Adjunct Faculty
Adjunct Faculty are scientists or others who are employed outside of the school but have a specific, mutually beneficial role to Yale School of Medicine department programs.
Adjunct rank detailsToma Tebaldi, PhD
Assistant Professor AdjunctDownloadHi-Res Photo
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Titles
Assistant Professor Adjunct
Biography
My research aims at understanding the RNA molecular mechanisms underlying dysregulation in human diseases, by combining experimental and computational approaches and with focus on alternative splicing events, binding of non-coding RNAs and mutant RNA binding proteins, RNA modifications (the epitranscriptome), translation dynamics and single cell expression data.
https://www.researchgate.net/profile/Toma_Tebaldi
https://orcid.org/0000-0002-0625-1631
Last Updated on February 11, 2025.
Appointments
Medical Oncology and Hematology
Assistant Professor AdjunctPrimary
Other Departments & Organizations
- Genomics, Genetics, and Epigenetics
- Hematology
- Internal Medicine
- Medical Oncology and Hematology
- Yale Cancer Center
- Yale-BI Biomedical Data Science Fellowship
Education & Training
- Visiting Professor
- University of Trento (2020)
- Visiting Professor
- University of Trento (2019)
- Postdoctoral fellowship
- University of Trento (2017)
- EMBO Short Fellowship
- University of Edinburgh (2015)
- International Internship
- University of Edinburgh (2013)
- Postdoctoral fellowship
- University of Trento (2013)
- Postdoctoral fellowship
- University of Trento (2012)
- PhD
- University of Trento, Information and Communication Technology (2010)
- International internship
- Harvard Medical School (2009)
- International internship
- University of Sheffield (2009)
- MSc
- University of Milano Bicocca, Biotechnologies - Bioinformatics (2006)
- BSc
- University of Milano Bicocca, Biotechnologies (2003)
Research
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Overview
RNA biology
Medical Research Interests
Computational Biology; Hematologic Neoplasms
ORCID
0000-0002-0625-1631
Research at a Glance
Yale Co-Authors
Frequent collaborators of Toma Tebaldi's published research.
Publications Timeline
A big-picture view of Toma Tebaldi's research output by year.
Research Interests
Research topics Toma Tebaldi is interested in exploring.
Stephanie Halene, MD, Dr Med
Giulia Biancon, PhD
Diane Krause, MD, PhD
Emanuela Bruscia, PhD
Jennifer VanOudenhove, PhD
Marie Egan, MD
29Publications
292Citations
Computational Biology
Publications
2025
RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation
Mayday M, Biancon G, Wei M, Ramirez C, Moratti I, Pintado-Urbanc A, Espinosa J, Chen M, Wang L, Simon M, Ofir-Rosenfeld Y, Rausch O, Tebaldi T, Halene S, Krause D. RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation. Blood 2025, 146: 1096-1109. PMID: 40435410, DOI: 10.1182/blood.2024027712.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRNA fateM6A modificationFusion proteinWnt pathway activationFrizzled genesFunctions of RBM15Dysregulation of m6A modificationRBM15-MKL1Pathway activationMulti-omics approachInduced apoptosis in vitroWnt Signaling PathwayApoptosis in vitroM6A depositionRNA bindingSpecific RNAGrowth in vitroM6A methylationMRNA targetsSignaling pathwayWnt pathwayWnt signalingM6A modifiersM6A-dependent mechanismRNACell Marker Accordion: interpretable single-cell and spatial omics annotation in health and disease
Busarello E, Biancon G, Cimignolo I, Lauria F, Ibnat Z, Ramirez C, Tomè G, Ciuffreda M, Bucciarelli G, Pilli A, Marino S, Bontempi V, Ress F, Aass K, VanOudenhove J, Tiberi L, Mione M, Standal T, Macchi P, Viero G, Halene S, Tebaldi T. Cell Marker Accordion: interpretable single-cell and spatial omics annotation in health and disease. Nature Communications 2025, 16: 5399. PMID: 40623970, PMCID: PMC12234662, DOI: 10.1038/s41467-025-60900-4.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSingle-cellBiological interpretationCell typesSingle-cell technologiesIdentification of cell typesMultiple single-cellPhysiological cell typesSingle-cell populationsCellular heterogeneityDisease contextsInconsistent annotationsMurine tissuesWeight markersAnnotationCellsSpatial populationAnnotation accuracyPathological processesAvailable databasesMarkersPotential biomarkersAutomatic annotationPhysiologyUnique opportunityDiseaseComputational limitations and future needs to unravel the full potential of 2’-O-methylation and C/D box snoRNAs
Ramirez C, Perenthaler E, Lauria F, Tebaldi T, Viero G. Computational limitations and future needs to unravel the full potential of 2’-O-methylation and C/D box snoRNAs. RNA Biology 2025, 22: 1-11. PMID: 40377202, PMCID: PMC12218551, DOI: 10.1080/15476286.2025.2506712.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsThe efficacy of METTL3 inhibition in pre-clinical models of MDS and AML.
