Karl L. Insogna, MD

Ensign Professor of Medicine (Endocrinology); Director; Ensign Professor of Medicine without Term; Associate Director, Yale Center for X-Linked Hypophosphatemia

Departments & Organizations

Internal Medicine: Diabetes Research Center | Endocrinology: Bone Center (Endocrinology); Fellowship Training; Insogna Lab | Liver Center | Yale Core Center for Musculoskeletal Disorders

Center for X-Linked Hypophosphatemia, Yale

Discovery to Cure Internship

WHRY Pilot Project Program Investigators

Yale Cancer Center: Signal Transduction

Yale Medicine

Office of Cooperative Research


Dr. Karl Insogna is a tenured Professor at Yale and an internationally recognized expert in the field of metabolic bone disease. He has published widely on the topic in the field's leading scientific journals, is quoted often in the lay press, and has frequently appeared on radio and television. He is a Fellow of the American Association for the Advancement of Science, and was a member of the National Institutes of Health Consensus Conference, which established new recommendations for the optimal level of calcium intake for all Americans - now adopted nationwide. He is a leading researcher in the causes of bone loss in such diseases as osteoporosis and primary hyperparathyroidism, and is currently conducting studies in, among other areas, the role of diet in the development of osteoporosis.

Education & Training

MD University of Connecticut (1976)
BA University of Connecticut (Honors Program), Biology (1972)
Research Associate Veterans Administration Medical Center
Postdoctoral Fellow Yale University School of Medicine
Chief Resident University of Rochester
Residency University of Rochester
Board Certification AB of Internal Medicine, Internal Medicine (1979)
Board Certification AB of Internal Medicine, Endocrinology, Diabetes & Metabolism (1983)

Honors & Recognition

  • Champions of Hope, “RARE Champion of Hope –Medical Caregiver”The Global Genes Project (2014)

  • Elected to the Board of Trustees, National Osteoporosis Foundation (2011)

  • Elected to the Connecticut Academy of Science and Engineering (2010)

  • Elected to the Interurban Club (2002)

  • Elected to American Association for the Advancement of Science Fellow (1997)

  • Elected to American Society for Clinical Investigation (1994)

Professional Service

  • Skeletal Biology Development and Disease Study Section (SBDD) (2015 - Present) NIH Reviewer

  • National Osteoporosis Foundation (NOF) (2012 - Present) Chair for the Audit Committee of the NOF

  • Skeletal Biology Development and Disease Study Section (SBDD) (2011 - 2012) NIH Reviewer

  • External Advisory Committee for Dr. Carlos Isales’s PO1 at the Georgia Health Sciences University (2011 - Present) Committee Member

  • New Haven County Medical Association (2011 - Present) Member of the Board of Governors

  • Raymond P. Wong Fellowship Committee (2008 - Present) The Raymond P Wong Award honors the legacy of Raymond Wong, MD, who was one of the most dedicated primary care physicians in our community and a prominent contributor to the education of our students and house staff. Originally established by Yale New Haven Hospital, the Yale Medical Board and the New Haven County Medical Association in 2009, the Fellowship is now supported by Yale New Haven Hospital, the Yale Medical Board and the Department of Internal Medicine. The Wong Award is given to a graduating member or recent graduate of the Internal Medicine, Primary Care, or Medicine/Pediatric Residencies at Yale New Haven Hospital who accepts a practice position in an urban care setting in New Haven, preferably, but not exclusively, at the Cornell Scott Hill Health Center, for at least 3 years.

  • NIH/NIAMS Safety Officer (2008) Served as safety officer for the following trial: “Continuous vs Cyclic Treatment with teriparatide and alendronate combined or Teriparatide alone in women with osteoporosis” (PI: Robert Lindsay, MD, Helen Hayes Hospital)

  • Editorial Board, Aging (2000 - Present) Editor

  • OBM-2 Study Section (1999 - 2003) Permanent Member

  • American Society for Bone and Mineral Research (1998 - 2001) Member of the Advocacy Committee

  • Women's Health Research at Yale (1997 - Present) Member of the Scientific Review Committee

  • NIH Special Study Section for RFA on Osteoporosis (1997) Study Section Member

  • Editorial Board, Bone (1994 - 2001) Editor

  • Editorial Board, Endocrinology (1993 - 1994) Editor

  • NIH Special Study Section for RFA on Osteoporosis (1992) Study Section Member

  • Yale Brown Coxe BSRG Funds and Fellowship Committee (1991 - 1994) Committee Member

  • Veterans Administration Career Development Study Section (1986) Ad Hoc Member

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Contact Info

Karl L. Insogna, MD
Patient Care Locations
Yale Endocrinology & MetabolismDana Clinic Building
789 Howard Avenue, Ste 2nd Floor

New Haven, CT 06519
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Yale Bone CenterYale New Haven Hospital
20 York Street, Ste EP- 10th Floor

New Haven, CT 06510
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Mailing Address
EndocrinologyPO Box 208020
333 Cedar Street

New Haven, CT 06520-8020

Insogna Lab