2025
Characterizing Stroke Clots Using Single-Cell Sequencing.
Renedo D, Barak T, DeLong J, Acosta J, Sujijantarat N, Koo A, Rivier C, Clocchiatti-Tuozzo S, Huo S, Antonios J, Giles J, Falcone G, Sheth K, Hebert R, Gunel M, Sansing L, Navaratnam D, Matouk C. Characterizing Stroke Clots Using Single-Cell Sequencing. Journal Of The American Heart Association 2025, 14: ejaha2025041738t. PMID: 40878981, DOI: 10.1161/jaha.125.041738.Peer-Reviewed Original ResearchConceptsMulti-marker analysisGene expressionMulti-marker Analysis of GenoMic AnnotationCell type-specific gene expressionT cellsGenome-wide association studiesGene expression of cellsSingle-cell RNA sequencingPotential biomarkersTIMP1Genes associated with atherosclerosisHLA-DRB1*01Single-cell sequencingExpression of genesUpregulated expression of genesGene expression profilesCarotid atherosclerosisGenome annotationCD8 T cellsUpregulated expressionImmune cell compositionAssociation studiesNatural killer cellsImmune cell populationsLarge vessel occlusion stroke
2024
306 Endothelial Infiltrating Regulatory B Cells and NK T Cells Precipitate Inflammatory Cascade That Leads to Aneurysmal Rupture
Antonios J, Barak T, Gultekin B, Yalcin K, Adenu-Mensah N, Sujijantarat N, Koo A, Haynes J, Hebert R, Matouk C, Gunel M. 306 Endothelial Infiltrating Regulatory B Cells and NK T Cells Precipitate Inflammatory Cascade That Leads to Aneurysmal Rupture. Neurosurgery 2024, 70: 88-89. DOI: 10.1227/neu.0000000000002809_306.Peer-Reviewed Original ResearchRegulatory B cellsB cellsSentinel hemorrhageNK cellsInflammatory cascadeCytotoxic CD8 T cellsRecruitment of NK cellsCD8 T cellsAdjunctive immune therapyEndovascular coil embolizationCoordinated immune responseIntracranial aneurysm developmentImmune therapyRecurrent aneurysmsAneurysmal vessel wallT cellsCoil embolizationRuptured aneurysmsTime of ruptureAneurysm ruptureUnruptured aneurysmsInfiltrating populationPatient populationImmune responseAneurysm development
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