2025
Common origins of autoimmune diseases and lymphoid malignancies
Leveille E, Müschen M. Common origins of autoimmune diseases and lymphoid malignancies. Trends In Immunology 2025 PMID: 40816970, PMCID: PMC12360480, DOI: 10.1016/j.it.2025.07.010.Peer-Reviewed Original ResearchLymphoid malignanciesAutoimmune diseasesRisk of lymphoma developmentDevelopment of autoimmune diseasesT-cell lymphomaDevelopment of lymphoid malignanciesMechanism of negative selectionAutoimmune manifestationsLymphoma developmentAutoreactive lymphocytesT cellsAutoimmune disordersAdaptive immunityMalignancyGenetic lesionsLymphocyte developmentPathological lymphocytesLymphocytesDisease typeDiseaseNegative selection
2023
Genetic Knockin Approaches to Reconstructing DLBCL-Subtypes from Human Germinal Center B-Cells
Khanduja D, Robinson M, Arce D, Klemm L, Leveille E, Kothari S, Caeser R, Hodson D, Müschen M. Genetic Knockin Approaches to Reconstructing DLBCL-Subtypes from Human Germinal Center B-Cells. Blood 2023, 142: 1627. DOI: 10.1182/blood-2023-190634.Peer-Reviewed Original ResearchSecondary lymphoid organsGerminal center B cellsMYD88 L265P mutationLymphoid organsLymph nodesB cellsL265P mutationHuman germinal center B cellsDLBCL subtypesNSG miceTonsillar germinal center B cellsLymphoma developmentPreclinical testingLymphoid tissue inducer cellsTransgenic expressionPoor clinical outcomeWild-type mutationsGenetic mouse modelsExon 5GC B cellsNBSGW miceClinical outcomesLTi cellsLymphoid folliclesInducer cells
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