Posterior parasagittal meningiomas display aggressive features independent of size: a multicenter analysis
Koçyiğit S, Chavez M, Orhun Ö, O’Brien J, Inan A, Yaşar A, Dinçer A, Moliterno J, Günel M, Pamir M, Özduman K, Erşen-Danyeli A. Posterior parasagittal meningiomas display aggressive features independent of size: a multicenter analysis. Journal Of Neuro-Oncology 2025, 175: 101-110. PMID: 40569492, PMCID: PMC12367906, DOI: 10.1007/s11060-025-05103-z.Peer-Reviewed Original ResearchConceptsParasagittal meningiomaAnatomical locationKi67 indexWHO-gradeAggressive featuresTumor volume ratioChromosome 1p lossGrading criteriaResultsTumor volumeLarge meningiomasHistological subtypesAggressive biologyHistological gradeMolecular subsetsMulticenter analysisCohort BMeningioma sizeMitotic countRadiological featuresTumor behaviorRisk stratificationBrain invasionRetrospective analysisHistopathological markersIndependent cohortChromosome 1p Loss and 1q Gain for Grading of Meningioma
Landry A, Wang J, Patil V, Liu J, Gui C, Ellenbogen Y, Ajisebutu A, Yefet L, Wei Q, Singh O, Sosa J, Mansouri S, Cohen-Gadol A, Tabatabai G, Tatagiba M, Behling F, Barnholtz-Sloan J, Sloan A, Chotai S, Chambless L, Mansouri A, Makarenko S, Yip S, Ehret F, Capper D, Tsang D, Moliterno J, Gunel M, Wesseling P, Sahm F, Aldape K, Gao A, Zadeh G, Nassiri F. Chromosome 1p Loss and 1q Gain for Grading of Meningioma. JAMA Oncology 2025, 11: 644-649. PMID: 40178835, PMCID: PMC11969356, DOI: 10.1001/jamaoncol.2025.0329.Peer-Reviewed Original ResearchConceptsClassification of central nervous system tumorsChromosomal copy number alterationsProgression-free survivalChromosome 1p lossCopy number alterationsLoss of chromosome 1pGrading of meningiomasWHO gradeWorld Health OrganizationChromosome 1pWorld Health Organization grade 1 meningiomasWorld Health Organization grade 1 tumorWorld Health Organization grade 2 tumorsGain of chromosome 1qHomozygous deletion of CDKN2AAssociated with significantly worse outcomesCentral nervous system tumorsHistopathological diagnosis of meningiomaGrade 3 tumorsGrade 1 tumorsGrade 2 tumorsLoss of 1pGrade 1 meningiomasOutcomes of patientsDeletion of CDKN2A
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