2025
Common origins of autoimmune diseases and lymphoid malignancies
Leveille E, Müschen M. Common origins of autoimmune diseases and lymphoid malignancies. Trends In Immunology 2025 PMID: 40816970, PMCID: PMC12360480, DOI: 10.1016/j.it.2025.07.010.Peer-Reviewed Original ResearchLymphoid malignanciesAutoimmune diseasesRisk of lymphoma developmentDevelopment of autoimmune diseasesT-cell lymphomaDevelopment of lymphoid malignanciesMechanism of negative selectionAutoimmune manifestationsLymphoma developmentAutoreactive lymphocytesT cellsAutoimmune disordersAdaptive immunityMalignancyGenetic lesionsLymphocyte developmentPathological lymphocytesLymphocytesDisease typeDiseaseNegative selection
2022
SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies
Leveille E, Chan LN, Mirza AS, Kume K, Müschen M. SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies. Cellular Signalling 2022, 94: 110331. PMID: 35398488, DOI: 10.1016/j.cellsig.2022.110331.Peer-Reviewed Original ResearchConceptsChronic lymphocytic leukemiaB-cell malignanciesT cell receptorB cell receptorB-cell chronic lymphocytic leukemiaPathological B-cellsPoor clinical outcomeAcute lymphoblastic leukemiaExpression of SykT lymphocyte developmentClinical outcomesAggressive diseaseActivation of NFATAutoimmune diseasesLymphoblastic leukemiaT lymphocytesLymphocytic leukemiaCell lymphomaLymphoid malignanciesB cellsPI3K-pathwayOncogenic driversMalignancyNegative selectionPremalignant cells
2016
Role of the transcription factor Ikaros in development of autoimmune disease
Schjerven H, Frietze S, Hai S, Hermiston M, Kogan S, Muschen M. Role of the transcription factor Ikaros in development of autoimmune disease. The Journal Of Immunology 2016, 196: 47.14-47.14. DOI: 10.4049/jimmunol.196.supp.47.14.Peer-Reviewed Original ResearchAnti-nuclear antibodiesAutoimmune diseasesB cellsB cell developmentSerum anti-nuclear antibodiesAuto-reactive B cellsReactive B cellsEx vivo analysisSpleen B cellsEx vivo studySecond signalBCR stimulationEarly B cell developmentRecent genome-wide association studiesVivo analysisMouse modelGenetic predispositionIkaros mutant miceTranscription factor IkarosMouse strainsDiseaseVivo studiesTargeted deletionZinc finger 1Autoimmunity
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