2025
Common origins of autoimmune diseases and lymphoid malignancies
Leveille E, Müschen M. Common origins of autoimmune diseases and lymphoid malignancies. Trends In Immunology 2025 PMID: 40816970, PMCID: PMC12360480, DOI: 10.1016/j.it.2025.07.010.Peer-Reviewed Original ResearchLymphoid malignanciesAutoimmune diseasesRisk of lymphoma developmentDevelopment of autoimmune diseasesT-cell lymphomaDevelopment of lymphoid malignanciesMechanism of negative selectionAutoimmune manifestationsLymphoma developmentAutoreactive lymphocytesT cellsAutoimmune disordersAdaptive immunityMalignancyGenetic lesionsLymphocyte developmentPathological lymphocytesLymphocytesDisease typeDiseaseNegative selection
2015
Circadian Clock Protein CRY Controls B-Cell Intrinsic Tolerance
Cao Q, Zhao X, Gery S, Chen Z, Deng R, Sun H, Lin D, Zhao Z, Said J, Li Q, Muschen M, Evans R, Koeffler H. Circadian Clock Protein CRY Controls B-Cell Intrinsic Tolerance. Blood 2015, 126: 1029. DOI: 10.1182/blood.v126.23.1029.1029.Peer-Reviewed Original ResearchB cell toleranceDKO miceB cellsRheumatoid arthritisMultiple sclerosisWT miceCell toleranceSerum anti-nuclear antibodiesHigher serum IgG concentrationsMature recirculating B cellsPeripheral B cell toleranceAnti-nuclear antibodiesPre-B cell numbersWild-type miceSerum IgG concentrationB2 B cellsRecirculating B cellsAdaptive immune systemSplenic B cellsImmune toleranceSevere autoimmunitySjögren's syndromeAutoimmune disordersMassive infiltrationComplement 3
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