hypothalamic function
Chen B, Furtado J, Schneeberger M. Neurovascular plasticity as a modulator of hypothalamic function. Reviews In Endocrine And Metabolic Disorders 2025, 1-11. PMID: 40542999, DOI: 10.1007/s11154-025-09982-5.Peer-Reviewed Original ResearchAltmetricCysteine depletion triggers adipose tissue thermogenesis and weight loss
Lee A, Orliaguet L, Youm Y, Maeda R, Dlugos T, Lei Y, Coman D, Shchukina I, Andhey P, Smith S, Ravussin E, Stadler K, Chen B, Artyomov M, Hyder F, Horvath T, Schneeberger M, Sugiura Y, Dixit V. Cysteine depletion triggers adipose tissue thermogenesis and weight loss. Nature Metabolism 2025, 7: 1204-1222. PMID: 40461845, PMCID: PMC12198010, DOI: 10.1038/s42255-025-01297-8.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsWeight lossWhite adipose tissueAdipose browningCaloric restrictionAdipose tissueDietary amino acidsCysteine depletionSulphur amino acids cysteineIncreased energy expenditureAdipose tissue thermogenesisIncreased fat utilizationMetabolic inflammationNoradrenaline signalingOrganismal metabolismAdipose thermogenesisObese miceBrowning of adipocytesIncreased heat productionBrownRemoval of cysteineCore body temperatureAmino acidsEnergy expenditureAmino acid cysteineFat utilizationGLP-1R agonists protect against Alzheimer’s disease by rewiring energy regulation
Na D, Schneeberger Pané M. GLP-1R agonists protect against Alzheimer’s disease by rewiring energy regulation. Nature Aging 2025, 5: 960-961. PMID: 40394226, DOI: 10.1038/s43587-025-00881-7.Peer-Reviewed Original ResearchCitationsAltmetricPrader Willi syndrome; advances in genetics
Hingar S, Schneeberger Pané M, Romero M. Prader Willi syndrome; advances in genetics. Advances In Genetics 2025, 113: 29-52. PMID: 40409799, DOI: 10.1016/bs.adgen.2025.03.001.Peer-Reviewed Original ResearchNeuroprotective effect of small extracellular vesicle-mediated targeting of AMPKα2 in cerebral ischemia
Ouro A, Rodríguez-Díaz A, López-González T, Romaus-Sanjurjo D, Estévez-Salguero Á, Iglesias-Rey R, Rodríguez-Arrizabalaga M, Fernández-Sanmartín P, Castro-Mosquera M, Debasa-Mouce M, Custodia A, Aramburu-Núñez M, Muñoz-González M, Aguiar P, González-García I, Schneeberger M, Nogueiras R, Diéguez C, Castillo J, Sobrino T, López M. Neuroprotective effect of small extracellular vesicle-mediated targeting of AMPKα2 in cerebral ischemia. Metabolism 2025, 167: 156160. PMID: 39961478, PMCID: PMC12005051, DOI: 10.1016/j.metabol.2025.156160.Peer-Reviewed Original ResearchCitationsAltmetric
2024
Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior
Xia M, Lu J, Lan J, Teng T, Shiao R, Sun H, Jin Z, Liu X, Wang J, Wu H, Wang C, Yi H, Qi Q, Li J, Schneeberger M, Shen W, Lu B, Chen L, Ilanges A, Zhou X, Yu X. Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior. Immunity 2024, 58: 218-231.e12. PMID: 39644894, DOI: 10.1016/j.immuni.2024.11.008.Peer-Reviewed Original ResearchCitationsAltmetricRewiring of the glymphatic landscape in metabolic disorders
Chen B, Meseguer D, Lenck S, Thomas J, Schneeberger M. Rewiring of the glymphatic landscape in metabolic disorders. Trends In Endocrinology And Metabolism 2024, 36: 710-720. PMID: 39638721, PMCID: PMC12134147, DOI: 10.1016/j.tem.2024.11.005.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMetabolic dysfunctionNeurological disordersBlood-brain barrier leakageCerebral blood flow disruptionBlood flow disruptionGlymphatic systemTreatment strategiesCognitive declineRisk factorsMetabolic disordersNeurovascular uncouplingBarrier leakageGlymphatic clearance systemMetabolic diseasesDisordersObesityDysfunctionGLP-1 programs the neurovascular landscape
