Chromosome 1p Loss and 1q Gain for Grading of Meningioma
Landry A, Wang J, Patil V, Liu J, Gui C, Ellenbogen Y, Ajisebutu A, Yefet L, Wei Q, Singh O, Sosa J, Mansouri S, Cohen-Gadol A, Tabatabai G, Tatagiba M, Behling F, Barnholtz-Sloan J, Sloan A, Chotai S, Chambless L, Mansouri A, Makarenko S, Yip S, Ehret F, Capper D, Tsang D, Moliterno J, Gunel M, Wesseling P, Sahm F, Aldape K, Gao A, Zadeh G, Nassiri F. Chromosome 1p Loss and 1q Gain for Grading of Meningioma. JAMA Oncology 2025, 11: 644-649. PMID: 40178835, PMCID: PMC11969356, DOI: 10.1001/jamaoncol.2025.0329.Peer-Reviewed Original ResearchConceptsClassification of central nervous system tumorsChromosomal copy number alterationsProgression-free survivalChromosome 1p lossCopy number alterationsLoss of chromosome 1pGrading of meningiomasWHO gradeWorld Health OrganizationChromosome 1pWorld Health Organization grade 1 meningiomasWorld Health Organization grade 1 tumorWorld Health Organization grade 2 tumorsGain of chromosome 1qHomozygous deletion of CDKN2AAssociated with significantly worse outcomesCentral nervous system tumorsHistopathological diagnosis of meningiomaGrade 3 tumorsGrade 1 tumorsGrade 2 tumorsLoss of 1pGrade 1 meningiomasOutcomes of patientsDeletion of CDKN2A
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