David Adam Spiegel

Professor of Chemistry

Research Organizations

Molecular Virology: Virology Laboratories

Yale Cancer Center: Developmental Therapeutics

Global Health Studies

Office of Cooperative Research

Research Summary

The Spiegel Laboratory works in the area of “Synthetic Immunology,” which integrates synthetic chemistry, immunology, and cell biology toward the development of systems capable of controlling and/or creating human immunity. In particular, the lab has developed a class of antibody-recruiting small molecules (ARMs) that are capable of enhancing recognition of diverse pathogens by the human immune system. We have successfully employed this approach in targeting both HIV and prostate cancer, and are currently expanding its scope toward other diseases as well. Other areas of interest include re-engineering bacteria to perform complex immunological tasks, and investigations into advanced glycation end-products (AGEs), a poorly understood class of immunomodulatory post-translational modifications of proteins.

Selected Publications

Full List of PubMed Publications

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