2025
Posterior parasagittal meningiomas display aggressive features independent of size: a multicenter analysis
Koçyiğit S, Chavez M, Orhun Ö, O’Brien J, Inan A, Yaşar A, Dinçer A, Moliterno J, Günel M, Pamir M, Özduman K, Erşen-Danyeli A. Posterior parasagittal meningiomas display aggressive features independent of size: a multicenter analysis. Journal Of Neuro-Oncology 2025, 175: 101-110. PMID: 40569492, PMCID: PMC12367906, DOI: 10.1007/s11060-025-05103-z.Peer-Reviewed Original ResearchConceptsParasagittal meningiomaAnatomical locationKi67 indexWHO-gradeAggressive featuresTumor volume ratioChromosome 1p lossGrading criteriaResultsTumor volumeLarge meningiomasHistological subtypesAggressive biologyHistological gradeMolecular subsetsMulticenter analysisCohort BMeningioma sizeMitotic countRadiological featuresTumor behaviorRisk stratificationBrain invasionRetrospective analysisHistopathological markersIndependent cohort
2017
Use of telomerase promoter mutations to mark specific molecular subsets with reciprocal clinical behavior in IDH mutant and IDH wild-type diffuse gliomas.
Akyerli CB, Yüksel Ş, Can Ö, Erson-Omay EZ, Oktay Y, Coşgun E, Ülgen E, Erdemgil Y, Sav A, von Deimling A, Günel M, Yakıcıer MC, Pamir MN, Özduman K. Use of telomerase promoter mutations to mark specific molecular subsets with reciprocal clinical behavior in IDH mutant and IDH wild-type diffuse gliomas. Journal Of Neurosurgery 2017, 128: 1102-1114. PMID: 28621624, DOI: 10.3171/2016.11.jns16973.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overBrain NeoplasmsCohort StudiesDNA Mutational AnalysisFemaleGenetic MarkersGliomaHumansIsocitrate DehydrogenaseKaplan-Meier EstimateKi-67 AntigenMaleMiddle AgedMutationPromoter Regions, GeneticSurvival AnalysisTelomeraseTreatment OutcomeYoung AdultConceptsMolecular subsetsIDH-wt gliomasIDH wild-type diffuse gliomasDiffuse gliomasIDH-mut gliomasClinical behaviorTERTp-mutHigh Ki-67 labeling indexKi-67 labeling indexDouble-negative subsetObjective Recent studiesClinical tumor behaviorDifferent tumor biologySpecific molecular subsetsTERT promoter mutationsEpidermal growth factor receptorTensin homolog (PTEN) mutationsTelomerase promoter mutationsCumulative followGrowth factor receptorSurgical cohortMalignant degenerationClinical parametersHistopathological diagnosisCombined status
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