2025
Characterizing Stroke Clots Using Single-Cell Sequencing.
Renedo D, Barak T, DeLong J, Acosta J, Sujijantarat N, Koo A, Rivier C, Clocchiatti-Tuozzo S, Huo S, Antonios J, Giles J, Falcone G, Sheth K, Hebert R, Gunel M, Sansing L, Navaratnam D, Matouk C. Characterizing Stroke Clots Using Single-Cell Sequencing. Journal Of The American Heart Association 2025, 14: ejaha2025041738t. PMID: 40878981, DOI: 10.1161/jaha.125.041738.Peer-Reviewed Original ResearchConceptsMulti-marker analysisGene expressionMulti-marker Analysis of GenoMic AnnotationCell type-specific gene expressionT cellsGenome-wide association studiesGene expression of cellsSingle-cell RNA sequencingPotential biomarkersTIMP1Genes associated with atherosclerosisHLA-DRB1*01Single-cell sequencingExpression of genesUpregulated expression of genesGene expression profilesCarotid atherosclerosisGenome annotationCD8 T cellsUpregulated expressionImmune cell compositionAssociation studiesNatural killer cellsImmune cell populationsLarge vessel occlusion stroke
2000
Intraoperative endovascular treatment as an adjunct to microsurgical clipping of paraclinoid aneurysms.
Ng PY, Huddle D, Gunel M, Awad IA. Intraoperative endovascular treatment as an adjunct to microsurgical clipping of paraclinoid aneurysms. Journal Of Neurosurgery 2000, 93: 554-60. PMID: 11014532, DOI: 10.3171/jns.2000.93.4.0554.Peer-Reviewed Original ResearchConceptsInternal carotid arterySuction decompressionIntraoperative angiographyProximal controlMicrosurgical clippingEndovascular proceduresParaclinoid aneurysmsIntraoperative digital subtraction angiographyOptic canal decompressionFemoral artery catheterizationLarge paraclinoid aneurysmComplete aneurysm obliterationResidual aneurysm fillingDigital subtraction angiographyMajor infarctCanal decompressionArtery catheterizationBalloon occlusionEndovascular treatmentEndovascular methodsMicrosurgical treatmentParaclinoid segmentSubarachnoid hemorrhageVisual deteriorationTemporary clips
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