Kenworthy C, Wei M, VanOudenhove J, Busarello E, Ramirez Amarilla C, Paul S, Cruz J, Baassiri A, Maul-Newby H, Biancon G, Tebaldi T, Halene S. The efficacy of METTL3 inhibition in pre-clinical models of MDS and AML. Journal Of Clinical Oncology 2025, 43 DOI: 10.1200/jco.2025.43.16_suppl.e18584.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaMyelodysplastic syndromeInnate immune responseImmune signaturesTransplantation modelModel of myelodysplastic syndromeMurine models of leukemiaPreclinical anti-tumour efficacyImmune responseInnate immune cell subsetsSolid tumor clinical trialsSplicing factorsCompetitive transplant modelImmune checkpoint inhibitionMouse solid tumor modelsDouble-stranded RNAMyelodysplastic syndrome patientsInnate immune signaturesAnti-tumor efficacyImmune cell subsetsMyelodysplastic syndromes pathogenesisDriver genesSolid tumor modelsPre-clinical modelsModels of leukemiaImpact of memory T cells on SARS-CoV-2 vaccine response in hematopoietic stem cell transplant
VanOudenhove J, Liu Y, Nelakanti R, Kim D, Busarello E, Ovalle N, Qi Z, Mamillapalli P, Siddon A, Bai Z, Axtmayer A, Corso C, Kothari S, Foss F, Isufi I, Tebaldi T, Gowda L, Fan R, Seropian S, Halene S. Impact of memory T cells on SARS-CoV-2 vaccine response in hematopoietic stem cell transplant. PLOS ONE 2025, 20: e0320744. PMID: 40294012, PMCID: PMC12036906, DOI: 10.1371/journal.pone.0320744.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsHematopoietic stem cell transplantationMemory T cellsStem cell transplantationCell transplantationT cellsSARS-CoV-2Hematopoietic stem cell transplant recipientsAntigen-specific T-cell activationSARS-CoV-2 mRNA vaccinesSARS-CoV-2 vaccine responsesSevere diseaseAnti-spike IgGT cell activationAdaptive immune responsesRobust antibody responsesPost-vaccination responseSARS-CoV-2 infectionMRNA vaccine seriesSingle-cell RNAMyeloablative chemotherapyCellular responsesImmune profileVaccine responseCOVID-19 infectionMRNA vaccinesAn in vivo screen identifies NAT10 as a master regulator of brain metastasis
Chen J, Xu P, Cai W, Chen H, Wingrove E, Shi X, Li W, Biancon G, Zhang M, Balabaki A, Krop E, Asare E, Zhang Y, Yin M, Tebaldi T, Meier J, Westbrook T, Halene S, Liu Y, Shen H, Nguyen D, Yan Q. An in vivo screen identifies NAT10 as a master regulator of brain metastasis. Science Advances 2025, 11: eads6021. PMID: 40138393, PMCID: PMC11939035, DOI: 10.1126/sciadv.ads6021.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPhosphoserine aminotransferase 1Metastasis in vivoIn vivo screeningRNA helicase domainRegulator of brain metastasisMetastatic breast cancer cellsBrain metastasis in vivoBrain metastasesRNA helicaseCell growth in vitroBreast cancer cellsCancer cell proliferationSerine biosynthesisEpigenetic regulationGrowth in vitroNAT10Migration in vitroCancer cellsTumor growthCell proliferationPrimary tumor growthDrivers of brain metastasesRNACancer metastasisCancer-related deathsDissecting the stress granule RNA world: dynamics, strategies and data
Biancon G, Busarello E, Cheng M, Halene S, Tebaldi T. Dissecting the stress granule RNA world: dynamics, strategies and data. RNA 2025, 31: rna.080409.125. PMID: 40086831, PMCID: PMC12084887, DOI: 10.1261/rna.080409.125.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsStress granulesRNA worldRegulation of gene expressionRNA-binding proteinsCytoplasmic ribonucleoprotein granulesRibonucleoprotein granulesTranscriptome dataRNA componentSG dynamicsCell signalingSG compositionSG componentsGene expressionCellular adaptationHuman diseasesStress conditionsExperimental strategiesRNAProteinComprehensive understandingMRNAGranulesRegulation
2024
Ezrin drives adaptation of monocytes to the inflamed lung microenvironment
