2022
Longitudinal single-cell analysis of a patient receiving adoptive cell therapy reveals potential mechanisms of treatment failure
Qu R, Kluger Y, Yang J, Zhao J, Hafler D, Krause D, Bersenev A, Bosenberg M, Hurwitz M, Lucca L, Kluger H. Longitudinal single-cell analysis of a patient receiving adoptive cell therapy reveals potential mechanisms of treatment failure. Molecular Cancer 2022, 21: 219. PMID: 36514045, PMCID: PMC9749221, DOI: 10.1186/s12943-022-01688-5.Peer-Reviewed Original ResearchConceptsAdoptive cell therapySingle-cell analysisDepth single-cell analysisSingle-cell RNAACT productsDisease progressionT-cell receptor sequencingCell therapyFamily genesFeatures of exhaustionMultiple tumor typesCell expansionGenesNew clonotypesTIL preparationsClonal cell expansionCytokine therapyTreatment failureSerial bloodClonesEffector functionsSerial samplesTumor typesCellular therapyTherapy
2004
Lineage specificity of gene expression patterns
Kluger Y, Tuck DP, Chang JT, Nakayama Y, Poddar R, Kohya N, Lian Z, Nasr A, Halaban HR, Krause DS, Zhang X, Newburger PE, Weissman SM. Lineage specificity of gene expression patterns. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 6508-6513. PMID: 15096607, PMCID: PMC404075, DOI: 10.1073/pnas.0401136101.Peer-Reviewed Original ResearchConceptsGene expression patternsExpression patternsExpression dataGene Ontology databaseTree of relationshipsStem cellsBroad functional categoriesHematopoietic cell populationsMRNA expression dataHematopoietic programBioCarta databasesGenome databaseLineage choiceHematopoietic stem cellsKyoto EncyclopediaDifferent lineagesFunctional categoriesLineage developmentCell lineagesGene expressionLineage specificityOligonucleotide microarraysFunctional pathwaysLineage discriminationOntology database