2025
126 Intracranial Aneurysm Progression and Rupture States Correlate with Dynamic Aneurysmal Immune Landscape
Antonios J, Gultekin B, Theriault B, Yalcin K, Miyagishima D, Sujijantarat N, Koo A, Haynes J, Nowicki K, Hebert R, Barak T, Matouk C, Gunel M. 126 Intracranial Aneurysm Progression and Rupture States Correlate with Dynamic Aneurysmal Immune Landscape. Neurosurgery 2025, 71: 25-25. DOI: 10.1227/neu.0000000000003360_126.Peer-Reviewed Original ResearchRuptured IAMultivariate logistic regression analysisUnruptured IACD4 T cellsImmune cell subsetsImmune cell populationsAneurysm growth rateImmune cell behaviorLogistic regression analysisImmune cell polarizationNon-invasive strategyImmune signaturesGenes related to immune responseImmune landscapeCell subsetsImmune pathophysiologyImmune profileT cellsImmunological markersAntigen presentationAneurysm progressionImmune cascadePoor morbidityPublic health challengeImmune response
2021
Spatially Resolved and Quantitative Analysis of the Immunological Landscape in Human Meningiomas
Yeung J, Yaghoobi V, Aung TN, Vesely MD, Zhang T, Gaule P, Gunel M, Rimm DL, Chen L. Spatially Resolved and Quantitative Analysis of the Immunological Landscape in Human Meningiomas. Journal Of Neuropathology & Experimental Neurology 2021, 80: 150-159. PMID: 33393633, DOI: 10.1093/jnen/nlaa152.Peer-Reviewed Original ResearchConceptsPD-L1 expressionT cell infiltrationPD-L1PD-L2Human meningiomasTumor-infiltrating immune cell populationsHigh PD-L1 expressionT-cell activation/proliferationActivation/dysfunctionLevels of CD3Immune cell subsetsT-cell phenotypeImmune cell populationsHigh-grade tumorsActivation/proliferationHigher CD3TIL infiltrationCD8 ratioImmunotherapeutic strategiesCell subsetsImmunological statusGrade tumorsImmunological landscapeTissue microarrayMacrophage phenotype
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