Chen B, Yu X, Horvath-Diano C, Ortuño M, Tschöp M, Jastreboff A, Schneeberger M. GLP-1 programs the neurovascular landscape. Cell Metabolism 2024, 36: 2173-2189. PMID: 39357509, DOI: 10.1016/j.cmet.2024.09.003.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGLP-1R agonismGLP-1RMetabolic healthChronic low-grade inflammationLow-grade inflammationGlucagon-like peptide-1 receptorPersistent health issuesCognitive well-beingNutrient-rich foodsPeptide-1 receptorMetabolic syndromeHealth issuesMetabolic defectsBrain healthMetabolic environmentObesityWell-beingWeight lossHealthMetabolic conditionsAgonismNeurological conditionsThe glymphatic system as a nexus between obesity and neurological diseases
Chen B, Lenck S, Thomas J, Schneeberger M. The glymphatic system as a nexus between obesity and neurological diseases. Nature Reviews Endocrinology 2024, 21: 1-2. PMID: 39304738, PMCID: PMC11801375, DOI: 10.1038/s41574-024-01042-3.Peer-Reviewed Original ResearchCitationsAltmetricThe interactions between energy homeostasis and neurovascular plasticity
Chen B, de Launoit E, Meseguer D, Garcia Caceres C, Eichmann A, Renier N, Schneeberger M. The interactions between energy homeostasis and neurovascular plasticity. Nature Reviews Endocrinology 2024, 20: 749-759. PMID: 39054359, DOI: 10.1038/s41574-024-01021-8.Peer-Reviewed Original ResearchCitationsAltmetricConceptsWestern dietLifestyle interventionNeurovascular systemCurrent obesity epidemicEnergy homeostasisStable body weightLocal neuronal networksRegulate energy balanceNeuronal networksFood intakeObesity epidemicSedentary lifestylePharmacological interventionsNeurovascular plasticityOverall healthNutritional milieuWeight lossLong-term needsCardiovascular systemBody weightEnergy expenditureAdverse effectsBrain centresLifestyleBrain vasculature
Academic Achievements & Community Involvement
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Activities
activity Swiss National Foundation
2022 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity Israel Science Foundation
2022 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity Spanish National Evaluation and Foresight Agency
2019 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity ANR:AAP French National Agency
2020 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity Argentinian Ministry of Science and Technology
2020 - PresentPeer Review Groups and Grant Study SectionsReviewer
Honors
honor Heidi Diabetes Award
09/24/2025International AwardHelmholtz ZenteumDetailsGermanyhonor Alzheimer Disease Research Center Scholar
05/01/2024Yale School of Medicine AwardNeurology DepartmentDetailsUnited Stateshonor Diabetes Research Center Scholar
05/01/2024Yale School of Medicine AwardEndocrinology DepartmentDetailsUnited Stateshonor Matilda Ziegler Foundation Scholar
01/01/2024National AwardMatilda E. Ziegler FoundationDetailsUnited Stateshonor Yale SenNet Scholar
01/01/2024Yale School of Medicine AwardYale Aging CenterDetailsUnited States
Teaching & Mentoring
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Mentoring
Amanda Rodriguez Diaz
Graduate student2023 - Present
Willing and Available to Mentor
- Students
- Residents
- Clinical Fellows
- Postdoctoral Researchers
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Cellular & Molecular Physiology
333 Cedar Street, B-Wing, E Level
New Haven, Connecticut 06510
United States
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