Gudneppanavar R, Di Pietro C, H Öz H, Zhang P, Cheng E, Huang P, Tebaldi T, Biancon G, Halene S, Hoppe A, Kim C, Gonzalez A, Krause D, Egan M, Gupta N, Murray T, Bruscia E. Ezrin drives adaptation of monocytes to the inflamed lung microenvironment. Cell Death & Disease 2024, 15: 864. PMID: 39613751, PMCID: PMC11607083, DOI: 10.1038/s41419-024-07255-8.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsActivation of focal adhesion kinaseExtracellular matrixActin-binding proteinsFocal adhesion kinaseLung extracellular matrixKnock-out mouse modelProtein Kinase SignalingCortical cytoskeletonLoss of ezrinKinase signalingPlasma membraneCell migrationSignaling pathwayEzrinResponse to lipopolysaccharideTissue-resident macrophagesMouse modelLipopolysaccharideCytoskeletonEzrin expressionLung microenvironmentKinaseMonocyte recruitmentProteinAktComparative proteomic analysis of human vitreous in rhegmatogenous retinal detachment and diabetic retinopathy reveals a common pathway and potential therapeutic target
Brighenti T, Neri G, Mazzola M, Tomé G, Scalfati M, Peroni D, Belli R, Zampedri E, Tebaldi T, Borello U, Romanelli F, Casarosa S. Comparative proteomic analysis of human vitreous in rhegmatogenous retinal detachment and diabetic retinopathy reveals a common pathway and potential therapeutic target. Clinical Proteomics 2024, 21: 63. PMID: 39609746, PMCID: PMC11603643, DOI: 10.1186/s12014-024-09515-3.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRhegmatogenous retinal detachmentDiabetic retinopathyNon-steroidal anti-inflammatory drugsRetinal detachmentVitreoretinal diseasesPotential therapeutic targetProliferative vitreoretinopathyOphthalmic non-steroidal anti-inflammatory drugTherapeutic targetAnalysis of vitreous samplesProteomic signatureGlucose metabolismNitric oxide levelsAnti-inflammatory drugsElevated nitric oxide levelsMacular puckerPhotoreceptor deathImprove quality of lifeAldo-keto reductase family 1 member B1Vitreous samplesRetinal cellsVascular proliferationFibrous proliferationReduce complicationsHuman vitreousUnraveling the Drivers of the Stress Granule Signature in Splicing Factor-Mutant Myeloid Malignancies
Biancon G, Busarello E, Cheng M, Sidoli S, VanOudenhove J, Bucciarelli G, Tebaldi T, Halene S. Unraveling the Drivers of the Stress Granule Signature in Splicing Factor-Mutant Myeloid Malignancies. Blood 2024, 144: 4117. DOI: 10.1182/blood-2024-211265.Peer-Reviewed Original ResearchCitationsConceptsRNA-binding proteinsStress granulesRNA-seqArsenite stressSF mutationsAcute myeloid leukemiaSplicing factorsSG proteinsStress responseClonal advantageSG coresMulti-OmicsDeregulated genesMyelodysplastic syndromeEnhances SG formationU2AF1 S34F mutationSingle-cell RNA-seqWT cellsMegakaryocyte-erythroid progenitorsRegulation of translationTranslation initiation factorsImprove cell fitnessRNA-seq analysisPost-translational modificationsU2AF1 mutations
Academic Achievements & Community Involvement
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Activities
activity Frontiers in Genetics - Computational Biology
2021 - PresentJournal ServiceAssociate Editoractivity PRIN 2020 MIUR
2021 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity Yale Center for Biomedical Data Science
2018 - PresentProfessional OrganizationsMemberactivity Yale Cancer Center
2020 - PresentProfessional OrganizationsMemberactivity Italian Society of Yale Students and Affiliates
2017 - PresentProfessional OrganizationsBoard Member
Honors
honor Italian National Scientific Qualification as Associate Professor in Applied Biology
05/15/2021International AwardMinistry of Education, University and Research (Italy)DetailsItalyhonor Italian National Scientific Qualification as Associate Professor in Molecular Biology
01/14/2020International AwardMinistry of Education, University and Research (Italy)DetailsItalyhonor Yale YCCEH Pilot and Feasibility Program Award
11/13/2018Yale School of Medicine AwardYale YCCEHDetailsUnited Stateshonor RNA Society Travel Award: RNA2016, Kyoto
06/09/2016National AwardRNA SocietyDetailsUnited Stateshonor EMBO Travel Grant Award: Protein synthesis and translational control
07/21/2015International AwardEuropean Molecular Biology OrganizationDetailsGermany
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