Scott Miller

Irenee du Pont Professor of Chemistry; Professor; Department Chair

Contact Information

Scott Miller

Biography

Dr. Miller's laboratory is focused on the creation of new catalysts for complex molecule synthesis and derivatization. Historically, the Miller Lab has endeavored to develop peptide-based catalysts for enantioselective reactions. They have also attempted to bring the principles of asymmetric catalysis into areas of other types of selective synthesis (e.g., regioselectivity, site-selectivity and chemoselectivity), with a particular focus on natural product diversification.  They focus on molecular functionality that is ubiquitous in complex natural products, thus allowing these naturally occurring materials to be used as scaffolds for new bioactive entity synthesis. In orthogonal projects, the Miller Lab has developed catalysts for many enantioselective reactions, with a focus on unusual and biochemically relevant aspects of stereochemistry.

The Miller Lab's focus for catalyst development has been on peptide-based catalysts. The catalysts they generate have therefore allowed for a consideration of mechanistic analogies to enzymes. This strategy has also enabled optimization of the catalysts with the development of a range of combinatorial methods for catalyst screening.

Activities

  • Synthesis and Study of Organocatalysts Tethered to Dendronized Polymer Support
    Israel (2009-2013)
    We are trying to develop a new class of catalysts for synthetic chemistry that are based on simple organic molecules that are immobilized on dendritic polymer supports. These studies have fundamental value in that they may unveil new effects that are specific to a polymeric scaffold. Catalysts may also offer improved efficiency and recyclability which has advantages for reducing environmental impacts. URL: http://onlinelibrary.wiley.com/doi/10.1002/chem.201102474/abstract
  • Synthesis and Study of Organocatalysts Tethered to Dendronized Polymer Support
    United States (2009-2013)
    We are trying to develop a new class of catalysts for synthetic chemistry that are based on simple organic molecules that are immobilized on dendritic polymer supports. These studies have fundamental value in that they may unveil new effects that are specific to a polymeric scaffold. Catalysts may also offer improved efficiency and recyclability which has advantages for reducing environmental impacts. URL: http://onlinelibrary.wiley.com/doi/10.1002/chem.201102474/abstract

Departments & Organizations